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    Tef thyrotroph embryonic factor [ Mus musculus (house mouse) ]

    Gene ID: 21685, updated on 2-Nov-2024

    Summary

    Official Symbol
    Tefprovided by MGI
    Official Full Name
    thyrotroph embryonic factorprovided by MGI
    Primary source
    MGI:MGI:98663
    See related
    Ensembl:ENSMUSG00000022389 AllianceGenome:MGI:98663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310028D20Rik
    Summary
    Enables double-stranded DNA binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; early conceptus; genitourinary system; and trunk somite. Orthologous to human TEF (TEF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 46.8), bladder adult (RPKM 43.9) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tef in Genome Data Viewer
    Location:
    15 E1; 15 38.25 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81686874..81711064)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81802673..81826863)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 7B Neighboring gene STARR-seq mESC enhancer starr_39269 Neighboring gene predicted gene, 17597 Neighboring gene STARR-positive B cell enhancer ABC_E944 Neighboring gene STARR-positive B cell enhancer ABC_E8940 Neighboring gene STARR-positive B cell enhancer ABC_E8599 Neighboring gene predicted gene 8444 Neighboring gene STARR-positive B cell enhancer ABC_E7399 Neighboring gene STARR-positive B cell enhancer ABC_E481 Neighboring gene transducer of ERBB2, 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    thyrotroph embryonic factor
    Names
    thyrotrophic embryonic factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017376.3NP_059072.1  thyrotroph embryonic factor isoform 1

      See identical proteins and their annotated locations for NP_059072.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK147965, AY540631, BP764162, BY336350
      Consensus CDS
      CCDS27672.1
      UniProtKB/Swiss-Prot
      Q3U426, Q3UGF4, Q3UM49, Q3URC8, Q6QHT6, Q8C6I0, Q8VD02, Q9JLC6
      UniProtKB/TrEMBL
      Q3V3B6
      Related
      ENSMUSP00000023024.8, ENSMUST00000023024.8
      Conserved Domains (1) summary
      cd14695
      Location:230288
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    2. NM_153484.3NP_705617.2  thyrotroph embryonic factor isoform 2

      See identical proteins and their annotated locations for NP_705617.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' coding exon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK141606, AK147965, BP764162, BY296040
      Consensus CDS
      CCDS27671.2
      UniProtKB/TrEMBL
      Q3V3B6
      Related
      ENSMUSP00000105180.3, ENSMUST00000109553.10
      Conserved Domains (1) summary
      cd14695
      Location:214272
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      81686874..81711064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245558.4XP_011243860.1  thyrotroph embryonic factor isoform X2

      See identical proteins and their annotated locations for XP_011243860.1

      UniProtKB/TrEMBL
      Q3V3B6
      Conserved Domains (1) summary
      cd14695
      Location:253311
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    2. XM_011245557.4XP_011243859.1  thyrotroph embryonic factor isoform X1

      Conserved Domains (1) summary
      cd14695
      Location:269327
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    3. XM_011245560.3XP_011243862.1  thyrotroph embryonic factor isoform X3

      See identical proteins and their annotated locations for XP_011243862.1

      UniProtKB/TrEMBL
      Q3V3B6
      Conserved Domains (1) summary
      cd14695
      Location:200258
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    4. XM_006520744.2XP_006520807.1  thyrotroph embryonic factor isoform X4

      UniProtKB/TrEMBL
      Q3V3B6
      Conserved Domains (1) summary
      cd14695
      Location:161219
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    5. XM_036159316.1XP_036015209.1  thyrotroph embryonic factor isoform X6

      Conserved Domains (1) summary
      cd14695
      Location:110168
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    6. XM_030248461.2XP_030104321.1  thyrotroph embryonic factor isoform X6

      Conserved Domains (1) summary
      cd14695
      Location:110168
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    7. XM_011245559.3XP_011243861.1  thyrotroph embryonic factor isoform X3

      See identical proteins and their annotated locations for XP_011243861.1

      UniProtKB/TrEMBL
      Q3V3B6
      Conserved Domains (1) summary
      cd14695
      Location:200258
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    8. XM_030248460.2XP_030104320.1  thyrotroph embryonic factor isoform X4

      UniProtKB/TrEMBL
      Q3V3B6
      Conserved Domains (1) summary
      cd14695
      Location:161219
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    9. XM_036159315.1XP_036015208.1  thyrotroph embryonic factor isoform X5

      Conserved Domains (1) summary
      cd14695
      Location:119177
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain