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    DPP10 dipeptidyl peptidase like 10 [ Homo sapiens (human) ]

    Gene ID: 57628, updated on 1-Aug-2020

    Summary

    Official Symbol
    DPP10provided by HGNC
    Official Full Name
    dipeptidyl peptidase like 10provided by HGNC
    Primary source
    HGNC:HGNC:20823
    See related
    Ensembl:ENSG00000175497 MIM:608209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPL2; DPPY; DPRP3; DPRP-3
    Summary
    This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 7.5), adrenal (RPKM 2.9) and 2 other tissues See more
    Orthologs

    Genomic context

    See DPP10 in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (114442641..115845780)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (115199899..116603328)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene selenophosphate synthetase 1 pseudogene 7 Neighboring gene RNA, U2 small nuclear 41, pseudogene Neighboring gene DPP10 antisense RNA 3 Neighboring gene uncharacterized LOC105373575 Neighboring gene uncharacterized LOC105373574 Neighboring gene uncharacterized LOC107985937 Neighboring gene DPP10 antisense RNA 1 Neighboring gene uncharacterized LOC107985938 Neighboring gene ribosomal protein SA pseudogene 23 Neighboring gene uncharacterized LOC105373572 Neighboring gene uncharacterized LOC105373576 Neighboring gene MT-CYB pseudogene 39

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog
    Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT dipeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    voltage-gated potassium channel complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    inactive dipeptidyl peptidase 10
    Names
    DPP X
    dipeptidyl peptidase 10
    dipeptidyl peptidase IV-related protein 3
    dipeptidyl peptidase X
    dipeptidyl peptidase-like protein 2
    dipeptidyl-peptidase 10 (inactive)
    dipeptidyl-peptidase 10 (non-functional)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004360.4NP_001004360.3  inactive dipeptidyl peptidase 10 isoform short

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 3. The resulting isoform (short, also referred to as DPL2-s and d) has a shorter and distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC016721, AC017040, AC066593, AC067947, AC105422
      Consensus CDS
      CCDS33278.1
      Related
      ENSP00000309066.8, ENST00000310323.12
    2. NM_001178034.1NP_001171505.1  inactive dipeptidyl peptidase 10 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC066593, DQ857322
      Consensus CDS
      CCDS54388.1
      UniProtKB/Swiss-Prot
      Q8N608
      Related
      ENSP00000376855.2, ENST00000393147.6
      Conserved Domains (2) summary
      pfam00326
      Location:584786
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:137503
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    3. NM_001178036.2NP_001171507.2  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon, as compared to variant 3. The resulting isoform (a) has a shorter and distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS54389.1
      Related
      ENSP00000387038.1, ENST00000409163.5
    4. NM_001178037.2NP_001171508.2  inactive dipeptidyl peptidase 10 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 3. The resulting isoform (b) has a shorter and distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC016721, AC017040, AC067947, AC093610, AC105422
    5. NM_001321905.2NP_001308834.2  inactive dipeptidyl peptidase 10 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC012071, AC016721, AC017040, AC067947, AC105422
    6. NM_001321906.2NP_001308835.2  inactive dipeptidyl peptidase 10 isoform short

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC066593, BM974067, DQ857322
      Consensus CDS
      CCDS33278.1
    7. NM_001321907.2NP_001308836.2  inactive dipeptidyl peptidase 10 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
    8. NM_001321908.2NP_001308837.2  inactive dipeptidyl peptidase 10 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
    9. NM_001321909.2NP_001308838.2  inactive dipeptidyl peptidase 10 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC017040, AC066593, AC067947, AC105422
    10. NM_001321910.2NP_001308839.2  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC012071, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS54389.1
    11. NM_001321911.2NP_001308840.2  inactive dipeptidyl peptidase 10 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS54389.1
    12. NM_001321912.2NP_001308841.2  inactive dipeptidyl peptidase 10 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
    13. NM_001321913.2NP_001308842.2  inactive dipeptidyl peptidase 10 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
    14. NM_001321914.2NP_001308843.2  inactive dipeptidyl peptidase 10 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC016721, AC066593, BM974067, DQ857322
    15. NM_020868.6NP_065919.3  inactive dipeptidyl peptidase 10 isoform long

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has an alternate 5' exon, as compared to variant 3. The resulting isoform (long, also referred to as DPL2-l) is slightly shorter and has a distinct N-terminus when compared to isoform c.
      Source sequence(s)
      AC010885, AC016721, AC017040, AC067947, AC105422
      Consensus CDS
      CCDS46400.1
      Related
      ENSP00000386565.1, ENST00000410059.6

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      114442641..115845780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453023.1XP_024308791.1  inactive dipeptidyl peptidase 10 isoform X1

      Conserved Domains (2) summary
      pfam00326
      Location:560762
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:126479
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    2. XM_017004566.1XP_016860055.1  inactive dipeptidyl peptidase 10 isoform X2

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