U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Bcl11a BCL11 transcription factor A [ Mus musculus (house mouse) ]

    Gene ID: 14025, updated on 24-Sep-2024

    Summary

    Official Symbol
    Bcl11aprovided by MGI
    Official Full Name
    BCL11 transcription factor Aprovided by MGI
    Primary source
    MGI:MGI:106190
    See related
    Ensembl:ENSMUSG00000000861 AllianceGenome:MGI:106190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Evi9; Ctip1; Evi9a; Evi9b; Evi9c; BCL-11A; mKIAA1809; 2810047E18Rik; D930021L15Rik
    Summary
    Enables transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and protein sumoylation. Acts upstream of or within B cell differentiation; T cell differentiation; and negative regulation of gene expression. Located in nuclear body. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autism spectrum disorder; beta thalassemia; schizophrenia; and sickle cell anemia. Orthologous to human BCL11A (BAF chromatin remodeling complex subunit BCL11A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E14 (RPKM 11.6), CNS E18 (RPKM 11.0) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bcl11a in Genome Data Viewer
    Location:
    11 A3.2; 11 14.41 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (24026498..24123558)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (24076564..24173558)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene poly(A) polymerase gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:23795118-23795419 Neighboring gene STARR-seq mESC enhancer starr_28926 Neighboring gene predicted gene 12061 Neighboring gene STARR-seq mESC enhancer starr_28927 Neighboring gene STARR-seq mESC enhancer starr_28928 Neighboring gene RIKEN cDNA A830031A19 gene Neighboring gene STARR-positive B cell enhancer mm9_chr11:23949249-23949549 Neighboring gene predicted gene, 57804 Neighboring gene STARR-positive B cell enhancer mm9_chr11:23977830-23978131 Neighboring gene STARR-seq mESC enhancer starr_28930 Neighboring gene STARR-seq mESC enhancer starr_28931 Neighboring gene STARR-positive B cell enhancer ABC_E9360 Neighboring gene RIKEN cDNA 4930538E20 gene Neighboring gene STARR-positive B cell enhancer ABC_E5212 Neighboring gene STARR-seq mESC enhancer starr_28933 Neighboring gene predicted gene 12066 Neighboring gene predicted gene, 33440 Neighboring gene predicted gene, 33379

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of branching morphogenesis of a nerve ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in paraspeckles ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    B-cell lymphoma/leukemia 11A
    Names
    B cell CLL/lymphoma 11A (zinc finger protein)
    B-cell CLL/lymphoma 11A
    COUP-TF interacting protein 1
    EVI-9
    ecotropic viral integration site 9 protein
    myeloid leukemia

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159289.1NP_001152761.1  B-cell lymphoma/leukemia 11A isoform 2

      See identical proteins and their annotated locations for NP_001152761.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 3' coding region, compared to variant 4. The resulting protein (isoform 2) has a shorter C-terminus when it is compared to isoform 4.
      Source sequence(s)
      AA008362, AK004395, AK045556, BB853515, BY735002
      Consensus CDS
      CCDS48758.1
      UniProtKB/Swiss-Prot
      Q9QYE3
      Related
      ENSMUSP00000105142.2, ENSMUST00000109516.8
    2. NM_001159290.1NP_001152762.1  B-cell lymphoma/leukemia 11A isoform 3

      See identical proteins and their annotated locations for NP_001152762.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, one of which results in the use of a downstream start codon, compared to variant 4. The resulting protein (isoform 3) is shorter when it is compared to isoform 4.
      Source sequence(s)
      AK045556
      Consensus CDS
      CCDS48759.1
      UniProtKB/Swiss-Prot
      Q9QYE3
      Related
      ENSMUSP00000112948.2, ENSMUST00000118955.2
    3. NM_001242934.1NP_001229863.1  B-cell lymphoma/leukemia 11A isoform 4

      See identical proteins and their annotated locations for NP_001229863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest protein (isoform 4).
      Source sequence(s)
      AK045556, AK140949, AK164574, BB649527, BB662872, BF731393, BY735002, CB524780, CD355476
      Consensus CDS
      CCDS56764.1
      UniProtKB/TrEMBL
      Q3US10, Q5STS9
      Related
      ENSMUSP00000105140.2, ENSMUST00000109514.8
      Conserved Domains (3) summary
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain
    4. NM_016707.3NP_057916.1  B-cell lymphoma/leukemia 11A isoform 1

