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    Hoxb13 homeobox B13 [ Mus musculus (house mouse) ]

    Gene ID: 15408, updated on 18-Sep-2024

    Summary

    Official Symbol
    Hoxb13provided by MGI
    Official Full Name
    homeobox B13provided by MGI
    Primary source
    MGI:MGI:107730
    See related
    Ensembl:ENSMUSG00000049604 AllianceGenome:MGI:107730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Acts upstream of or within epithelial cell maturation involved in prostate gland development; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; and regulation of growth. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; lung; spinal cord; and tail. Human ortholog(s) of this gene implicated in ductal carcinoma in situ and renal cell carcinoma. Orthologous to human HOXB13 (homeobox B13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward colon adult (RPKM 258.3) See more
    Orthologs
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    Genomic context

    See Hoxb13 in Genome Data Viewer
    Location:
    11 D; 11 59.63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96085142..96087436)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96194316..96196610)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene calcium binding and coiled-coil domain 2 Neighboring gene STARR-seq mESC enhancer starr_30533 Neighboring gene STARR-positive B cell enhancer mm9_chr11:95988247-95988548 Neighboring gene STARR-seq mESC enhancer starr_30537 Neighboring gene STARR-seq mESC enhancer starr_30538 Neighboring gene STARR-seq mESC enhancer starr_30539 Neighboring gene tubulin tyrosine ligase-like family, member 6 Neighboring gene predicted gene, 30084 Neighboring gene STARR-seq mESC enhancer starr_30541 Neighboring gene STARR-seq mESC enhancer starr_30542 Neighboring gene predicted gene, 30134 Neighboring gene predicted gene 11538 Neighboring gene ribosomal protein L18 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein Hox-B13
    Names
    homeo box B13

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008267.4NP_032293.1  homeobox protein Hox-B13

      See identical proteins and their annotated locations for NP_032293.1

      Status: VALIDATED

      Source sequence(s)
      AL645478
      Consensus CDS
      CCDS25291.1
      UniProtKB/Swiss-Prot
      P70321, Q80Y12
      Related
      ENSMUSP00000056315.4, ENSMUST00000062709.4
      Conserved Domains (2) summary
      smart00389
      Location:218274
      HOX; Homeodomain
      pfam12284
      Location:12122
      HoxA13_N; Hox protein A13 N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96085142..96087436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)