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    Tal1 T cell acute lymphocytic leukemia 1 [ Mus musculus (house mouse) ]

    Gene ID: 21349, updated on 18-Sep-2024

    Summary

    Official Symbol
    Tal1provided by MGI
    Official Full Name
    T cell acute lymphocytic leukemia 1provided by MGI
    Primary source
    MGI:MGI:98480
    See related
    Ensembl:ENSMUSG00000028717 AllianceGenome:MGI:98480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hpt; Scl; tal-1; bHLHa17; SCL/tal-1
    Summary
    Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and transmembrane receptor protein tyrosine kinase activator activity. Contributes to DNA binding activity. Involved in embryonic hemopoiesis; positive regulation of erythrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; neurogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; hemolymphoid system; and sensory organ. Used to study lymphoid leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14.5 (RPKM 43.3), liver E14 (RPKM 39.2) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tal1 in Genome Data Viewer
    Location:
    4 D1; 4 52.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114913623..114928952)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115056426..115071755)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:114672416-114672599 Neighboring gene STARR-seq mESC enhancer starr_11107 Neighboring gene Scl/Tal1 interrupting locus Neighboring gene predicted gene, 52674 Neighboring gene predicted gene, 33786 Neighboring gene PDZK1 interacting protein 1 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1 Neighboring gene cytochrome P450, family 4, subfamily x, polypeptide 1, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within astrocyte fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in basophil differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_negative_effect erythrocyte differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemangioblast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within megakaryocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within platelet formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within spinal cord association neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_positive_effect transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    T-cell acute lymphocytic leukemia protein 1 homolog
    Names
    stem cell protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287388.2NP_001274317.1  T-cell acute lymphocytic leukemia protein 1 homolog

      See identical proteins and their annotated locations for NP_001274317.1

      Status: VALIDATED

      Source sequence(s)
      AL670035
      Consensus CDS
      CCDS18486.1
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
      Related
      ENSMUSP00000125202.2, ENSMUST00000161601.8
      Conserved Domains (1) summary
      cd19706
      Location:185249
      bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins
    2. NM_001425779.1NP_001412708.1  T-cell acute lymphocytic leukemia protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AL670035
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
    3. NM_001425780.1NP_001412709.1  T-cell acute lymphocytic leukemia protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AL670035
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
    4. NM_001425781.1NP_001412710.1  T-cell acute lymphocytic leukemia protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AL670035
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
    5. NM_001425782.1NP_001412711.1  T-cell acute lymphocytic leukemia protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AL670035
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
    6. NM_001425783.1NP_001412712.1  T-cell acute lymphocytic leukemia protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AL670035
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
    7. NM_001425784.1NP_001412713.1  T-cell acute lymphocytic leukemia protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AL670035
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
    8. NM_001425785.1NP_001412714.1  T-cell acute lymphocytic leukemia protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AL670035
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
    9. NM_001425786.1NP_001412715.1  T-cell acute lymphocytic leukemia protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AL670035
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
    10. NM_001425787.1NP_001412716.1  T-cell acute lymphocytic leukemia protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AL670035
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
      Related
      ENSMUSP00000124983.2, ENSMUST00000162489.2
    11. NM_001425788.1NP_001412717.1  T-cell acute lymphocytic leukemia protein 1 homolog

      Status: VALIDATED

      Source sequence(s)
      AL670035
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
    12. NM_011527.4NP_035657.1  T-cell acute lymphocytic leukemia protein 1 homolog

      See identical proteins and their annotated locations for NP_035657.1

      Status: VALIDATED

      Source sequence(s)
      AL670035
      Consensus CDS
      CCDS18486.1
      UniProtKB/Swiss-Prot
      P22091
      UniProtKB/TrEMBL
      Q3TZH7, Q9JK33
      Related
      ENSMUSP00000030489.3, ENSMUST00000030489.9
      Conserved Domains (1) summary
      cd19706
      Location:185249
      bHLH_TS_TAL1; basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      114913623..114928952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)