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    Sp3 trans-acting transcription factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 20687, updated on 12-May-2024

    Summary

    Official Symbol
    Sp3provided by MGI
    Official Full Name
    trans-acting transcription factor 3provided by MGI
    Primary source
    MGI:MGI:1277166
    See related
    Ensembl:ENSMUSG00000027109 AllianceGenome:MGI:1277166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D130027J01Rik
    Summary
    This gene product belongs to a family of Sp1 related transcription factors, which regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses transcription of numerous genes. Alternative splicing results in transcript variants encoding different isoforms, and one variant initiates translation from a non-AUG (AUA) codon. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in placenta adult (RPKM 16.1), limb E14.5 (RPKM 12.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sp3 in Genome Data Viewer
    Location:
    2 C3; 2 43.35 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (72766774..72810790, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (72936430..72980446, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6430710C18 gene Neighboring gene STARR-seq mESC enhancer starr_04823 Neighboring gene predicted gene, 39848 Neighboring gene STARR-seq mESC enhancer starr_04824 Neighboring gene predicted gene, 39849 Neighboring gene STARR-seq mESC enhancer starr_04826 Neighboring gene STARR-seq mESC enhancer starr_04827 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 5 Neighboring gene STARR-seq mESC enhancer starr_04828 Neighboring gene STARR-seq mESC enhancer starr_04829 Neighboring gene STARR-positive B cell enhancer mm9_chr2:72835176-72835477 Neighboring gene STARR-positive B cell enhancer mm9_chr2:72841087-72841388 Neighboring gene STARR-seq mESC enhancer starr_04832 Neighboring gene trans-acting transcription factor 3, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr2:72878181-72878481 Neighboring gene predicted gene, 39850 Neighboring gene STARR-seq mESC enhancer starr_04835 Neighboring gene Obg-like ATPase 1 Neighboring gene ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC105187

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within definitive hemopoiesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic camera-type eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic placenta development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic process involved in female pregnancy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within enucleate erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within liver development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lung development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within megakaryocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within monocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myeloid progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ossification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within trophectodermal cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001018042.3NP_001018052.1  transcription factor Sp3 isoform 1

      See identical proteins and their annotated locations for NP_001018052.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC079874
      Consensus CDS
      CCDS16122.1
      UniProtKB/Swiss-Prot
      A2AQK9, O70494, Q68FF2, Q8CF64, Q8K378
      UniProtKB/TrEMBL
      Q2M4I5
      Related
      ENSMUSP00000099750.4, ENSMUST00000102689.10
      Conserved Domains (4) summary
      COG5048
      Location:638720
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:625647
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:683705
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:669692
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001098425.1NP_001091895.1  transcription factor Sp3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing 2 exons from the 5' end compared to transcript variant 1, and it initiates translation from an in-frame, downstream non-AUG (AUA) codon, resulting in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BC079874, CA328978, CJ167744
      UniProtKB/TrEMBL
      Q2M4I5
      Related
      ENSMUST00000133615.2
      Conserved Domains (4) summary
      COG5048
      Location:571653
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:558580
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:616638
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:602625
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      72766774..72810790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011450.1: Suppressed sequence

      Description
      NM_011450.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.