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    NEK2 NIMA related kinase 2 [ Homo sapiens (human) ]

    Gene ID: 4751, updated on 9-Jul-2017
    Official Symbol
    NEK2provided by HGNC
    Official Full Name
    NIMA related kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:7745
    See related
    Ensembl:ENSG00000117650 MIM:604043; Vega:OTTHUMG00000037121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NLK1; RP67; NEK2A; HsPK21; PPP1R111
    Summary
    This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]
    Orthologs
    Location:
    1q32.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (211658256..211675630, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211831598..211848972, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372903 Neighboring gene long intergenic non-protein coding RNA 1693 Neighboring gene farnesyl diphosphate synthase pseudogene 8 Neighboring gene uncharacterized LOC91548 Neighboring gene uncharacterized LOC105372904

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with NEK2 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    blastocyst development IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome separation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary basal body-plasma membrane docking TAS
    Traceable Author Statement
    more info
     
    meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic spindle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of centriole-centriole cohesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic centrosome separation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of mitotic nuclear division TAS
    Traceable Author Statement
    more info
    PubMed 
    spindle assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    condensed nuclear chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    midbody IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    protein complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    serine/threonine-protein kinase Nek2
    Names
    NIMA (never in mitosis gene a)-related kinase 2
    nimA-like protein kinase 1
    nimA-related protein kinase 2
    protein phosphatase 1, regulatory subunit 111
    NP_001191111.1
    NP_001191112.1
    NP_002488.1
    XP_005273204.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029112.1 RefSeqGene

      Range
      5001..22375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204182.1NP_001191111.1  serine/threonine-protein kinase Nek2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK225522, BT019729, DC407297
      Consensus CDS
      CCDS73024.1
      UniProtKB/Swiss-Prot
      P51955
      UniProtKB/TrEMBL
      F6U4U2
      Related
      ENSP00000440237.2, ENST00000540251.5
      Conserved Domains (2) summary
      smart00220
      Location:8271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:7271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2
    2. NM_001204183.1NP_001191112.1  serine/threonine-protein kinase Nek2 isoform 2

      See identical proteins and their annotated locations for NP_001191112.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (2, also known as NEK2B) with a distinct C-terminus compared to isoform 1. Isoforms 1 and 2 have been reported to exhibit distinct pattern of expression during mitosis (PMID:11742531).
      Source sequence(s)
      AY045701, BT019729, BU517064, DC407297
      Consensus CDS
      CCDS55682.1
      UniProtKB/Swiss-Prot
      P51955
      Related
      ENSP00000355965.3, OTTHUMP00000035217, ENST00000366998.4, OTTHUMT00000090155
      Conserved Domains (2) summary
      smart00220
      Location:8271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:7271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2
    3. NM_002497.3NP_002488.1  serine/threonine-protein kinase Nek2 isoform 1

      See identical proteins and their annotated locations for NP_002488.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longest isoform (1, also known as NEK2A). The C-terminus (aa 399-445) of this isoform was shown to be responsible for its nucleolar localization (PMID:15161910). Isoforms 1 and 2 (which differ at the C-terminus) have also been reported to exhibit distinct pattern of expression during mitosis (PMID:11742531).
      Source sequence(s)
      AK223353, BC043502, BT019729, DC407297
      Consensus CDS
      CCDS1500.1
      UniProtKB/Swiss-Prot
      P51955
      Related
      ENSP00000355966.4, OTTHUMP00000035216, ENST00000366999.8, OTTHUMT00000090154
      Conserved Domains (2) summary
      smart00220
      Location:8271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:7271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      211658256..211675630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273147.1XP_005273204.1  serine/threonine-protein kinase Nek2 isoform X1

      UniProtKB/Swiss-Prot
      P51955
      Conserved Domains (2) summary
      smart00220
      Location:8271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08217
      Location:7271
      STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      213104002..213121393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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