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    Etv2 ets variant 2 [ Mus musculus (house mouse) ]

    Gene ID: 14008, updated on 2-Nov-2024

    Summary

    Official Symbol
    Etv2provided by MGI
    Official Full Name
    ets variant 2provided by MGI
    Primary source
    MGI:MGI:99253
    See related
    Ensembl:ENSMUSG00000006311 AllianceGenome:MGI:99253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Etsrp71
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of endothelial cell differentiation; and positive regulation of mesoderm development. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and hemolymphoid system. Human ortholog(s) of this gene implicated in limb ischemia. Orthologous to human ETV2 (ETS variant transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 3.1) See more
    Orthologs
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    Genomic context

    See Etv2 in Genome Data Viewer
    Location:
    7 B1; 7 18.92 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30333041..30335934, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30633616..30636509, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18526 Neighboring gene uroplakin 1A Neighboring gene cytochrome c oxidase, subunit 6B1 Neighboring gene STARR-positive B cell enhancer ABC_E2232 Neighboring gene STARR-seq mESC enhancer starr_18529 Neighboring gene RNA binding motif protein 42 Neighboring gene STARR-positive B cell enhancer ABC_E545 Neighboring gene STARR-seq mESC enhancer starr_18530 Neighboring gene HAUS augmin-like complex, subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E6533

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within blastocyst development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mesoderm formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of endothelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mesoderm development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ETS translocation variant 2
    Names
    ets variant gene 2
    ets-related protein 71

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007959.2NP_031985.2  ETS translocation variant 2

      See identical proteins and their annotated locations for NP_031985.2

      Status: VALIDATED

      Source sequence(s)
      AB221612, BX638426, L10427
      Consensus CDS
      CCDS39888.1
      UniProtKB/Swiss-Prot
      F8VQ08, P41163
      Related
      ENSMUSP00000103782.3, ENSMUST00000108147.3
      Conserved Domains (1) summary
      smart00413
      Location:233315
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30333041..30335934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539542.2XP_006539605.1  ETS translocation variant 2 isoform X2

      Conserved Domains (1) summary
      smart00413
      Location:255337
      ETS; erythroblast transformation specific domain
    2. XM_006539541.2XP_006539604.1  ETS translocation variant 2 isoform X1

      See identical proteins and their annotated locations for XP_006539604.1

      UniProtKB/TrEMBL
      Q5EP41
      Conserved Domains (1) summary
      smart00413
      Location:256338
      ETS; erythroblast transformation specific domain