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    TEAD3 TEA domain transcription factor 3 [ Homo sapiens (human) ]

    Gene ID: 7005, updated on 17-Jun-2024

    Summary

    Official Symbol
    TEAD3provided by HGNC
    Official Full Name
    TEA domain transcription factor 3provided by HGNC
    Primary source
    HGNC:HGNC:11716
    See related
    Ensembl:ENSG00000007866 MIM:603170; AllianceGenome:HGNC:11716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3
    Summary
    This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 22.4), endometrium (RPKM 21.2) and 23 other tissues See more
    Orthologs
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    Genomic context

    See TEAD3 in Genome Data Viewer
    Location:
    6p21.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (35473597..35497079, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (35296673..35320158, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35441374..35464856, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17092 Neighboring gene FA complementation group E Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24405 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35435944-35436500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24408 Neighboring gene ribosomal protein L10a Neighboring gene microRNA 7111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:35447729-35448229 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35453191-35453766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35454343-35454918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35456069-35456644 Neighboring gene VISTA enhancer hs1887 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35463100-35463885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35464832-35465762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:35465763-35466692 Neighboring gene uncharacterized LOC124901309 Neighboring gene TUB like protein 1 Neighboring gene MPRA-validated peak5766 silencer Neighboring gene uncharacterized LOC101929309

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in asymmetric neuroblast division IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in female pregnancy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transcriptional enhancer factor TEF-5
    Names
    TEA domain family member 3
    TEA domain family member 5
    transcriptional enhancer factor 5
    transcriptional enhancer factor TEF-5 (DTEF-1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395214.1NP_001382143.1  transcriptional enhancer factor TEF-5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL022721, AL033519
      Consensus CDS
      CCDS93900.1
      UniProtKB/TrEMBL
      A0A1X7SBS4, A0A7P0SNI2, Q71U35
      Related
      ENSP00000492431.3, ENST00000639578.3
      Conserved Domains (1) summary
      smart00426
      Location:3097
      TEA; TEA domain
    2. NM_003214.4NP_003205.2  transcriptional enhancer factor TEF-5 isoform 1

      See identical proteins and their annotated locations for NP_003205.2

      Status: REVIEWED

      Source sequence(s)
      BC027877, BC091488, DA856821
      Consensus CDS
      CCDS47414.1
      UniProtKB/Swiss-Prot
      O95910, Q5BJG7, Q8N6Y4, Q99594
      UniProtKB/TrEMBL
      A0A1X7SBS4, Q71U35
      Related
      ENSP00000345772.8, ENST00000338863.13
      Conserved Domains (1) summary
      smart00426
      Location:3097
      TEA; TEA domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      35473597..35497079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      35296673..35320158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)