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    Arhgap39 Rho GTPase activating protein 39 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500901, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Arhgap39provided by RGD
    Official Full Name
    Rho GTPase activating protein 39provided by RGD
    Primary source
    RGD:1593158
    See related
    Ensembl:ENSRNOG00000016566 AllianceGenome:RGD:1593158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Porf-2
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in postsynapse organization. Is active in glutamatergic synapse and postsynapse. Orthologous to human ARHGAP39 (Rho GTPase activating protein 39). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 66.1), Spleen (RPKM 57.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110326918..110419500, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108446280..108538875, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117788716..117880329, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene RecQ like helicase 4 Neighboring gene leucine rich repeat containing 14 Neighboring gene similar to human chromosome 8 open reading frame 82 Neighboring gene leucine rich repeat containing 24 Neighboring gene uncharacterized LOC134479930 Neighboring gene zinc finger protein 251

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of two hypothalamic cDNAs encoding tissue-specific transcripts in the preoptic area and testis. Nowak FV. Mol Endocrinol, 1990 Aug. PMID 2293025
    2. The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons. Lim J, et al. Curr Biol, 2014 Mar 31. PMID 24656827, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1688

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho GTPase-activating protein 39
    Names
    preoptic regulatory factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173122.3 → NP_775145.2  rho GTPase-activating protein 39

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HSD4, F1LR18
      Related
      ENSRNOP00000051450.3, ENSRNOT00000052227.4
      Conserved Domains (3) summary
      PRK10263
      Location:219 → 378
      PRK10263; DNA translocase FtsK; Provisional
      cd04389
      Location:914 → 1099
      RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
      pfam00784
      Location:762 → 903
      MyTH4; MyTH4 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      110326918..110419500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241866.5 → XP_006241928.1  rho GTPase-activating protein 39 isoform X2

      UniProtKB/TrEMBL
      A6HSD4
      Conserved Domains (2) summary
      cd04389
      Location:886 → 1071
      RhoGAP_KIAA1688; RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into ...
      cl02480
      Location:689 → 874
      MyTH4; MyTH4 domain

    2. XM_006241867.5 → XP_006241929.1  rho GTPase-activating protein 39 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y0P2, A6HSD4
      Related
      ENSRNOP00000076721.1
      Conserved Domains (3) summary
      PRK10263
      Location:219 → 378
      PRK10263; DNA translocase FtsK; Provisional
      cd04389
      Location:883 → 1068
      RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
      pfam00784
      Location:762 → 872
      MyTH4; MyTH4 domain

    3. XM_017595054.3 → XP_017450543.1  rho GTPase-activating protein 39 isoform X1

      UniProtKB/TrEMBL
      A6HSD4, F1LR18
      Conserved Domains (3) summary
      PRK10263
      Location:219 → 378
      PRK10263; DNA translocase FtsK; Provisional
      cd04389
      Location:914 → 1099
      RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
      pfam00784
      Location:762 → 903
      MyTH4; MyTH4 domain

    4. XM_039079761.2 → XP_038935689.1  rho GTPase-activating protein 39 isoform X1

      UniProtKB/TrEMBL
      A6HSD4, F1LR18
      Conserved Domains (3) summary
      PRK10263
      Location:219 → 378
      PRK10263; DNA translocase FtsK; Provisional
      cd04389
      Location:914 → 1099
      RhoGAP_KIAA1688; GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, ...
      pfam00784
      Location:762 → 903
      MyTH4; MyTH4 domain

    5. XM_063264134.1 → XP_063120204.1  rho GTPase-activating protein 39 isoform X4

    6. XM_063264135.1 → XP_063120205.1  rho GTPase-activating protein 39 isoform X7

    7. XM_039079762.2 → XP_038935690.1  rho GTPase-activating protein 39 isoform X5

      Conserved Domains (2) summary
      PRK10263
      Location:219 → 378
      PRK10263; DNA translocase FtsK; Provisional
      pfam00784
      Location:762 → 891
      MyTH4; MyTH4 domain

    8. XM_017595056.3 → XP_017450545.2  rho GTPase-activating protein 39 isoform X6

      Conserved Domains (2) summary
      PRK10263
      Location:219 → 378
      PRK10263; DNA translocase FtsK; Provisional
      pfam00784
      Location:762 → 846
      MyTH4; MyTH4 domain

    RNA

    1. XR_005486709.2 RNA Sequence

    2. XR_005486708.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18890.2 GenPept UniProtKB/Swiss-Prot:P18890

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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