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    NSMCE1 NSE1 homolog, SMC5-SMC6 complex component [ Homo sapiens (human) ]

    Gene ID: 197370, updated on 2-Mar-2021

    Summary

    Official Symbol
    NSMCE1provided by HGNC
    Official Full Name
    NSE1 homolog, SMC5-SMC6 complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:29897
    See related
    Ensembl:ENSG00000169189 MIM:617263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NSE1
    Expression
    Ubiquitous expression in testis (RPKM 20.3), prostate (RPKM 15.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NSMCE1 in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210226 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (27224994..27268772, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (27236315..27280093, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2129 Neighboring gene lysine demethylase 8 Neighboring gene NSMCE1 divergent transcript Neighboring gene interleukin 4 receptor Neighboring gene interleukin 21 receptor Neighboring gene IL21R antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    non-structural maintenance of chromosomes element 1 homolog
    Names
    non-SMC element 1 homolog
    NP_659547.2
    XP_006721086.1
    XP_011544064.1
    XP_016878529.1
    XP_016878530.1
    XP_016878531.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145080.4NP_659547.2  non-structural maintenance of chromosomes element 1 homolog

      See identical proteins and their annotated locations for NP_659547.2

      Status: VALIDATED

      Source sequence(s)
      BU685363, DB463393
      Consensus CDS
      CCDS10628.2
      UniProtKB/Swiss-Prot
      Q8WV22
      Related
      ENSP00000355077.4, ENST00000361439.9
      Conserved Domains (2) summary
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      pfam08746
      Location:191231
      zf-RING-like; RING-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      27224994..27268772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721023.4XP_006721086.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      See identical proteins and their annotated locations for XP_006721086.1

      UniProtKB/Swiss-Prot
      Q8WV22
      Conserved Domains (2) summary
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      pfam08746
      Location:191231
      zf-RING-like; RING-like domain
    2. XM_011545762.1XP_011544064.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

      See identical proteins and their annotated locations for XP_011544064.1

      Conserved Domains (2) summary
      pfam07574
      Location:179
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      pfam08746
      Location:95135
      zf-RING-like; RING-like domain
    3. XM_017023041.1XP_016878530.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

      Conserved Domains (2) summary
      pfam07574
      Location:179
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      pfam08746
      Location:95135
      zf-RING-like; RING-like domain
    4. XM_017023040.1XP_016878529.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

      Conserved Domains (2) summary
      pfam07574
      Location:179
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      pfam08746
      Location:95135
      zf-RING-like; RING-like domain
    5. XM_017023042.1XP_016878531.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

      Conserved Domains (2) summary
      pfam07574
      Location:179
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
      pfam08746
      Location:95135
      zf-RING-like; RING-like domain

    RNA

    1. XR_002957792.1 RNA Sequence

      Related
      ENST00000565070.5
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