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    Stat6 signal transducer and activator of transcription 6 [ Mus musculus (house mouse) ]

    Gene ID: 20852, updated on 1-Oct-2024

    Summary

    Official Symbol
    Stat6provided by MGI
    Official Full Name
    signal transducer and activator of transcription 6provided by MGI
    Primary source
    MGI:MGI:103034
    See related
    Ensembl:ENSMUSG00000002147 AllianceGenome:MGI:103034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in interleukin-4-mediated signaling pathway and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including T-helper 1 cell lineage commitment; mammary gland development; and regulation of nucleobase-containing compound metabolic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including 2-cell stage embryo; alimentary system; lower urinary tract; male reproductive system; and olfactory epithelium. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 35.4), thymus adult (RPKM 34.3) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Stat6 in Genome Data Viewer
    Location:
    10 D3; 10 74.59 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127478855..127496856)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127642955..127660987)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 1 Neighboring gene predicted gene 16217 Neighboring gene STARR-seq mESC enhancer starr_28232 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127078975-127079084 Neighboring gene predicted gene, 40802 Neighboring gene predicted gene, 30989 Neighboring gene STARR-positive B cell enhancer mm9_chr10:127099117-127099417 Neighboring gene RIKEN cDNA 1700012D01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127105871-127106058 Neighboring gene STARR-positive B cell enhancer ABC_E2971 Neighboring gene STARR-positive B cell enhancer ABC_E1133 Neighboring gene Ngfi-A binding protein 2 Neighboring gene predicted gene 16230

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IC
    Inferred by Curator
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IC
    Inferred by Curator
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within T-helper 1 cell lineage commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive nitrogen species IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to reactive nitrogen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in interleukin-4-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in interleukin-4-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-4-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of isotype switching to IgE isotypes IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mammary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of type 2 immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of isotype switching to IgE isotypes IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of mast cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase II transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal transducer and transcription activator 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009284.2NP_033310.2  signal transducer and transcription activator 6

      See identical proteins and their annotated locations for NP_033310.2

      Status: VALIDATED

      Source sequence(s)
      AK149563, AK163053, BM122652
      Consensus CDS
      CCDS36082.1
      UniProtKB/Swiss-Prot
      P52633, Q8R2F1
      UniProtKB/TrEMBL
      Q8R4D4
      Related
      ENSMUSP00000089708.6, ENSMUST00000092074.12
      Conserved Domains (5) summary
      cd10377
      Location:517646
      SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
      pfam01017
      Location:178271
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:273526
      STAT_bind; STAT protein, DNA binding domain
      pfam14596
      Location:655837
      STAT6_C; STAT6 C-terminal
      cl03749
      Location:2115
      STAT_int; STAT protein, protein interaction domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127478855..127496856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)