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    SOX7 SRY-box transcription factor 7 [ Homo sapiens (human) ]

    Gene ID: 83595, updated on 27-Nov-2024

    Summary

    Official Symbol
    SOX7provided by HGNC
    Official Full Name
    SRY-box transcription factor 7provided by HGNC
    Primary source
    HGNC:HGNC:18196
    See related
    Ensembl:ENSG00000171056 MIM:612202; AllianceGenome:HGNC:18196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 14.9), lung (RPKM 8.3) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SOX7 in Genome Data Viewer
    Location:
    8p23.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (10723768..10730511, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (9008562..9015305)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (10581278..10588021, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10535715-10536216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10536217-10536716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10536733-10537272 Neighboring gene microRNA 4286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10537273-10537810 Neighboring gene chromosome 8 open reading frame 74 Neighboring gene RNA, 5S ribosomal pseudogene 252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10567701-10568468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10568469-10569236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18914 Neighboring gene uncharacterized LOC102723313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:10589078-10589902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10591664-10592306 Neighboring gene CRE3 CAGE-defined tissue-specific enhancer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:10616720-10616853 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:10632670-10632869 Neighboring gene PIN2 (TERF1) interacting telomerase inhibitor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:10647506-10648006 Neighboring gene microRNA 1322 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:10697101-10697601 Neighboring gene PINX1 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: PINX1

    Clone Names

    • FLJ58508, MGC10895

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor SOX-7
    Names
    SRY (sex determining region Y)-box 7
    SRY-box 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053010.1 RefSeqGene

      Range
      5064..11807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_031439.4NP_113627.1  transcription factor SOX-7

      See identical proteins and their annotated locations for NP_113627.1

      Status: REVIEWED

      Source sequence(s)
      AC105001, BC004299, HY089489
      Consensus CDS
      CCDS5977.1
      UniProtKB/Swiss-Prot
      B4DKV0, Q53YD0, Q9BT81
      UniProtKB/TrEMBL
      Q53ER5
      Related
      ENSP00000301921.1, ENST00000304501.2
      Conserved Domains (2) summary
      cd01388
      Location:44115
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam12067
      Location:198386
      Sox_C_TAD; Sox C-terminal transactivation domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      10723768..10730511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      2616667..2623410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      9008562..9015305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)