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    ZNF711 zinc finger protein 711 [ Homo sapiens (human) ]

    Gene ID: 7552, updated on 18-Sep-2024

    Summary

    Official Symbol
    ZNF711provided by HGNC
    Official Full Name
    zinc finger protein 711provided by HGNC
    Primary source
    HGNC:HGNC:13128
    See related
    Ensembl:ENSG00000147180 MIM:314990; AllianceGenome:HGNC:13128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF4; ZNF5; ZNF6; CMPX1; MRX65; MRX97; XLID97; Zfp711; dJ75N13.1
    Summary
    This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with cognitive disability. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 23.7), brain (RPKM 10.7) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF711 in Genome Data Viewer
    Location:
    Xq21.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (85243991..85273357)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (83672840..83701879)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (84498997..84528363)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene apolipoprotein O like Neighboring gene spermidine/spermine N1-acetyl transferase like 1 Neighboring gene uncharacterized LOC101928128 Neighboring gene POF1B actin binding protein Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:84682018-84682570 Neighboring gene microRNA 1321

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Intellectual disability, X-linked 97
    MedGen: C2749020 OMIM: 300803 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2024-05-14)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2024-05-14)

    ClinGen Genome Curation PagePubMed

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 711
    Names
    dJ75N13.1 (znf6-like)
    zinc finger protein 6 (CMPX1)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012535.1 RefSeqGene

      Range
      5001..34367
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001330574.2NP_001317503.1  zinc finger protein 711 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC003001
      Consensus CDS
      CCDS83481.1
      UniProtKB/Swiss-Prot
      Q9Y462
      Related
      ENSP00000502839.1, ENST00000674551.1
      Conserved Domains (4) summary
      COG5048
      Location:546803
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:553573
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:429451
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65414
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    2. NM_001375431.1NP_001362360.1  zinc finger protein 711 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC003001
      Consensus CDS
      CCDS83481.1
      Conserved Domains (4) summary
      COG5048
      Location:546803
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:553573
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:429451
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65414
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    3. NM_001375432.1NP_001362361.1  zinc finger protein 711 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC003001
      Consensus CDS
      CCDS83481.1
      Conserved Domains (4) summary
      COG5048
      Location:546803
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:553573
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:429451
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65414
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    4. NM_001375433.1NP_001362362.1  zinc finger protein 711 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC003001
      Consensus CDS
      CCDS83481.1
      Conserved Domains (4) summary
      COG5048
      Location:546803
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:553573
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:429451
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65414
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    5. NM_001375434.1NP_001362363.1  zinc finger protein 711 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC003001
      Consensus CDS
      CCDS35344.1
      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
      Conserved Domains (4) summary
      COG5048
      Location:500757
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:383405
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65368
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    6. NM_001375435.1NP_001362364.1  zinc finger protein 711 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC003001
      Consensus CDS
      CCDS35344.1
      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
      Conserved Domains (4) summary
      COG5048
      Location:500757
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:383405
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65368
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    7. NM_001375436.1NP_001362365.1  zinc finger protein 711 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC003001
      Consensus CDS
      CCDS35344.1
      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
      Conserved Domains (4) summary
      COG5048
      Location:500757
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:383405
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65368
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    8. NM_001375437.1NP_001362366.1  zinc finger protein 711 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC003001
      Consensus CDS
      CCDS35344.1
      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
      Related
      ENSP00000276123.3, ENST00000276123.7
      Conserved Domains (4) summary
      COG5048
      Location:500757
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:383405
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65368
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    9. NM_021998.5NP_068838.3  zinc finger protein 711 isoform 2

      See identical proteins and their annotated locations for NP_068838.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BC006349, BC067294, DB074057
      Consensus CDS
      CCDS35344.1
      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
      Related
      ENSP00000362260.3, ENST00000373165.7
      Conserved Domains (4) summary
      COG5048
      Location:500757
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:383405
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65368
      Zfx_Zfy_act; Zfx / Zfy transcription activation region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      85243991..85273357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442469.1XP_047298425.1  zinc finger protein 711 isoform X4

      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
    2. XM_047442465.1XP_047298421.1  zinc finger protein 711 isoform X2

    3. XM_047442467.1XP_047298423.1  zinc finger protein 711 isoform X4

      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
    4. XM_011531019.2XP_011529321.1  zinc finger protein 711 isoform X1

      See identical proteins and their annotated locations for XP_011529321.1

      Conserved Domains (4) summary
      COG5048
      Location:550807
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:557577
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:433455
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:69418
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    5. XM_011531025.2XP_011529327.1  zinc finger protein 711 isoform X3

