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    Gulp1 GULP PTB domain containing engulfment adaptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314543, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Gulp1provided by RGD
    Official Full Name
    GULP PTB domain containing engulfment adaptor 1provided by RGD
    Primary source
    RGD:1306380
    See related
    Ensembl:ENSRNOG00000003242 AllianceGenome:RGD:1306380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CED-6
    Summary
    Predicted to be involved in apoptotic process and lipid transport. Predicted to act upstream of or within phagocytosis, engulfment. Predicted to be located in cytoplasm. Orthologous to human GULP1 (GULP PTB domain containing engulfment adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 92.7), Lung (RPKM 85.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (54114823..54391058)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (46622699..46899005)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (51263484..51538066)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 21C-like 1 Neighboring gene cell division cycle associated 3 like 1 Neighboring gene U6 spliceosomal RNA Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 13 Neighboring gene adenosylhomocysteinase, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A rat homologue of CED-6 is expressed in neurons and interacts with clathrin. Martins-Silva C, et al. Brain Res, 2006 Nov 13. PMID 17007823
    2. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). Su HP, et al. J Biol Chem, 2002 Apr 5. PMID 11729193
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The present findings suggest that CED-6 may have a role in endocytic trafficking or signaling in neurons.
      Title: A rat homologue of CED-6 is expressed in neurons and interacts with clathrin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PTB domain-containing engulfment adapter protein 1
    Names
    GULP, engulfment adaptor PTB domain containing 1
    PTB domain adapter protein CED-6
    cell death protein 6 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013171.2 → NP_001013189.1  PTB domain-containing engulfment adapter protein 1

      See identical proteins and their annotated locations for NP_001013189.1

      Status: VALIDATED

      Source sequence(s)
      BC087053, BM390519, CB738009
      UniProtKB/Swiss-Prot
      Q0PYK2, Q5PQS4
      UniProtKB/TrEMBL
      A0A0G2K2Q5, A6INS9
      Related
      ENSRNOP00000072334.2, ENSRNOT00000085908.2
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150 → 191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      54114823..54391058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083451.2 → XP_038939379.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2Q5, A0A8L2Q1K4
      Conserved Domains (1) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    2. XM_063267053.1 → XP_063123123.1  PTB domain-containing engulfment adapter protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q0PYK2, Q5PQS4
      UniProtKB/TrEMBL
      A6INS9

    3. XM_039083457.2 → XP_038939385.1  PTB domain-containing engulfment adapter protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K2Q5
      Conserved Domains (1) summary
      cd01273
      Location:3 → 126
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    4. XM_017596394.3 → XP_017451883.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2Q5, A0A8L2Q1K4
      Related
      ENSRNOP00000004463.5
      Conserved Domains (1) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    5. XM_039083454.2 → XP_038939382.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2Q5, A0A8L2Q1K4
      Conserved Domains (1) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    6. XM_063267052.1 → XP_063123122.1  PTB domain-containing engulfment adapter protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q0PYK2, Q5PQS4
      UniProtKB/TrEMBL
      A6INS9

    7. XM_017596393.3 → XP_017451882.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2Q5, A0A8L2Q1K4
      Conserved Domains (1) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    8. XM_039083452.2 → XP_038939380.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2Q5, A0A8L2Q1K4
      Conserved Domains (1) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    9. XM_039083455.2 → XP_038939383.1  PTB domain-containing engulfment adapter protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q0PYK2, Q5PQS4
      UniProtKB/TrEMBL
      A0A0G2K2Q5, A6INS9
      Related
      ENSRNOP00000060050.4
      Conserved Domains (2) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
      cl40461
      Location:150 → 191
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    10. XM_063267051.1 → XP_063123121.1  PTB domain-containing engulfment adapter protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q0PYK2, Q5PQS4
      UniProtKB/TrEMBL
      A6INS9

    11. XM_039083453.2 → XP_038939381.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2Q5, A0A8L2Q1K4
      Conserved Domains (1) summary
      cd01273
      Location:14 → 157
      PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain

    12. XM_063267050.1 → XP_063123120.1  PTB domain-containing engulfment adapter protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q1K4

    13. XM_063267054.1 → XP_063123124.1  PTB domain-containing engulfment adapter protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q0PYK2, Q5PQS4
      UniProtKB/TrEMBL
      A6INS9

    14. XM_063267055.1 → XP_063123125.1  PTB domain-containing engulfment adapter protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q0PYK2, Q5PQS4
      UniProtKB/TrEMBL
      A6INS9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQS4.1 GenPept UniProtKB/Swiss-Prot:Q5PQS4

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