U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    NFYB nuclear transcription factor Y subunit beta [ Homo sapiens (human) ]

    Gene ID: 4801, updated on 17-Jun-2024

    Summary

    Official Symbol
    NFYBprovided by HGNC
    Official Full Name
    nuclear transcription factor Y subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:7805
    See related
    Ensembl:ENSG00000120837 MIM:189904; AllianceGenome:HGNC:7805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HAP3; CBF-A; CBF-B; NF-YB
    Summary
    The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 10.4), endometrium (RPKM 9.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NFYB in Genome Data Viewer
    Location:
    12q23.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (104117086..104138210, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (104078781..104099908, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104510864..104531988, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene phosphoglycerate mutase 1 (brain) pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23711 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4784 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:104458005-104458174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4786 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23722 Neighboring gene host cell factor C2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23731 Neighboring gene RNA, 5S ribosomal pseudogene 370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104530547-104531140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:104531141-104531732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4790 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23735 Neighboring gene uncharacterized LOC105369947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23741 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23744 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23747 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23754 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23756 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_23757 Neighboring gene long intergenic non-protein coding RNA 2385

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CCAAT-binding factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of CCAAT-binding factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear transcription factor Y subunit beta
    Names
    CAAT box DNA-binding protein subunit B
    CCAAT-binding transcription factor subunit A
    Transcription factor NF-Y, B subunit
    nuclear transcription factor Y subunit B
    nuclear transcription factor Y, beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414518.1NP_001401447.1  nuclear transcription factor Y subunit beta isoform a

      Status: REVIEWED

      Source sequence(s)
      AC089983
      UniProtKB/TrEMBL
      F8VSL3
      Related
      ENSP00000448250.2, ENST00000551446.6
    2. NM_001414519.1NP_001401448.1  nuclear transcription factor Y subunit beta isoform a

      Status: REVIEWED

      Source sequence(s)
      AC089983
      UniProtKB/TrEMBL
      F8VSL3
    3. NM_001414520.1NP_001401449.1  nuclear transcription factor Y subunit beta isoform b

      Status: REVIEWED

      Source sequence(s)
      AC089983
      UniProtKB/Swiss-Prot
      A8K7B9, P25208, Q96IY8
    4. NM_001414521.1NP_001401450.1  nuclear transcription factor Y subunit beta isoform b

      Status: REVIEWED

      Source sequence(s)
      AC089983
      UniProtKB/Swiss-Prot
      A8K7B9, P25208, Q96IY8
      Related
      ENSP00000447486.1, ENST00000551727.5
    5. NM_001414522.1NP_001401451.1  nuclear transcription factor Y subunit beta isoform c

      Status: REVIEWED

      Source sequence(s)
      AC089983
    6. NM_001414523.1NP_001401452.1  nuclear transcription factor Y subunit beta isoform d

      Status: REVIEWED

      Source sequence(s)
      AC089983
    7. NM_001414524.1NP_001401453.1  nuclear transcription factor Y subunit beta isoform d

      Status: REVIEWED

      Source sequence(s)
      AC089983
    8. NM_001414525.1NP_001401454.1  nuclear transcription factor Y subunit beta isoform d

      Status: REVIEWED

      Source sequence(s)
      AC089983
    9. NM_001414526.1NP_001401455.1  nuclear transcription factor Y subunit beta isoform d

      Status: REVIEWED

      Source sequence(s)
      AC089983
    10. NM_001414527.1NP_001401456.1  nuclear transcription factor Y subunit beta isoform e

      Status: REVIEWED

      Source sequence(s)
      AC089983
    11. NM_001414528.1NP_001401457.1  nuclear transcription factor Y subunit beta isoform f

      Status: REVIEWED

      Source sequence(s)
      AC089983
    12. NM_001414529.1NP_001401458.1  nuclear transcription factor Y subunit beta isoform f

      Status: REVIEWED

      Source sequence(s)
      AC089983
    13. NM_001414530.1NP_001401459.1  nuclear transcription factor Y subunit beta isoform g

      Status: REVIEWED

      Source sequence(s)
      AC089983
    14. NM_001414531.1NP_001401460.1  nuclear transcription factor Y subunit beta isoform h

      Status: REVIEWED

      Source sequence(s)
      AC089983
    15. NM_001414532.1NP_001401461.1  nuclear transcription factor Y subunit beta isoform h

      Status: REVIEWED

      Source sequence(s)
      AC089983
    16. NM_006166.4NP_006157.1  nuclear transcription factor Y subunit beta isoform b

      See identical proteins and their annotated locations for NP_006157.1

      Status: REVIEWED

      Source sequence(s)
      AA479300, AL042186, AU151875, AW576189, BC005316, BF032637, BG776259, BQ420877, CD678671
      Consensus CDS
      CCDS9098.1
      UniProtKB/Swiss-Prot
      A8K7B9, P25208, Q96IY8
      Related
      ENSP00000240055.3, ENST00000240055.8
      Conserved Domains (1) summary
      pfam00808
      Location:57122
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

    RNA

    1. NR_182773.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089983
    2. NR_182774.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC089983

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      104117086..104138210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268910.5XP_005268967.1  nuclear transcription factor Y subunit beta isoform X1

      See identical proteins and their annotated locations for XP_005268967.1

      UniProtKB/TrEMBL
      F8VSL3
      Conserved Domains (1) summary
      pfam00808
      Location:58123
      CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
    2. XM_047428880.1XP_047284836.1  nuclear transcription factor Y subunit beta isoform X2

      UniProtKB/Swiss-Prot
      A8K7B9, P25208, Q96IY8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      104078781..104099908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372113.1XP_054228088.1  nuclear transcription factor Y subunit beta isoform X1

      UniProtKB/TrEMBL
      F8VSL3
    2. XM_054372114.1XP_054228089.1  nuclear transcription factor Y subunit beta isoform X2

      UniProtKB/Swiss-Prot
      A8K7B9, P25208, Q96IY8