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    Tbx19 T-box 19 [ Mus musculus (house mouse) ]

    Gene ID: 83993, updated on 18-Sep-2024

    Summary

    Official Symbol
    Tbx19provided by MGI
    Official Full Name
    T-box 19provided by MGI
    Primary source
    MGI:MGI:1891158
    See related
    Ensembl:ENSMUSG00000026572 AllianceGenome:MGI:1891158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tpit; D1Ertd754e
    Summary
    This gene encodes a member of a family of transcription factors containing a characteristic T-box DNA-binding domain. The encoded protein promotes expression of the pro-opiomelanocortin (POMC) gene, which is important for the differentiation of cells in the pituitary gland. [provided by RefSeq, Mar 2013]
    Expression
    Biased expression in testis adult (RPKM 6.3) and thymus adult (RPKM 2.4) See more
    Orthologs
    NEW
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    Genomic context

    See Tbx19 in Genome Data Viewer
    Location:
    1 H2.2; 1 72.47 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (164965403..164988342, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165137834..165160773, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51669 Neighboring gene RIKEN cDNA 4930568G15 gene Neighboring gene STARR-positive B cell enhancer ABC_E9492 Neighboring gene STARR-seq mESC enhancer starr_02894 Neighboring gene SFT2 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_02896 Neighboring gene TIP41, TOR signalling pathway regulator-like (S. cerevisiae) Neighboring gene G protein-coupled receptor 161

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    T-box transcription factor TBX19
    Names
    T-box factor, pituitary
    T-box protein 19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032005.4NP_114394.1  T-box transcription factor TBX19

      See identical proteins and their annotated locations for NP_114394.1

      Status: REVIEWED

      Source sequence(s)
      AK038666, AU019700
      Consensus CDS
      CCDS15439.1
      UniProtKB/Swiss-Prot
      Q0VBH2, Q99ME7
      Related
      ENSMUSP00000027859.6, ENSMUST00000027859.12
      Conserved Domains (1) summary
      smart00425
      Location:39221
      TBOX; Domain first found in the mice T locus (Brachyury) protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      164965403..164988342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497043.3XP_006497106.1  T-box transcription factor TBX19 isoform X1

      UniProtKB/TrEMBL
      F6USC6
      Related
      ENSMUSP00000123909.2, ENSMUST00000161144.2
      Conserved Domains (1) summary
      pfam00907
      Location:1149
      T-box