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    ELF3 E74 like ETS transcription factor 3 [ Homo sapiens (human) ]

    Gene ID: 1999, updated on 17-Jun-2024

    Summary

    Official Symbol
    ELF3provided by HGNC
    Official Full Name
    E74 like ETS transcription factor 3provided by HGNC
    Primary source
    HGNC:HGNC:3318
    See related
    Ensembl:ENSG00000163435 MIM:602191; AllianceGenome:HGNC:3318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERT; ESX; EPR-1; ESE-1
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in inflammatory response; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon (RPKM 88.6), stomach (RPKM 68.2) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ELF3 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (202010587..202017183)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (201268232..201274828)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (201979715..201986311)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1696 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:201955078-201955252 Neighboring gene ribosomal protein L10 pseudogene 4 Neighboring gene VISTA enhancer hs2572 Neighboring gene arginyl aminopeptidase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201973460-201974102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201977313-201977954 Neighboring gene ELF3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201979681-201980614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201980615-201981549 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:201982359-201983558 Neighboring gene microRNA 6740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:201987061-201987829 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:202038709-202039458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202041245-202041744 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:202053789-202054548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:202054549-202055308 Neighboring gene FOXA motif-containing MPRA enhancer 200 Neighboring gene uncharacterized LOC105371684 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:202072166-202073140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:202073141-202074115 Neighboring gene cysteine rich protein 1 pseudogene 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:202077042-202078015 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10703 Neighboring gene uncharacterized LOC105371683 Neighboring gene G protein-coupled receptor 37 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of E74-like factor 3 (ets domain transcription factor, epithelial-specific; ELF3) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of E74-like factor 3 (ELF3) expression as compared to untreated control PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in blastocyst development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in mammary gland involution ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS-related transcription factor Elf-3
    Names
    E74-like factor 3 (ETS domain transcription factor, serine box, epithelial-specific)
    E74-like factor 3 (ets domain transcription factor)
    E74-like factor 3 (ets domain transcription factor, epithelial-specific )
    epithelial-restricted with serine box
    epithelium-restricted Ets protein ESX
    epithelium-specific Ets transcription factor 1
    ets domain transcription factor, serine box (epithelial-specific)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114309.2NP_001107781.1  ETS-related transcription factor Elf-3

      See identical proteins and their annotated locations for NP_001107781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC003569, BM976796, BQ023145, BX093212, CV570925, CV570991, DA591406
      Consensus CDS
      CCDS1419.1
      UniProtKB/Swiss-Prot
      B2R5Q6, P78545, Q6IAP8, Q7RU03, Q7Z3X2, Q8NFG2, Q99718
      UniProtKB/TrEMBL
      A0A8E8R9T1
      Related
      ENSP00000356252.3, ENST00000367283.7
      Conserved Domains (2) summary
      cd08537
      Location:53132
      SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
      smart00413
      Location:272359
      ETS; erythroblast transformation specific domain
    2. NM_004433.5NP_004424.3  ETS-related transcription factor Elf-3

      See identical proteins and their annotated locations for NP_004424.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the shorter transcript (1). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC003569, BM976796, BQ023145, BX093212, CV570925, CV570991
      Consensus CDS
      CCDS1419.1
      UniProtKB/Swiss-Prot
      B2R5Q6, P78545, Q6IAP8, Q7RU03, Q7Z3X2, Q8NFG2, Q99718
      UniProtKB/TrEMBL
      A0A8E8R9T1
      Related
      ENSP00000356253.5, ENST00000367284.10
      Conserved Domains (2) summary
      cd08537
      Location:53132
      SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
      smart00413
      Location:272359
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      202010587..202017183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005244942.4XP_005244999.1  ETS-related transcription factor Elf-3 isoform X1

      UniProtKB/TrEMBL
      Q5SR36
      Conserved Domains (1) summary
      cd08537
      Location:53132
      SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      201268232..201274828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334877.1XP_054190852.1  ETS-related transcription factor Elf-3 isoform X1

      UniProtKB/TrEMBL
      Q5SR36