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    Myog myogenin [ Mus musculus (house mouse) ]

    Gene ID: 17928, updated on 2-Nov-2024

    Summary

    Official Symbol
    Myogprovided by MGI
    Official Full Name
    myogeninprovided by MGI
    Primary source
    MGI:MGI:97276
    See related
    Ensembl:ENSMUSG00000026459 AllianceGenome:MGI:97276
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    myo; MYF4; bHLHc3
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and chromatin DNA binding activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of cell differentiation; and regulation of muscle adaptation. Acts upstream of or within several processes, including cellular response to lithium ion; cellular response to tumor necrosis factor; and skeletal muscle fiber development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and musculature. Orthologous to human MYOG (myogenin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 55.9), CNS E11.5 (RPKM 6.5) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Myog in Genome Data Viewer
    Location:
    1 E4; 1 58.18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134217742..134220286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134290004..134292548)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32221 Neighboring gene STARR-seq mESC enhancer starr_02321 Neighboring gene predicted gene, 24517 Neighboring gene myogenin promoter-associated myogenic regulatory antisense lncRNA Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 Neighboring gene predicted gene, 32267 Neighboring gene transmembrane protein 183A Neighboring gene STARR-seq mESC enhancer starr_02324

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IC
    Inferred by Curator
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific TAS
    Traceable Author Statement
    more info
    PubMed 
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lithium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within muscle organ development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within myotube differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of muscle atrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myoblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of myotube differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of oxidative phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of skeletal muscle fiber development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of skeletal muscle satellite cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to denervation involved in regulation of muscle adaptation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to electrical stimulus involved in regulation of muscle adaptation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to electrical stimulus involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to muscle activity involved in regulation of muscle adaptation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to muscle activity involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in skeletal muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in striated muscle atrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-DNA complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    myogenin
    Names
    MYOD1-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031189.2NP_112466.1  myogenin

      See identical proteins and their annotated locations for NP_112466.1

      Status: VALIDATED

      Source sequence(s)
      BC048683, CJ096370
      Consensus CDS
      CCDS15306.1
      UniProtKB/Swiss-Prot
      P12979
      Related
      ENSMUSP00000027730.5, ENSMUST00000027730.6
      Conserved Domains (2) summary
      smart00520
      Location:186
      BASIC; Basic domain in HLH proteins of MYOD family
      pfam00010
      Location:82133
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      134217742..134220286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)