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    Nr1i3 nuclear receptor subfamily 1, group I, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 12355, updated on 12-May-2024

    Summary

    Official Symbol
    Nr1i3provided by MGI
    Official Full Name
    nuclear receptor subfamily 1, group I, member 3provided by MGI
    Primary source
    MGI:MGI:1346307
    See related
    Ensembl:ENSMUSG00000005677 AllianceGenome:MGI:1346307
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAR; MB67; Care2; ESTM32; CAR-beta
    Summary
    Enables DNA binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in cytosol and nucleus. Is expressed in genitourinary system; heart; and hemolymphoid system. Orthologous to human NR1I3 (nuclear receptor subfamily 1 group I member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 52.5), duodenum adult (RPKM 13.0) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nr1i3 in Genome Data Viewer
    Location:
    1 H3; 1 79.21 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171041503..171046414)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171213934..171218845)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2018 Neighboring gene myelin protein zero Neighboring gene Purkinje cell protein 4-like 1 Neighboring gene translocase of outer mitochondrial membrane 40-like Neighboring gene STARR-positive B cell enhancer ABC_E1573 Neighboring gene apolipoprotein A-II Neighboring gene Fc receptor, IgE, high affinity I, gamma polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC107281

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear receptor subfamily 1 group I member 3
    Names
    constitutive androstane receptor
    constitutively transactivates RAREs
    orphan nuclear receptor MB67

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243062.1NP_001229991.1  nuclear receptor subfamily 1 group I member 3 isoform 2

      See identical proteins and their annotated locations for NP_001229991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region which results in a frameshift, compared to variant 1. This results in a shorter and distinct C-terminus in isoform 2, compared to isoform 1.
      Source sequence(s)
      AI132241, AK133515
      Consensus CDS
      CCDS56654.1
      UniProtKB/Swiss-Prot
      O35627
      Related
      ENSMUSP00000074915.6, ENSMUST00000075469.12
      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116281
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. NM_001243063.1NP_001229992.1  nuclear receptor subfamily 1 group I member 3 isoform 3

      See identical proteins and their annotated locations for NP_001229992.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an in-frame alternate splice site in the 3' coding, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AI132241, AK133515, BC089541
      Consensus CDS
      CCDS56655.1
      UniProtKB/TrEMBL
      Q5FW96
      Related
      ENSMUSP00000106960.2, ENSMUST00000111328.8
      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116355
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    3. NM_009803.5NP_033933.2  nuclear receptor subfamily 1 group I member 3 isoform 1

      See identical proteins and their annotated locations for NP_033933.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC163497, AI132241, AK133515
      Consensus CDS
      CCDS15480.1
      UniProtKB/Swiss-Prot
      O35627, O35628, Q3V008
      Related
      ENSMUSP00000005820.5, ENSMUST00000005820.11
      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116356
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171041503..171046414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496628.2XP_006496691.1  nuclear receptor subfamily 1 group I member 3 isoform X1

      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116318
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    2. XM_011238743.2XP_011237045.1  nuclear receptor subfamily 1 group I member 3 isoform X2

      Conserved Domains (2) summary
      cd07156
      Location:2192
      NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
      cl11397
      Location:116281
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RNA

    1. XR_373594.4 RNA Sequence

    2. XR_373595.3 RNA Sequence