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FEV FEV transcription factor, ETS family member [ Homo sapiens (human) ]

Gene ID: 54738, updated on 2-Nov-2024

Summary

Official Symbol
FEVprovided by HGNC
Official Full Name
FEV transcription factor, ETS family memberprovided by HGNC
Primary source
HGNC:HGNC:18562
See related
Ensembl:ENSG00000163497 MIM:607150; AllianceGenome:HGNC:18562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PET-1; HSRNAFEV
Summary
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 1.5), stomach (RPKM 1.5) and 5 other tissues See more
Orthologs
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Genomic context

See FEV in Genome Data Viewer
Location:
2q35
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218981087..218985184, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219469462..219473559, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219845809..219849906, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12338 Neighboring gene cyclin dependent kinase 5 regulatory subunit 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:219828036-219829235 Neighboring gene long intergenic non-protein coding RNA 608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17137 Neighboring gene crystallin beta A2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:219864283-219865266 Neighboring gene microRNA 375

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of antibody response to smallpox vaccine.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in maternal behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein FEV
Names
FEV (ETS oncogene family)
FEV, ETS transcription factor
PC12 ETS domain-containing transcription factor 1
fifth Ewing variant protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023323.1 RefSeqGene

    Range
    5474..9571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017521.3NP_059991.1  protein FEV

    See identical proteins and their annotated locations for NP_059991.1

    Status: REVIEWED

    Source sequence(s)
    AC097468
    Consensus CDS
    CCDS2428.1
    UniProtKB/Swiss-Prot
    Q99581
    Related
    ENSP00000295727.1, ENST00000295727.2
    Conserved Domains (1) summary
    smart00413
    Location:46131
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    218981087..218985184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444822.1XP_047300778.1  protein FEV isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219469462..219473559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342655.1XP_054198630.1  protein FEV isoform X1