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    SPAG16 sperm associated antigen 16 [ Homo sapiens (human) ]

    Gene ID: 79582, updated on 7-Jun-2020

    Summary

    Official Symbol
    SPAG16provided by HGNC
    Official Full Name
    sperm associated antigen 16provided by HGNC
    Primary source
    HGNC:HGNC:23225
    See related
    Ensembl:ENSG00000144451 MIM:612173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PF20; WDR29
    Summary
    Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008]
    Expression
    Broad expression in testis (RPKM 2.7), thyroid (RPKM 1.2) and 24 other tissues See more
    Orthologs

    Genomic context

    See SPAG16 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (213284369..214410501)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (214149103..215275225)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985981 Neighboring gene SPAG16 divergent transcript Neighboring gene microRNA 4438 Neighboring gene uncharacterized LOC101928084 Neighboring gene ribosomal protein L5 pseudogene 8 Neighboring gene von Willebrand factor C domain containing 2 like Neighboring gene VWC2L intronic transcript 1 Neighboring gene endosulfine alpha pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of sperm associated antigen 16 (SPAG16) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22724, FLJ37717, MGC87036, DKFZp666P1710

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sperm axoneme assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axonemal central apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sperm-associated antigen 16 protein
    Names
    WD repeat domain 29
    pf20 protein homolog
    sperm-associated WD repeat protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025436.2NP_001020607.1  sperm-associated antigen 16 protein isoform 2

      See identical proteins and their annotated locations for NP_001020607.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and lacks a large portion of the 3' coding region, compared to variant 1. The encoded isoform (2) is significantly shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC025379, BC067756, CA313710
      Consensus CDS
      CCDS46508.1
      UniProtKB/Swiss-Prot
      Q8N0X2
      UniProtKB/TrEMBL
      Q4G1A2
      Related
      ENSP00000415079.2, ENST00000432529.6
    2. NM_024532.5NP_078808.3  sperm-associated antigen 16 protein isoform 1

      See identical proteins and their annotated locations for NP_078808.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF310672, AF490390, AK302351
      Consensus CDS
      CCDS2396.1
      UniProtKB/Swiss-Prot
      Q8N0X2
      UniProtKB/TrEMBL
      B4DYB5, Q4G1A2
      Related
      ENSP00000332592.5, ENST00000331683.10
      Conserved Domains (4) summary
      COG2319
      Location:341631
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:344631
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:355392
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:160271
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RNA

    1. NR_047659.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK302351, AW207406, BC025379
      Related
      ENST00000406979.6
    2. NR_047660.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK302351, BC025379

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      213284369..214410501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004896.1XP_016860385.1  sperm-associated antigen 16 protein isoform X11

      Conserved Domains (4) summary
      COG2319
      Location:222512
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:225512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:236273
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:41152
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    2. XM_011511814.1XP_011510116.1  sperm-associated antigen 16 protein isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:310600
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:313600
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:324361
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:129240
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    3. XM_011511820.2XP_011510122.1  sperm-associated antigen 16 protein isoform X7

      Conserved Domains (4) summary
      COG2319
      Location:302569
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:344569
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:355392
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:160271
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    4. XM_011511815.2XP_011510117.1  sperm-associated antigen 16 protein isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:342577
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:348580
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:356392
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:160271
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    5. XM_011511817.2XP_011510119.1  sperm-associated antigen 16 protein isoform X4

      Conserved Domains (3) summary
      COG2319
      Location:341561
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:348551
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:356392
      7WD40; WD40 repeat [structural motif]
    6. XM_011511816.3XP_011510118.1  sperm-associated antigen 16 protein isoform X3

      Conserved Domains (4) summary
      COG2319
      Location:343585
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:348551
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:356392
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:160271
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    7. XM_011511818.2XP_011510120.1  sperm-associated antigen 16 protein isoform X5

      Conserved Domains (4) summary
      COG2319
      Location:341561
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:348551
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:356392
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:160271
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    8. XM_011511824.2XP_011510126.1  sperm-associated antigen 16 protein isoform X10

      Conserved Domains (3) summary
      COG2319
      Location:341516
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:348518
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:356392
      7WD40; WD40 repeat [structural motif]
    9. XM_011511831.2XP_011510133.1  sperm-associated antigen 16 protein isoform X16

      See identical proteins and their annotated locations for XP_011510133.1

    10. XM_011511832.2XP_011510134.1  sperm-associated antigen 16 protein isoform X17

      See identical proteins and their annotated locations for XP_011510134.1

    11. XM_011511828.2XP_011510130.1  sperm-associated antigen 16 protein isoform X14

    12. XM_011511829.2XP_011510131.1  sperm-associated antigen 16 protein isoform X15

    13. XM_011511827.2XP_011510129.1  sperm-associated antigen 16 protein isoform X13

    14. XM_011511837.3XP_011510139.1  sperm-associated antigen 16 protein isoform X21

    15. XM_006712746.3XP_006712809.1  sperm-associated antigen 16 protein isoform X19

      Related
      ENSP00000272898.8, ENST00000272898.11
    16. XM_017004899.2XP_016860388.1  sperm-associated antigen 16 protein isoform X18

    17. XM_011511822.1XP_011510124.1  sperm-associated antigen 16 protein isoform X9

      See identical proteins and their annotated locations for XP_011510124.1

      Conserved Domains (4) summary
      COG2319
      Location:238528
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:241528
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:252289
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:57168
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    18. XM_011511821.2XP_011510123.1  sperm-associated antigen 16 protein isoform X8

      See identical proteins and their annotated locations for XP_011510123.1

      UniProtKB/TrEMBL
      B4DYB5
      Conserved Domains (4) summary
      COG2319
      Location:247537
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:250537
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:261298
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:66177
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    19. XM_011511823.3XP_011510125.1  sperm-associated antigen 16 protein isoform X9

      See identical proteins and their annotated locations for XP_011510125.1

      Conserved Domains (4) summary
      COG2319
      Location:238528
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:241528
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:252289
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:57168
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    20. XM_011511819.2XP_011510121.1  sperm-associated antigen 16 protein isoform X6

      Conserved Domains (4) summary
      COG2319
      Location:287577
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:290577
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:301338
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:106217
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    21. XM_017004897.1XP_016860386.1  sperm-associated antigen 16 protein isoform X11

      Conserved Domains (4) summary
      COG2319
      Location:222512
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:225512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:236273
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:41152
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    22. XM_017004898.1XP_016860387.1  sperm-associated antigen 16 protein isoform X12

    23. XM_024453140.1XP_024308908.1  sperm-associated antigen 16 protein isoform X20

      Conserved Domains (2) summary
      cd00200
      Location:38325
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4986
      7WD40; WD40 repeat [structural motif]
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