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FOXO6 forkhead box O6 [ Homo sapiens (human) ]

Gene ID: 100132074, updated on 27-Nov-2024

Summary

Official Symbol
FOXO6provided by HGNC
Official Full Name
forkhead box O6provided by HGNC
Primary source
HGNC:HGNC:24814
See related
Ensembl:ENSG00000204060 MIM:611457; AllianceGenome:HGNC:24814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of dendritic spine development and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: suggests misassembly
Expression
Broad expression in brain (RPKM 1.8), ovary (RPKM 1.5) and 21 other tissues See more
Orthologs
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Genomic context

See FOXO6 in Genome Data Viewer
Location:
1p34.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (41361434..41383590)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (41230844..41253232)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41827106..41849262)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 861 Neighboring gene uncharacterized LOC124904159 Neighboring gene Sharpr-MPRA regulatory region 968 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_8062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 863 Neighboring gene Sharpr-MPRA regulatory region 246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41836248-41837147 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41837148-41838046 Neighboring gene FOXO6 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 747 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41852742-41853722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41860605-41861174 Neighboring gene Sharpr-MPRA regulatory region 9429 Neighboring gene Sharpr-MPRA regulatory region 3622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41889556-41890113 Neighboring gene uncharacterized LOC105378678 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:41893573-41893763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 865 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41899108-41899739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:41899838-41900622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:41916745-41917304 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:41928734-41929234 Neighboring gene RNA, 5S ribosomal pseudogene 45

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291281.3NP_001278210.2  forkhead box protein O6

    Status: VALIDATED

    Source sequence(s)
    FO681542
    UniProtKB/Swiss-Prot
    A8MYZ6
    UniProtKB/TrEMBL
    A0A1X9RU27
    Related
    ENST00000372591.1
    Conserved Domains (3) summary
    cd00059
    Location:88168
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
    pfam16675
    Location:358382
    FOXO_KIX_bdg; KIX-binding domain of forkhead box O, CR2
    pfam16676
    Location:499537
    FOXO-TAD; Transactivation domain of FOXO protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    41361434..41383590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646194.1 Reference GRCh38.p14 PATCHES

    Range
    111107..133486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    41230844..41253232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)