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    Etv4 ets variant 4 [ Mus musculus (house mouse) ]

    Gene ID: 18612, updated on 18-Sep-2024

    Summary

    Official Symbol
    Etv4provided by MGI
    Official Full Name
    ets variant 4provided by MGI
    Primary source
    MGI:MGI:99423
    See related
    Ensembl:ENSMUSG00000017724 AllianceGenome:MGI:99423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pea3; Pea-3
    Summary
    Enables DNA binding activity. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including branching involved in mammary gland duct morphogenesis; motor neuron axon guidance; and negative regulation of mammary gland epithelial cell proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; sensory organ; and urinary system. Orthologous to human ETV4 (ETS variant transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 15.6), colon adult (RPKM 7.7) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Etv4 in Genome Data Viewer
    Location:
    11 D; 11 65.48 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101660573..101677963, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101769747..101785310, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39391 Neighboring gene STARR-positive B cell enhancer ABC_E3025 Neighboring gene DEAH-box helicase 8 Neighboring gene STARR-seq mESC enhancer starr_30780 Neighboring gene STARR-positive B cell enhancer ABC_E2371 Neighboring gene STARR-seq mESC enhancer starr_30781 Neighboring gene predicted gene, 39392 Neighboring gene STARR-positive B cell enhancer mm9_chr11:101674595-101674896 Neighboring gene STARR-seq mESC enhancer starr_30783 Neighboring gene mesenchyme homeobox 1 Neighboring gene STARR-seq mESC enhancer starr_30784 Neighboring gene predicted gene, 33662

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS translocation variant 4
    Names
    ETS variant protein 4
    POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4)
    ets variant gene 4 (E1A enhancer binding protein, E1AF)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316365.1NP_001303294.1  ETS translocation variant 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK144538, AL591436, BY733846, DQ832277
      Consensus CDS
      CCDS83903.1
      UniProtKB/TrEMBL
      A2A5C3, A6MDC6
      Related
      ENSMUSP00000017868.7, ENSMUST00000017868.7
      Conserved Domains (2) summary
      smart00413
      Location:343426
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:7341
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    2. NM_001316366.1NP_001303295.1  ETS translocation variant 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK144538, AL591436, DQ832277
      Consensus CDS
      CCDS83902.1
      UniProtKB/TrEMBL
      A2A5C2, A6MDC6
      Related
      ENSMUSP00000102794.2, ENSMUST00000107176.8
      Conserved Domains (2) summary
      smart00413
      Location:337420
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:7335
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    3. NM_008815.3NP_032841.2  ETS translocation variant 4 isoform 2

      See identical proteins and their annotated locations for NP_032841.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK144538, AL591436, DQ832277
      Consensus CDS
      CCDS48937.1
      UniProtKB/Swiss-Prot
      P28322, Q3UMZ6
      UniProtKB/TrEMBL
      A6MDC6
      Related
      ENSMUSP00000129261.2, ENSMUST00000164750.8
      Conserved Domains (2) summary
      smart00413
      Location:342425
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:7340
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101660573..101677963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245656.2XP_030101516.1  ETS translocation variant 4 isoform X7

      UniProtKB/TrEMBL
      A6MDC6
      Conserved Domains (2) summary
      smart00413
      Location:338421
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:8336
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    2. XM_006532462.5XP_006532525.1  ETS translocation variant 4 isoform X5

      UniProtKB/TrEMBL
      A6MDC6
      Conserved Domains (2) summary
      smart00413
      Location:344427
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:8342
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    3. XM_006532461.4XP_006532524.1  ETS translocation variant 4 isoform X4

      UniProtKB/TrEMBL
      A6MDC6
      Conserved Domains (2) summary
      smart00413
      Location:383466
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:54381
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    4. XM_006532459.4XP_006532522.1  ETS translocation variant 4 isoform X2

      UniProtKB/TrEMBL
      A6MDC6
      Conserved Domains (2) summary
      smart00413
      Location:389472
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:54387
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    5. XM_006532460.4XP_006532523.1  ETS translocation variant 4 isoform X3

      UniProtKB/TrEMBL
      A6MDC6
      Conserved Domains (2) summary
      smart00413
      Location:384467
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:54382
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    6. XM_006532458.4XP_006532521.1  ETS translocation variant 4 isoform X1

      UniProtKB/TrEMBL
      A6MDC6
      Conserved Domains (2) summary
      smart00413
      Location:390473
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:54388
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    7. XM_036156416.1XP_036012309.1  ETS translocation variant 4 isoform X6

      UniProtKB/TrEMBL
      A2A5C3, A6MDC6
      Conserved Domains (2) summary
      smart00413
      Location:343426
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:7341
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    8. XM_036156418.1XP_036012311.1  ETS translocation variant 4 isoform X8

      UniProtKB/TrEMBL
      A2A5C2, A6MDC6
      Conserved Domains (2) summary
      smart00413
      Location:337420
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:7335
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    9. XM_036156419.1XP_036012312.1  ETS translocation variant 4 isoform X8

      UniProtKB/TrEMBL
      A2A5C2, A6MDC6
      Conserved Domains (2) summary
      smart00413
      Location:337420
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:7335
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    10. XM_036156417.1XP_036012310.1  ETS translocation variant 4 isoform X6

      UniProtKB/TrEMBL
      A2A5C3, A6MDC6
      Conserved Domains (2) summary
      smart00413
      Location:343426
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:7341
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain