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    Tcf7 transcription factor 7, T cell specific [ Mus musculus (house mouse) ]

    Gene ID: 21414, updated on 18-Sep-2024

    Summary

    Official Symbol
    Tcf7provided by MGI
    Official Full Name
    transcription factor 7, T cell specificprovided by MGI
    Primary source
    MGI:MGI:98507
    See related
    Ensembl:ENSMUSG00000000782 AllianceGenome:MGI:98507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcf1; TCF-1
    Summary
    This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in thymus adult (RPKM 829.6) and spleen adult (RPKM 56.0) See more
    Orthologs
    NEW
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    Genomic context

    See Tcf7 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.86 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (52137347..52174211, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52246527..52283383, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12206 Neighboring gene STARR-seq mESC enhancer starr_29443 Neighboring gene STARR-seq mESC enhancer starr_29444 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52045093-52045276 Neighboring gene STARR-positive B cell enhancer ABC_E8401 Neighboring gene olfactory receptor family 2 subfamily Y member 6 Neighboring gene S-phase kinase-associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_29449 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52096181-52096290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52097872-52098055 Neighboring gene STARR-seq mESC enhancer starr_29452 Neighboring gene STARR-seq mESC enhancer starr_29453 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52132162-52132271 Neighboring gene predicted gene, 30217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52152988-52153277 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52154886-52154995 Neighboring gene STARR-positive B cell enhancer ABC_E11479 Neighboring gene STARR-seq mESC enhancer starr_29458 Neighboring gene voltage-dependent anion channel 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell receptor V(D)J recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within alpha-beta T cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway involved in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to interleukin-4 ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic digestive tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic genitalia morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hindgut morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in gamma-delta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of gamma-delta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription factor 7
    Names
    T-cell-specific transcription factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313981.2NP_001300910.2  transcription factor 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL645862
      UniProtKB/Swiss-Prot
      Q00417
      UniProtKB/TrEMBL
      A0A5K1VVQ7
      Related
      ENSMUSP00000104699.3, ENSMUST00000109071.3
    2. NM_001427422.1NP_001414351.1  transcription factor 7 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL645862
    3. NM_001427423.1NP_001414352.1  transcription factor 7 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL645862
      UniProtKB/Swiss-Prot
      Q00417
    4. NM_001427424.1NP_001414353.1  transcription factor 7 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL645862
      UniProtKB/Swiss-Prot
      Q00417
    5. NM_001427425.1NP_001414354.1  transcription factor 7 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL645862
      UniProtKB/Swiss-Prot
      Q00417
    6. NM_001427426.1NP_001414355.1  transcription factor 7 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL645862
    7. NM_009331.5NP_033357.1  transcription factor 7 isoform 2

      See identical proteins and their annotated locations for NP_033357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform 2.
      Source sequence(s)
      AL645862
      Consensus CDS
      CCDS24670.1
      UniProtKB/TrEMBL
      B7ZNN3, Q80UF1
      Related
      ENSMUSP00000084055.4, ENSMUST00000086844.10
      Conserved Domains (2) summary
      cd01388
      Location:188258
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:1100
      CTNNB1_binding; N-terminal CTNNB1 binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      52137347..52174211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245766.2XP_030101626.1  transcription factor 7 isoform X1

      Conserved Domains (2) summary
      cd01388
      Location:304374
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:20216
      CTNNB1_binding; N-terminal CTNNB1 binding
    2. XM_030245769.2XP_030101629.1  transcription factor 7 isoform X3

      UniProtKB/Swiss-Prot
      Q00417
      Conserved Domains (2) summary
      cd01388
      Location:304374
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
      pfam08347
      Location:20216
      CTNNB1_binding; N-terminal CTNNB1 binding
    3. XM_030245773.2XP_030101633.1  transcription factor 7 isoform X7

      Conserved Domains (1) summary
      cd01388
      Location:98168
      SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...