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Taf1 TATA-box binding protein associated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 270627, updated on 18-Sep-2024

Summary

Official Symbol
Taf1provided by MGI
Official Full Name
TATA-box binding protein associated factor 1provided by MGI
Primary source
MGI:MGI:1336878
See related
Ensembl:ENSMUSG00000031314 AllianceGenome:MGI:1336878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccg1; KAT4; p250; Ccg-1; Taf2a; N-TAF1; TAFII250; B430306D02Rik
Summary
Enables DNA binding activity; histone acetyltransferase activity; and promoter-specific chromatin binding activity. Involved in histone acetylation. Located in pronucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to several human genes including TAF1 (TATA-box binding protein associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 8.6), CNS E14 (RPKM 5.7) and 22 other tissues See more
Orthologs
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Genomic context

See Taf1 in Genome Data Viewer
Location:
X D; X 44.29 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100576335..100644635)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101527572..101601789)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47650 Neighboring gene anaphase promoting complex subunit 13 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2537 Neighboring gene ring finger protein 26 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47657 Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Neighboring gene STARR-seq mESC enhancer starr_47659 Neighboring gene RNA binding protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to H3K27me3 modified histone binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase I general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA polymerase II preinitiation complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription initiation by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nucleolus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 1
Names
TBP-associated factor 250 kDa
cell cycle gene 1 protein
cell cycle, G1 phase defect
transcription initiation factor TFIID 250 kDa subunit
NP_001277658.2
NP_001392888.2
NP_001392889.2
NP_001392890.2
NP_001392891.2
XP_006528114.1
XP_017174001.1
XP_017174002.1
XP_017174004.1
XP_017174005.1
XP_017174007.1
XP_036017866.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290729.3NP_001277658.2  transcription initiation factor TFIID subunit 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL806534, AL831722
    Consensus CDS
    CCDS85793.1
    UniProtKB/TrEMBL
    A0A067XG50, B1Q2W7
    Related
    ENSMUSP00000114765.3, ENSMUST00000149274.9
  2. NM_001405959.2NP_001392888.2  transcription initiation factor TFIID subunit 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL806534, AL831722
    UniProtKB/Swiss-Prot
    A2AM32, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q80UV9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
    Related
    ENSMUSP00000138159.2, ENSMUST00000143908.8
  3. NM_001405960.2NP_001392889.2  transcription initiation factor TFIID subunit 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL806534, AL831722
    UniProtKB/Swiss-Prot
    A2AM32, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q80UV9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
    Related
    ENSMUSP00000160012.1, ENSMUST00000249914.1
  4. NM_001405961.2NP_001392890.2  transcription initiation factor TFIID subunit 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL806534, AL831722
    UniProtKB/Swiss-Prot
    A2AM32, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q80UV9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
  5. NM_001405962.2NP_001392891.2  transcription initiation factor TFIID subunit 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL806534, AL831722
    UniProtKB/Swiss-Prot
    A2AM32, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q80UV9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    100576335..100644635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161973.1XP_036017866.1  transcription initiation factor TFIID subunit 1 isoform X9

    UniProtKB/TrEMBL
    S4R1B9
    Conserved Domains (4) summary
    cd05511
    Location:15331645
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:2886
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5911054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12871322
    zf-CCHC_6; Zinc knuckle
  2. XM_017318518.3XP_017174007.1  transcription initiation factor TFIID subunit 1 isoform X10

    UniProtKB/TrEMBL
    S4R1B9
    Conserved Domains (5) summary
    cd05511
    Location:14111522
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:2886
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5911054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12871322
    zf-CCHC_6; Zinc knuckle
    cl02556
    Location:15331612
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
  3. XM_017318512.2XP_017174001.1  transcription initiation factor TFIID subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A067XG50, B1Q2W7
    Conserved Domains (4) summary
    cd05511
    Location:15331645
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:2886
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5911054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12871322
    zf-CCHC_6; Zinc knuckle
  4. XM_017318515.3XP_017174004.1  transcription initiation factor TFIID subunit 1 isoform X6

    UniProtKB/TrEMBL
    A0A067XG50, B1Q2W7
    Conserved Domains (4) summary
    cd05511
    Location:15331645
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:2886
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5911054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12871322
    zf-CCHC_6; Zinc knuckle
  5. XM_017318513.3XP_017174002.1  transcription initiation factor TFIID subunit 1 isoform X2

    UniProtKB/Swiss-Prot
    A2AM32, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q80UV9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
    Conserved Domains (4) summary
    cd05511
    Location:15331645
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:2886
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5911054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12871322
    zf-CCHC_6; Zinc knuckle
  6. XM_017318516.3XP_017174005.1  transcription initiation factor TFIID subunit 1 isoform X7

    UniProtKB/Swiss-Prot
    A2AM32, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q80UV9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
    Conserved Domains (4) summary
    cd05511
    Location:15331645
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:2886
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5911054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12871322
    zf-CCHC_6; Zinc knuckle
  7. XM_006528051.4XP_006528114.1  transcription initiation factor TFIID subunit 1 isoform X4

    UniProtKB/TrEMBL
    A0A067XG50, B1Q2W7
    Conserved Domains (4) summary
    cd05511
    Location:15071619
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:2886
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:5651028
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:12611296
    zf-CCHC_6; Zinc knuckle

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081008.1: Suppressed sequence

    Description
    NM_001081008.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.