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    Zfp143 zinc finger protein 143 [ Mus musculus (house mouse) ]

    Gene ID: 20841, updated on 27-Nov-2024

    Summary

    Official Symbol
    Zfp143provided by MGI
    Official Full Name
    zinc finger protein 143provided by MGI
    Primary source
    MGI:MGI:1277969
    See related
    Ensembl:ENSMUSG00000061079 AllianceGenome:MGI:1277969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SBF; Staf; Zfp79; pHZ-1; KRAB14; Znf143; Zfp80-rs1; D7Ertd805e
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of smooth muscle cell proliferation and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be part of PcG protein complex and transcription regulator complex. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF143 (zinc finger protein 143). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 6.7), CNS E11.5 (RPKM 6.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zfp143 in Genome Data Viewer
    Location:
    7 E3; 7 57.7 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109660898..109694603)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (110061689..110095396)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25636 Neighboring gene importin 7 Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene STARR-seq mESC enhancer starr_19814 Neighboring gene STARR-seq mESC enhancer starr_19815 Neighboring gene STARR-positive B cell enhancer ABC_E293 Neighboring gene STARR-positive B cell enhancer ABC_E6584 Neighboring gene WEE 1 homolog 1 (S. pombe) Neighboring gene VISTA enhancer mm725 Neighboring gene STARR-seq mESC enhancer starr_19821 Neighboring gene predicted gene, 51505

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of PcG protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 143
    Names
    mStaf
    selenocysteine tRNA gene transcription-activating factor
    zfp-143
    zinc finger protein 80, related sequence 1
    NP_001361547.1
    NP_001392700.1
    NP_001392701.1
    NP_033307.2
    XP_036008747.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374618.1NP_001361547.1  zinc finger protein 143 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC147244
      Consensus CDS
      CCDS90307.1
      UniProtKB/Swiss-Prot
      O70230, Q8BGB0, Q8CEI6, Q8CI27
      Related
      ENSMUSP00000081778.5, ENSMUST00000084727.11
      Conserved Domains (3) summary
      COG5048
      Location:251424
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:207292
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:239261
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001405771.1NP_001392700.1  zinc finger protein 143 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC147244
      UniProtKB/Swiss-Prot
      O70230, Q8BGB0, Q8CEI6, Q8CI27
    3. NM_001405772.1NP_001392701.1  zinc finger protein 143 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC147244
    4. NM_009281.4NP_033307.2  zinc finger protein 143 isoform 2

      See identical proteins and their annotated locations for NP_033307.2

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC147244
      Consensus CDS
      CCDS57580.1
      UniProtKB/Swiss-Prot
      O70230
      Related
      ENSMUSP00000148235.2, ENSMUST00000211798.2
      Conserved Domains (3) summary
      COG5048
      Location:250423
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:206291
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:238260
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      109660898..109694603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152854.1XP_036008747.1  zinc finger protein 143 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:48221
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:489
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:3658
      ZF_C2H2; C2H2 Zn finger [structural motif]