      See identical proteins and their annotated locations for NP_057916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses a different splice site in the 3' coding region, compared to variant 4. The resulting protein (isoform 1) has a shorter C-terminus when it is compared to isoform 4.
      Source sequence(s)
      AF169037, AL672018, BB649527, BY735002
      Consensus CDS
      CCDS24483.1
      UniProtKB/Swiss-Prot
      Q80T89, Q8BLC7, Q8BLR4, Q8BWX3, Q921V4, Q9D0V2, Q9JIT4, Q9JLK8, Q9JLK9, Q9QYE3
      UniProtKB/TrEMBL
      Q3US10
      Related
      ENSMUSP00000000881.7, ENSMUST00000000881.13
      Conserved Domains (3) summary
      sd00017
      Location:379399
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:378399
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      24026498..24123558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156319.1XP_036012212.1  B-cell lymphoma/leukemia 11A isoform X6

      UniProtKB/Swiss-Prot
      Q80T89, Q8BLC7, Q8BLR4, Q8BWX3, Q921V4, Q9D0V2, Q9JIT4, Q9JLK8, Q9JLK9, Q9QYE3
      UniProtKB/TrEMBL
      Q3US10
      Conserved Domains (3) summary
      sd00017
      Location:379399
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:378399
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain
    2. XM_036156320.1XP_036012213.1  B-cell lymphoma/leukemia 11A isoform X9

    3. XM_036156315.1XP_036012208.1  B-cell lymphoma/leukemia 11A isoform X1

      UniProtKB/TrEMBL
      Q3US10, Q5STS9
      Conserved Domains (3) summary
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain
    4. XM_036156318.1XP_036012211.1  B-cell lymphoma/leukemia 11A isoform X1

      UniProtKB/TrEMBL
      Q3US10, Q5STS9
      Conserved Domains (3) summary
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain
    5. XM_036156314.1XP_036012207.1  B-cell lymphoma/leukemia 11A isoform X1

      UniProtKB/TrEMBL
      Q3US10, Q5STS9
      Conserved Domains (3) summary
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain
    6. XM_011243659.3XP_011241961.1  B-cell lymphoma/leukemia 11A isoform X2

      UniProtKB/TrEMBL
      Q3US10
      Conserved Domains (4) summary
      sd00017
      Location:379399
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain
    7. XM_036156321.1XP_036012214.1  B-cell lymphoma/leukemia 11A isoform X9

    8. XM_036156316.1XP_036012209.1  B-cell lymphoma/leukemia 11A isoform X1

      UniProtKB/TrEMBL
      Q3US10, Q5STS9
      Conserved Domains (3) summary
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain
    9. XM_006514504.4XP_006514567.1  B-cell lymphoma/leukemia 11A isoform X1

      See identical proteins and their annotated locations for XP_006514567.1

      UniProtKB/TrEMBL
      Q3US10, Q5STS9
      Conserved Domains (3) summary
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain
    10. XM_030245548.2XP_030101408.1  B-cell lymphoma/leukemia 11A isoform X9

    11. XM_036156322.1XP_036012215.1  B-cell lymphoma/leukemia 11A isoform X9

    12. XM_030245543.2XP_030101403.1  B-cell lymphoma/leukemia 11A isoform X4

      UniProtKB/TrEMBL
      Q3US10
      Conserved Domains (4) summary
      sd00017
      Location:345365
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:710730
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:709730
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:357382
      zf-H2C2_2; Zinc-finger double domain
    13. XM_011243660.3XP_011241962.1  B-cell lymphoma/leukemia 11A isoform X3

      UniProtKB/TrEMBL
      Q3US10
      Conserved Domains (3) summary
      sd00017
      Location:710730
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:709730
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:357382
      zf-H2C2_2; Zinc-finger double domain
    14. XM_036156317.1XP_036012210.1  B-cell lymphoma/leukemia 11A isoform X1

      UniProtKB/TrEMBL
      Q3US10, Q5STS9
      Conserved Domains (3) summary
      sd00017
      Location:744764
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:743764
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:391416
      zf-H2C2_2; Zinc-finger double domain
    15. XM_030245545.1XP_030101405.1  B-cell lymphoma/leukemia 11A isoform X7

      UniProtKB/TrEMBL
      Q3US10
      Conserved Domains (3) summary
      sd00017
      Location:658678
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:657678
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305330
      zf-H2C2_2; Zinc-finger double domain
    16. XM_030245547.2XP_030101407.1  B-cell lymphoma/leukemia 11A isoform X8

      UniProtKB/TrEMBL
      Q3US10
      Conserved Domains (3) summary
      sd00019
      Location:327347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:326347
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:339364
      zf-H2C2_2; Zinc-finger double domain
    17. XM_006514507.4XP_006514570.1  B-cell lymphoma/leukemia 11A isoform X5

      UniProtKB/TrEMBL
      Q3US10
      Conserved Domains (3) summary
      sd00017
      Location:692712
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:691712
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:339364
      zf-H2C2_2; Zinc-finger double domain