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    Irf7 interferon regulatory factor 7 [ Mus musculus (house mouse) ]

    Gene ID: 54123, updated on 2-Nov-2024

    Summary

    Official Symbol
    Irf7provided by MGI
    Official Full Name
    interferon regulatory factor 7provided by MGI
    Primary source
    MGI:MGI:1859212
    See related
    Ensembl:ENSMUSG00000025498 AllianceGenome:MGI:1859212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to symbiont; positive regulation of macromolecule biosynthetic process; and regulation of toll-like receptor signaling pathway. Acts upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon-mediated signaling pathway; and regulation of gene expression. Predicted to be located in chromatin; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in apical ectodermal ridge; central nervous system; embryo; liver; and ureter. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in duodenum adult (RPKM 108.3), small intestine adult (RPKM 93.2) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Irf7 in Genome Data Viewer
    Location:
    7 F5; 7 86.57 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140843096..140846412, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141263183..141266499, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2854 Neighboring gene microRNA 210 Neighboring gene STARR-positive B cell enhancer ABC_E11376 Neighboring gene predicted gene, 51460 Neighboring gene PHD and ring finger domains 1 Neighboring gene cadherin-related family member 5 Neighboring gene secretin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cytoplasmic pattern recognition receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type I interferon production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of MyD88-dependent toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of MyD88-independent toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within type I interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interferon regulatory factor 7
    Names
    IRF-7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252600.1NP_001239529.1  interferon regulatory factor 7 isoform 2

      See identical proteins and their annotated locations for NP_001239529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK152403, BQ033099, BY155234
      Consensus CDS
      CCDS57595.1
      UniProtKB/TrEMBL
      Q3TW14
      Related
      ENSMUSP00000095565.3, ENSMUST00000097952.9
      Conserved Domains (2) summary
      pfam00605
      Location:11124
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:212389
      IRF-3; Interferon-regulatory factor 3
    2. NM_001252601.1NP_001239530.1  interferon regulatory factor 7 isoform 3

      See identical proteins and their annotated locations for NP_001239530.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK002830, AK151470, BQ033099, BY155234, DT923384
      Consensus CDS
      CCDS57594.1
      UniProtKB/TrEMBL
      D3Z4U9
      Related
      ENSMUSP00000101644.2, ENSMUST00000106023.8
      Conserved Domains (2) summary
      pfam00605
      Location:11124
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:211388
      IRF-3; Interferon-regulatory factor 3
    3. NM_016850.3NP_058546.1  interferon regulatory factor 7 isoform 1

      See identical proteins and their annotated locations for NP_058546.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AK079685, BQ033099, BY155234
      Consensus CDS
      CCDS22005.1
      UniProtKB/Swiss-Prot
      P70434
      UniProtKB/TrEMBL
      Q542T3
      Related
      ENSMUSP00000026571.5, ENSMUST00000026571.11
      Conserved Domains (2) summary
      pfam00605
      Location:11124
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:243420
      IRF-3; Interferon-regulatory factor 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140843096..140846412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536214.1XP_006536277.1  interferon regulatory factor 7 isoform X1

      Conserved Domains (2) summary
      pfam00605
      Location:12124
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:180357
      IRF-3; Interferon-regulatory factor 3