Format

Send to:

Choose Destination
    • Showing Current items.

    KRT15 keratin 15 [ Homo sapiens (human) ]

    Gene ID: 3866, updated on 20-Apr-2017
    Official Symbol
    KRT15provided by HGNC
    Official Full Name
    keratin 15provided by HGNC
    Primary source
    HGNC:HGNC:6421
    See related
    Ensembl:ENSG00000171346 MIM:148030; Vega:OTTHUMG00000133435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K15; CK15; K1CO
    Summary
    The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    17q21.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (41513745..41522413, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39669997..39678033, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 36 Neighboring gene keratin 13 Neighboring gene microRNA 6510 Neighboring gene keratin 19 Neighboring gene long intergenic non-protein coding RNA 974

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Keratinization, organism-specific biosystem (from REACTOME)
      Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cornification TAS
    Traceable Author Statement
    more info
     
    cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    keratinization TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    keratin, type I cytoskeletal 15
    Names
    CK-15
    cytokeratin 15
    keratin 15, type I
    keratin-15, basic
    keratin-15, beta
    type I cytoskeletal 15

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012284.1 RefSeqGene

      Range
      5001..10274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002275.3NP_002266.2  keratin, type I cytoskeletal 15

      See identical proteins and their annotated locations for NP_002266.2

      Status: REVIEWED

      Source sequence(s)
      AK122864, BC002641, BC110649
      Consensus CDS
      CCDS11398.1
      UniProtKB/Swiss-Prot
      P19012
      UniProtKB/TrEMBL
      B3KVF5
      Related
      ENSP00000254043.3, OTTHUMP00000164634, ENST00000254043.7, OTTHUMT00000257301
      Conserved Domains (1) summary
      pfam00038
      Location:104416
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      41513745..41522413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024614.1XP_016880103.1  keratin, type I cytoskeletal 15 isoform X2

      Conserved Domains (1) summary
      pfam00038
      Location:104423
      Filament; Intermediate filament protein
    2. XM_011524784.2XP_011523086.1  keratin, type I cytoskeletal 15 isoform X1

      Conserved Domains (1) summary
      pfam00038
      Location:104423
      Filament; Intermediate filament protein

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      39905306..39910579 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center