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    TFDP1 transcription factor Dp-1 [ Homo sapiens (human) ]

    Gene ID: 7027, updated on 3-Dec-2024

    Summary

    Official Symbol
    TFDP1provided by HGNC
    Official Full Name
    transcription factor Dp-1provided by HGNC
    Primary source
    HGNC:HGNC:11749
    See related
    Ensembl:ENSG00000198176 MIM:189902; AllianceGenome:HGNC:11749
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DP1; DILC; Dp-1; DRTF1
    Summary
    This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
    Expression
    Ubiquitous expression in bone marrow (RPKM 54.1), lymph node (RPKM 31.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TFDP1 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113584688..113641473)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (112843768..112900540)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114239003..114295788)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5548 Neighboring gene RNA, U1 small nuclear 16, pseudogene Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114192765-114192953 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:114195260-114196459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114200259-114201002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114206049-114206550 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114236917-114237890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114237891-114238862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114240840-114241440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114251630-114252130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114268207-114268770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114267642-114268206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269335-114269898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114269899-114270462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271027-114271590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114271591-114272153 Neighboring gene uncharacterized LOC124903219 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114279174-114280373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114305936-114306560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114306561-114307185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114311832-114312332 Neighboring gene ATPase H+/K+ transporting subunit beta Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:114426222-114426826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114426827-114427432 Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114446225-114446726 Neighboring gene long intergenic non-protein coding RNA 552

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Rb-E2F complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of Rb-E2F complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor Dp-1
    Names
    DRTF1-polypeptide 1
    E2F dimerization partner 1
    E2F-related transcription factor
    down-regulated in liver cancer stem cells

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029909.1 RefSeqGene

      Range
      5066..61786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007111.5NP_009042.1  transcription factor Dp-1

      See identical proteins and their annotated locations for NP_009042.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AL442125, BC011685
      Consensus CDS
      CCDS9538.1
      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
      Related
      ENSP00000364519.4, ENST00000375370.10
      Conserved Domains (3) summary
      cd14458
      Location:198244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:113193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200338
      DP; Transcription factor DP

    RNA

    1. NR_026580.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK297114, AL442125, CD623680

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      113584688..113641473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020717.2XP_016876206.1  transcription factor Dp-1 isoform X1

    2. XM_005268327.2XP_005268384.1  transcription factor Dp-1 isoform X3

      See identical proteins and their annotated locations for XP_005268384.1

      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
      Conserved Domains (3) summary
      cd14458
      Location:198244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:113193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200338
      DP; Transcription factor DP
    3. XM_017020718.2XP_016876207.1  transcription factor Dp-1 isoform X4

      Conserved Domains (3) summary
      cd14458
      Location:198244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:113193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200338
      DP; Transcription factor DP
    4. XM_017020719.3XP_016876208.1  transcription factor Dp-1 isoform X6

      Conserved Domains (3) summary
      cd14458
      Location:198244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:113193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200335
      DP; Transcription factor DP
    5. XM_047430562.1XP_047286518.1  transcription factor Dp-1 isoform X3

      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    6. XM_047430566.1XP_047286522.1  transcription factor Dp-1 isoform X3

      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    7. XM_047430569.1XP_047286525.1  transcription factor Dp-1 isoform X4

    8. XM_047430554.1XP_047286510.1  transcription factor Dp-1 isoform X1

    9. XM_047430561.1XP_047286517.1  transcription factor Dp-1 isoform X2

    10. XM_047430570.1XP_047286526.1  transcription factor Dp-1 isoform X4

    11. XM_047430575.1XP_047286531.1  transcription factor Dp-1 isoform X6

    12. XM_047430564.1XP_047286520.1  transcription factor Dp-1 isoform X3

      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    13. XM_047430568.1XP_047286524.1  transcription factor Dp-1 isoform X4

