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    Hoxb8 homeobox B8 [ Mus musculus (house mouse) ]

    Gene ID: 15416, updated on 12-May-2024

    Summary

    Official Symbol
    Hoxb8provided by MGI
    Official Full Name
    homeobox B8provided by MGI
    Primary source
    MGI:MGI:96189
    See related
    Ensembl:ENSMUSG00000056648 AllianceGenome:MGI:96189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hox-2.4
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of myeloid cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including dorsal spinal cord development; embryonic skeletal system morphogenesis; and grooming behavior. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; extraembryonic component; genitourinary system; nervous system; and neural ectoderm. Used to study trichotillomania. Orthologous to human HOXB8 (homeobox B8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in adrenal adult (RPKM 49.5), genital fat pad adult (RPKM 24.0) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hoxb8 in Genome Data Viewer
    Location:
    11 D; 11 59.82 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96170227..96176151)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96279401..96285325)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 196a-1 Neighboring gene predicted gene, 51876 Neighboring gene homeobox B9 Neighboring gene homeobox B7 Neighboring gene STARR-seq mESC enhancer starr_30545 Neighboring gene homeobox B5 and homeobox B6, opposite strand Neighboring gene homeobox B6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dorsal spinal cord development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within grooming behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    homeobox protein Hox-B8
    Names
    homeo box B8
    homeobox protein Hox-2.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010461.2NP_034591.1  homeobox protein Hox-B8

      See identical proteins and their annotated locations for NP_034591.1

      Status: VALIDATED

      Source sequence(s)
      AK083980, AK131612, AL645478
      Consensus CDS
      CCDS25293.1
      UniProtKB/Swiss-Prot
      P09632
      UniProtKB/TrEMBL
      A2A9Z8
      Related
      ENSMUSP00000052496.3, ENSMUST00000052650.4
      Conserved Domains (1) summary
      pfam00046
      Location:150203
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96170227..96176151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314295.2XP_017169784.1  homeobox protein Hox-B8 isoform X1

      UniProtKB/Swiss-Prot
      P09632
      UniProtKB/TrEMBL
      A2A9Z8
      Conserved Domains (1) summary
      pfam00046
      Location:150203
      Homeobox; Homeobox domain
    2. XM_011248758.3XP_011247060.1  homeobox protein Hox-B8 isoform X2

      See identical proteins and their annotated locations for XP_011247060.1

      Conserved Domains (1) summary
      pfam00046
      Location:149202
      Homeobox; Homeobox domain
    3. XM_017314296.2XP_017169785.1  homeobox protein Hox-B8 isoform X1

      UniProtKB/Swiss-Prot
      P09632
      UniProtKB/TrEMBL
      A2A9Z8
      Conserved Domains (1) summary
      pfam00046
      Location:150203
      Homeobox; Homeobox domain
    4. XM_017314297.2XP_017169786.1  homeobox protein Hox-B8 isoform X1

      UniProtKB/Swiss-Prot
      P09632
      UniProtKB/TrEMBL
      A2A9Z8
      Conserved Domains (1) summary
      pfam00046
      Location:150203
      Homeobox; Homeobox domain