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    KRT16 keratin 16 [ Homo sapiens (human) ]

    Gene ID: 3868, updated on 6-Jun-2017
    Official Symbol
    KRT16provided by HGNC
    Official Full Name
    keratin 16provided by HGNC
    Primary source
    HGNC:HGNC:6423
    See related
    Ensembl:ENSG00000186832 MIM:148067; Vega:OTTHUMG00000133495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    17q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (41609778..41612827, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39766030..39769079, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 9 Neighboring gene keratin 14 Neighboring gene keratin 17 Neighboring gene keratin 42 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Keratinization, organism-specific biosystem (from REACTOME)
      Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cornification TAS
    Traceable Author Statement
    more info
     
    cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    establishment of skin barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hair cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intermediate filament cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    keratinization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    keratinization TAS
    Traceable Author Statement
    more info
     
    keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    keratinocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    morphogenesis of an epithelium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    keratin, type I cytoskeletal 16
    Names
    cytokeratin 16
    focal non-epidermolytic palmoplantar keratoderma
    keratin 16, type I

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008301.1 RefSeqGene

      Range
      5001..8050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005557.3NP_005548.2  keratin, type I cytoskeletal 16

      See identical proteins and their annotated locations for NP_005548.2

      Status: REVIEWED

      Source sequence(s)
      AK290853, BC039169, DC394235
      Consensus CDS
      CCDS11401.1
      UniProtKB/Swiss-Prot
      P08779
      Related
      ENSP00000301653.3, OTTHUMP00000164740, ENST00000301653.8, OTTHUMT00000257408
      Conserved Domains (2) summary
      pfam00038
      Location:116427
      Filament; Intermediate filament protein
      cl14876
      Location:239327
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      41609778..41612827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      40001344..40004393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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