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MTA3 metastasis associated 1 family member 3 [ Homo sapiens (human) ]

Gene ID: 57504, updated on 18-Sep-2024

Summary

Official Symbol
MTA3provided by HGNC
Official Full Name
metastasis associated 1 family member 3provided by HGNC
Primary source
HGNC:HGNC:23784
See related
Ensembl:ENSG00000057935 MIM:609050; AllianceGenome:HGNC:23784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 6.3), ovary (RPKM 5.7) and 24 other tissues See more
Orthologs
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Genomic context

See MTA3 in Genome Data Viewer
Location:
2p21
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (42494110..42756946)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (42499549..42762201)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (42721250..42984086)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel modifier subfamily G member 3 Neighboring gene voltage dependent anion channel 1 pseudogene 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42719309-42720066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42720067-42720824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11406 Neighboring gene Sharpr-MPRA regulatory region 13941 Neighboring gene ribosomal protein S13 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42752168-42752668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42752669-42753169 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:42772737-42773623 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42774519-42775024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15649 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11407 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42798824-42799350 Neighboring gene uncharacterized LOC105374555 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:42833249-42834000 Neighboring gene MPRA-validated peak3682 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr2:42881137-42881638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15651 Neighboring gene Sharpr-MPRA regulatory region 10188 Neighboring gene RNA, U6 small nuclear 137, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:42983184-42983754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:42983755-42984326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:42994558-42995463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11411 Neighboring gene oxoeicosanoid receptor 1 Neighboring gene 3-hydroxyanthranilate 3,4-dioxygenase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1266

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NuRD complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
metastasis-associated protein MTA3
Names
metastasis associated gene family, member 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282755.2NP_001269684.1  metastasis-associated protein MTA3 isoform a

    See identical proteins and their annotated locations for NP_001269684.1

    Status: VALIDATED

    Source sequence(s)
    AB033092, AC025750, AK127245, AW292870, DA239202
    Consensus CDS
    CCDS62900.1
    UniProtKB/TrEMBL
    E7EV10, F6RRE2
    Related
    ENSP00000383973.1, ENST00000405592.5
    Conserved Domains (5) summary
    cd11661
    Location:214259
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:319368
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam01448
    Location:94145
    ELM2; ELM2 domain
    pfam17226
    Location:404480
    MTA_R1; MTA R1 domain
    cl02608
    Location:2114
    BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
  2. NM_001282756.2NP_001269685.1  metastasis-associated protein MTA3 isoform a

    See identical proteins and their annotated locations for NP_001269685.1

    Status: VALIDATED

    Source sequence(s)
    AB033092, AW292870
    Consensus CDS
    CCDS62900.1
    UniProtKB/TrEMBL
    E7EV10, F6RRE2
    Related
    ENSP00000384249.1, ENST00000406652.5
    Conserved Domains (5) summary
    cd11661
    Location:214259
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:319368
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    pfam01448
    Location:94145
    ELM2; ELM2 domain
    pfam17226
    Location:404480
    MTA_R1; MTA R1 domain
    cl02608
    Location:2114
    BAH; or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in ...
  3. NM_001330442.2NP_001317371.1  metastasis-associated protein MTA3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (c).
    Source sequence(s)
    AC025750, AC074375, AC098824
    Consensus CDS
    CCDS82441.1
    UniProtKB/Swiss-Prot
    Q9BTC8, Q9NSP2, Q9ULF4
    UniProtKB/TrEMBL
    E7EV10
    Related
    ENSP00000385823.1, ENST00000405094.2
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:376425
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:461537
    MTA_R1; MTA R1 domain
  4. NM_001330443.2NP_001317372.1  metastasis-associated protein MTA3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC025750, AC074375, AC098824
    UniProtKB/TrEMBL
    E7EV10
    Related
    ENSP00000386763.1, ENST00000409019.5
    Conserved Domains (5) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:375424
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:460536
    MTA_R1; MTA R1 domain
  5. NM_001330444.2NP_001317373.1  metastasis-associated protein MTA3 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC025750, AC074375, AC098824
    UniProtKB/TrEMBL
    E7EV10
    Conserved Domains (5) summary
    smart00401
    Location:312361
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain
    pfam17226
    Location:397473
    MTA_R1; MTA R1 domain
    cl21498
    Location:234252
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  6. NM_020744.4NP_065795.1  metastasis-associated protein MTA3 isoform b

    See identical proteins and their annotated locations for NP_065795.1

    Status: VALIDATED

    Source sequence(s)
    BC053631, CA447673, DB335600
    Consensus CDS
    CCDS46267.1
    UniProtKB/TrEMBL
    E7EV10
    Related
    ENSP00000385045.3, ENST00000407270.7
    Conserved Domains (4) summary
    cd11661
    Location:270315
    SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
    smart00401
    Location:376425
    ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
    cd04709
    Location:3170
    BAH_MTA; BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH ...
    pfam01448
    Location:150201
    ELM2; ELM2 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    42494110..42756946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    42499549..42762201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)