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    Htr2a 5-hydroxytryptamine receptor 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29595, updated on 23-May-2018
    Official Symbol
    Htr2aprovided by RGD
    Official Full Name
    5-hydroxytryptamine receptor 2Aprovided by RGD
    Primary source
    RGD:61800
    See related
    Ensembl:ENSRNOG00000010063
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    5Ht-2; 5-HT2A
    Summary
    a receptor for 5-hydroxytryptamine (serotonin); activates phospholipase C signaling pathway; involved in promoting cellular transformation [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 49.5), Heart (RPKM 14.5) and 6 other tissues See more
    Orthologs
    See Htr2a in Genome Data Viewer
    Location:
    15q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (56666152..56732469)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (60388557..60454874)

    Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546424 Neighboring gene uncharacterized LOC102546539 Neighboring gene esterase D Neighboring gene leucine rich repeats and calponin homology domain containing 1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding IEA
    Inferred from Electronic Annotation
    more info
     
    1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein alpha-subunit binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G-protein coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G-protein coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G-protein coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serotonin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serotonin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    artery smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral response to cocaine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    detection of mechanical stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of temperature stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase C-activating G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phospholipase C-activating serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    serotonin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    temperature homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    urinary bladder smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    caveola IEA
    Inferred from Electronic Annotation
    more info
     
    cell body fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    5-hydroxytryptamine receptor 2A
    Names
    5-HT-2
    5-HT-2A
    5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
    serotonin 5HT-2 receptor
    serotonin receptor 2A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017254.1NP_058950.1  5-hydroxytryptamine receptor 2A

      See identical proteins and their annotated locations for NP_058950.1

      Status: PROVISIONAL

      Source sequence(s)
      M30705
      UniProtKB/Swiss-Prot
      P14842
      Related
      ENSRNOP00000013408.4, ENSRNOT00000013408.6
      Conserved Domains (2) summary
      pfam00001
      Location:91380
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:89207
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005114.4 Reference Rnor_6.0 Primary Assembly

      Range
      56666152..56732469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000083.1 Alternate Rn_Celera

      Range
      49584210..49652169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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