    14. XM_047430558.1XP_047286514.1  transcription factor Dp-1 isoform X1

    15. XM_047430573.1XP_047286529.1  transcription factor Dp-1 isoform X6

    16. XM_047430560.1XP_047286516.1  transcription factor Dp-1 isoform X1

    17. XM_047430574.1XP_047286530.1  transcription factor Dp-1 isoform X6

    18. XM_005268328.3XP_005268385.1  transcription factor Dp-1 isoform X4

      See identical proteins and their annotated locations for XP_005268385.1

      Conserved Domains (3) summary
      cd14458
      Location:198244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:113193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200338
      DP; Transcription factor DP
    19. XM_047430557.1XP_047286513.1  transcription factor Dp-1 isoform X1

    20. XM_047430559.1XP_047286515.1  transcription factor Dp-1 isoform X1

    21. XM_047430563.1XP_047286519.1  transcription factor Dp-1 isoform X3

      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    22. XM_047430567.1XP_047286523.1  transcription factor Dp-1 isoform X4

    23. XM_047430572.1XP_047286528.1  transcription factor Dp-1 isoform X6

    24. XM_047430571.1XP_047286527.1  transcription factor Dp-1 isoform X5

      UniProtKB/TrEMBL
      B7Z569
    25. XM_047430576.1XP_047286532.1  transcription factor Dp-1 isoform X7

      UniProtKB/TrEMBL
      B7Z569
    26. XM_047430577.1XP_047286533.1  transcription factor Dp-1 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      112843768..112900540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374884.1XP_054230859.1  transcription factor Dp-1 isoform X1

    2. XM_054374890.1XP_054230865.1  transcription factor Dp-1 isoform X3

      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    3. XM_054374896.1XP_054230871.1  transcription factor Dp-1 isoform X4

    4. XM_054374902.1XP_054230877.1  transcription factor Dp-1 isoform X6

    5. XM_054374892.1XP_054230867.1  transcription factor Dp-1 isoform X3

      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    6. XM_054374893.1XP_054230868.1  transcription factor Dp-1 isoform X3

      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    7. XM_054374882.1XP_054230857.1  transcription factor Dp-1 isoform X1

    8. XM_054374888.1XP_054230863.1  transcription factor Dp-1 isoform X2

    9. XM_054374899.1XP_054230874.1  transcription factor Dp-1 isoform X4

    10. XM_054374905.1XP_054230880.1  transcription factor Dp-1 isoform X6

    11. XM_054374898.1XP_054230873.1  transcription factor Dp-1 isoform X4

    12. XM_054374891.1XP_054230866.1  transcription factor Dp-1 isoform X3

      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    13. XM_054374897.1XP_054230872.1  transcription factor Dp-1 isoform X4

    14. XM_054374885.1XP_054230860.1  transcription factor Dp-1 isoform X1

    15. XM_054374903.1XP_054230878.1  transcription factor Dp-1 isoform X6

    16. XM_054374887.1XP_054230862.1  transcription factor Dp-1 isoform X1

    17. XM_054374904.1XP_054230879.1  transcription factor Dp-1 isoform X6

    18. XM_054374894.1XP_054230869.1  transcription factor Dp-1 isoform X4

    19. XM_054374883.1XP_054230858.1  transcription factor Dp-1 isoform X1

    20. XM_054374886.1XP_054230861.1  transcription factor Dp-1 isoform X1

    21. XM_054374889.1XP_054230864.1  transcription factor Dp-1 isoform X3

      UniProtKB/Swiss-Prot
      B4DLQ9, Q14186, Q5JSB4, Q8IZL5
    22. XM_054374895.1XP_054230870.1  transcription factor Dp-1 isoform X4

    23. XM_054374901.1XP_054230876.1  transcription factor Dp-1 isoform X6

    24. XM_054374900.1XP_054230875.1  transcription factor Dp-1 isoform X5

      UniProtKB/TrEMBL
      B7Z569
    25. XM_054374906.1XP_054230881.1  transcription factor Dp-1 isoform X7

      UniProtKB/TrEMBL
      B7Z569
    26. XM_054374907.1XP_054230882.1  transcription factor Dp-1 isoform X8