      Conserved Domains (5) summary
      COG5048
      Location:504761
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:511531
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:509531
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:69372
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
      pfam13465
      Location:523547
      zf-H2C2_2; Zinc-finger double domain
    6. XM_011531021.2XP_011529323.1  zinc finger protein 711 isoform X1

      See identical proteins and their annotated locations for XP_011529323.1

      Conserved Domains (4) summary
      COG5048
      Location:550807
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:557577
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:433455
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:69418
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    7. XM_011531020.2XP_011529322.1  zinc finger protein 711 isoform X1

      See identical proteins and their annotated locations for XP_011529322.1

      Conserved Domains (4) summary
      COG5048
      Location:550807
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:557577
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:433455
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:69418
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    8. XM_011531022.2XP_011529324.1  zinc finger protein 711 isoform X1

      See identical proteins and their annotated locations for XP_011529324.1

      Conserved Domains (4) summary
      COG5048
      Location:550807
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:557577
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:433455
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:69418
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    9. XM_005262187.2XP_005262244.1  zinc finger protein 711 isoform X2

      See identical proteins and their annotated locations for XP_005262244.1

      UniProtKB/Swiss-Prot
      Q9Y462
      Conserved Domains (4) summary
      COG5048
      Location:546803
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:553573
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:429451
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65414
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    10. XM_011531023.4XP_011529325.1  zinc finger protein 711 isoform X1

      See identical proteins and their annotated locations for XP_011529325.1

      Conserved Domains (4) summary
      COG5048
      Location:550807
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:557577
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:433455
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:69418
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    11. XM_005262188.2XP_005262245.1  zinc finger protein 711 isoform X2

      See identical proteins and their annotated locations for XP_005262245.1

      UniProtKB/Swiss-Prot
      Q9Y462
      Conserved Domains (4) summary
      COG5048
      Location:546803
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:553573
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:429451
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65414
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    12. XM_047442462.1XP_047298418.1  zinc finger protein 711 isoform X1

    13. XM_017029809.2XP_016885298.1  zinc finger protein 711 isoform X4

      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
      Conserved Domains (4) summary
      COG5048
      Location:500757
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:507527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:383405
      zf-C2H2; Zinc finger, C2H2 type
      pfam04704
      Location:65368
      Zfx_Zfy_act; Zfx / Zfy transcription activation region
    14. XM_047442464.1XP_047298420.1  zinc finger protein 711 isoform X2

      Related
      ENSP00000353922.4, ENST00000360700.4
    15. XM_047442468.1XP_047298424.1  zinc finger protein 711 isoform X4

      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
    16. XM_047442470.1XP_047298426.1  zinc finger protein 711 isoform X4

      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
    17. XM_047442466.1XP_047298422.1  zinc finger protein 711 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      83672840..83701879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327776.1XP_054183751.1  zinc finger protein 711 isoform X4

      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
    2. XM_054327769.1XP_054183744.1  zinc finger protein 711 isoform X2

    3. XM_054327774.1XP_054183749.1  zinc finger protein 711 isoform X4

      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
    4. XM_054327762.1XP_054183737.1  zinc finger protein 711 isoform X1

    5. XM_054327773.1XP_054183748.1  zinc finger protein 711 isoform X3

    6. XM_054327764.1XP_054183739.1  zinc finger protein 711 isoform X1

    7. XM_054327763.1XP_054183738.1  zinc finger protein 711 isoform X1

    8. XM_054327765.1XP_054183740.1  zinc finger protein 711 isoform X1

    9. XM_054327772.1XP_054183747.1  zinc finger protein 711 isoform X2

    10. XM_054327766.1XP_054183741.1  zinc finger protein 711 isoform X1

    11. XM_054327770.1XP_054183745.1  zinc finger protein 711 isoform X2

    12. XM_054327767.1XP_054183742.1  zinc finger protein 711 isoform X1

    13. XM_054327777.1XP_054183752.1  zinc finger protein 711 isoform X4

      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
    14. XM_054327768.1XP_054183743.1  zinc finger protein 711 isoform X2

    15. XM_054327775.1XP_054183750.1  zinc finger protein 711 isoform X4

      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
    16. XM_054327778.1XP_054183753.1  zinc finger protein 711 isoform X4

      UniProtKB/Swiss-Prot
      B4DSV4, Q6NX42, Q9Y462, Q9Y4J6
    17. XM_054327771.1XP_054183746.1  zinc finger protein 711 isoform X2