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    Sox12 SRY (sex determining region Y)-box 12 [ Mus musculus (house mouse) ]

    Gene ID: 20667, updated on 18-Sep-2024

    Summary

    Official Symbol
    Sox12provided by MGI
    Official Full Name
    SRY (sex determining region Y)-box 12provided by MGI
    Primary source
    MGI:MGI:98360
    See related
    Ensembl:ENSMUSG00000051817 AllianceGenome:MGI:98360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010205A02Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in positive regulation of regulatory T cell differentiation; positive regulation of transcription by RNA polymerase II; and spinal cord development. Part of protein-DNA complex. Is expressed in alimentary system; brain; cranial ganglion; genitourinary system; and neural retina. Orthologous to human SOX12 (SRY-box transcription factor 12). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See Sox12 in Genome Data Viewer
    Location:
    2 G3; 2 74.94 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152235531..152239966, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152393611..152398046, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14164 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06057 Neighboring gene neurensin 2 Neighboring gene VISTA enhancer mm271 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152231818-152232119 Neighboring gene RIKEN cDNA 6820408C15 gene Neighboring gene zinc finger, CCHC domain containing 3 Neighboring gene predicted gene, 27343

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor SOX-12
    Names
    SRY-box containing gene 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011438.2NP_035568.1  transcription factor SOX-12

      See identical proteins and their annotated locations for NP_035568.1

      Status: VALIDATED

      Source sequence(s)
      AL928568, BG228657, BQ180104, CA749985, CB245116
      Consensus CDS
      CCDS38274.1
      UniProtKB/Swiss-Prot
      A2AS82, P70417, Q04890, Q6NXL2
      Related
      ENSMUSP00000138293.2, ENSMUST00000182625.2
      Conserved Domains (1) summary
      cd01388
      Location:39110
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152235531..152239966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)