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    Gbp4 guanylate binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310917, updated on 30-Mar-2024

    Summary

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    Symbol
    Gbp4provided by RGD
    Full Name
    guanylate binding protein 4provided by RGD
    Primary source
    RGD:1310579
    See related
    Ensembl:ENSRNOG00000028768 AllianceGenome:RGD:1310579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Predicted to be involved in cellular response to interferon-gamma; defense response to Gram-positive bacterium; and defense response to protozoan. Predicted to act upstream of or within adhesion of symbiont to host and cellular response to interferon-beta. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and perinuclear region of cytoplasm. Predicted to be active in cytoplasmic vesicle. Orthologous to several human genes including GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 113.0), Thymus (RPKM 35.5) and 8 other tissues See more
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    Genomic context

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    See Gbp4 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (233978163..233992124)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (231304910..231318883)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (248249232..248263104)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 5 Neighboring gene guanylate binding protein 7 Neighboring gene guanylate binding protein 2 Neighboring gene uncharacterized LOC134485987

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. Degrandi D, et al. J Immunol, 2007 Dec 1. PMID 18025219
    2. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, et al. Science, 2011 May 6. PMID 21551061
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adhesion of symbiont to host ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytolysis in another organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to protozoan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to protozoan ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of pyroptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    guanylate-binding protein 4
    Names
    guanylate nucleotide binding protein 3
    guanylate nucleotide binding protein 4
    guanylate-binding protein 4-like
    NP_001292190.1
    XP_006233486.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305261.1 → NP_001292190.1  guanylate-binding protein 4

      See identical proteins and their annotated locations for NP_001292190.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HW65, A6HW67, D3ZQL3
      Related
      ENSRNOP00000022648.3, ENSRNOT00000022648.6
      Conserved Domains (3) summary
      pfam02841
      Location:277 → 573
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:12 → 275
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:283 → 573
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      233978163..233992124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233424.5 → XP_006233486.1  guanylate-binding protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006233486.1

      UniProtKB/TrEMBL
      A6HW65
      Conserved Domains (3) summary
      pfam02841
      Location:269 → 558
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:12 → 271
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:269 → 558
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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