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    Tp53bp1 tumor protein p53 binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296099, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tp53bp1provided by RGD
    Official Full Name
    tumor protein p53 binding protein 1provided by RGD
    Primary source
    RGD:1308039
    See related
    Ensembl:ENSRNOG00000013837 AllianceGenome:RGD:1308039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trp53bp1
    Summary
    Predicted to enable several functions, including DNA binding activity; histone binding activity; and p53 binding activity. Involved in cellular response to X-ray. Located in nucleus. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 150.1), Adrenal (RPKM 87.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tp53bp1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128620320..128724716, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108166574..108270229, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113160030..113259701, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene adenosine deaminase-like Neighboring gene zinc finger and SCAN domain containing 29, pseudogene 1 Neighboring gene tubulin gamma complex component 4 Neighboring gene microtubule-associated protein 1A Neighboring gene diphosphoinositol pentakisphosphate kinase 1 Neighboring gene creatine kinase, mitochondrial 1 Neighboring gene stereocilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of replicative senescence by rapamycin in rodent embryonic cells. Pospelova TV, et al. Cell Cycle, 2012 Jun 15. PMID 22672902
    2. Effect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cycle. Casafont I, et al. Acta Neuropathol, 2011 Oct. PMID 21915754
    3. Proapoptotic and antitumor activities of adenovirus-mediated p202 gene transfer. Ding Y, et al. Clin Cancer Res, 2002 Oct. PMID 12374701
    4. p202, an interferon-inducible protein, mediates multiple antitumor activities in human pancreatic cancer xenograft models. Wen Y, et al. Cancer Res, 2001 Oct 1. PMID 11585747
    5. Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. Hartlerode AJ, et al. PLoS One, 2012. PMID 23209566, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-modified histone reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to X-ray IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via classical nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of isotype switching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA repair complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in replication fork ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TP53-binding protein 1
    Names
    transformation related protein 53 binding protein 1
    tumor suppressor p53-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371259.1 → NP_001358188.1  TP53-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      CK840114, JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AB98, A0A8I6AKV2
      Related
      ENSRNOP00000093681.1, ENSRNOT00000107143.1
      Conserved Domains (4) summary
      TIGR03835
      Location:705 → 992
      termin_org_DnaJ; terminal organelle assembly protein TopJ
      cd17745
      Location:1688 → 1799
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:1444 → 1564
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:1827 → 1930
      BRCT_3; BRCA1 C Terminus (BRCT) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      128620320..128724716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592215.3 → XP_017447704.1  TP53-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AB98, F1M842
      Related
      ENSRNOP00000019025.7
      Conserved Domains (2) summary
      smart00292
      Location:1866 → 1951
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:1484 → 1604
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor

    2. XM_063283318.1 → XP_063139388.1  TP53-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      F1M842

    3. XM_006234865.5 → XP_006234927.1  TP53-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006234927.1

      UniProtKB/TrEMBL
      A0A8I6AB98, F1M842
      Conserved Domains (2) summary
      smart00292
      Location:1866 → 1951
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:1484 → 1604
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor

    4. XM_063283319.1 → XP_063139389.1  TP53-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKV2

    5. XM_063283321.1 → XP_063139391.1  TP53-binding protein 1 isoform X4

    6. XM_063283320.1 → XP_063139390.1  TP53-binding protein 1 isoform X3

    7. XM_017592214.3 → XP_017447703.1  TP53-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AB98, F1M842
      Related
      ENSRNOP00000090164.1
      Conserved Domains (2) summary
      smart00292
      Location:1866 → 1951
      BRCT; breast cancer carboxy-terminal domain
      pfam09038
      Location:1484 → 1604
      53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor

    8. XM_039104554.2 → XP_038960482.1  TP53-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A6HPN0
      Conserved Domains (3) summary
      cd17745
      Location:774 → 885
      BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
      pfam09038
      Location:530 → 650
      53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor
      pfam18428
      Location:913 → 1016
      BRCT_3; BRCA1 C Terminus (BRCT) domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106501.1: Suppressed sequence

      Description
      NM_001106501.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: TP53BP1 (GeneID:7158).
    Nucleotide Protein Strain
    Heading Accession and Version

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