U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Klf1 Kruppel-like transcription factor 1 (erythroid) [ Mus musculus (house mouse) ]

    Gene ID: 16596, updated on 27-Nov-2024

    Summary

    Official Symbol
    Klf1provided by MGI
    Official Full Name
    Kruppel-like transcription factor 1 (erythroid)provided by MGI
    Primary source
    MGI:MGI:1342771
    See related
    Ensembl:ENSMUSG00000054191 AllianceGenome:MGI:1342771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nan; Eklf
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in erythrocyte differentiation; positive regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hemopoiesis; in utero embryonic development; and liver development. Predicted to be located in chromatin and nucleoplasm. Is expressed in several structures, including extraembryonic component; hemolymphoid system; olfactory placode; testis; and urethra. Used to study beta thalassemia and hereditary spherocytosis. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (KLF transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14.5 (RPKM 150.9), liver E14 (RPKM 122.7) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Klf1 in Genome Data Viewer
    Location:
    8 41.3 cM; 8 C3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85628611..85631920)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84901982..84905291)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11391 Neighboring gene synaptonemal complex central element protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E1763 Neighboring gene glutaryl-Coenzyme A dehydrogenase Neighboring gene predicted gene, 39213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87427053-87427162 Neighboring gene STARR-positive B cell enhancer ABC_E1373 Neighboring gene deoxyribonuclease II alpha Neighboring gene predicted gene, 38426 Neighboring gene microtubule associated serine/threonine kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within erythrocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    Krueppel-like factor 1
    Names
    Kruppel-like factor 1 (erythroid)
    erythroid krueppel-like transcription factor
    erythroid transcription factor
    neonatal anemia

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010635.3NP_034765.3  Krueppel-like factor 1

      Status: VALIDATED

      Source sequence(s)
      AC161765
      Consensus CDS
      CCDS22483.1
      UniProtKB/Swiss-Prot
      O70261, P46099
      UniProtKB/TrEMBL
      E9QNP6
      Related
      ENSMUSP00000064366.9, ENSMUST00000067060.10
      Conserved Domains (4) summary
      COG5048
      Location:279357
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280299
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16832
      Location:2239
      EKLF_TAD1; Erythroid krueppel-like transcription factor, transactivation 1
      pfam16833
      Location:6385
      EKLF_TAD2; Erythroid krueppel-like transcription factor, transactivation 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85628611..85631920
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)