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    TNC tenascin C [ Homo sapiens (human) ]

    Gene ID: 3371, updated on 9-Apr-2026
    Official Symbol
    TNCprovided by HGNC
    Official Full Name
    tenascin Cprovided by HGNC
    Primary source
    HGNC:HGNC:5318
    See related
    Ensembl:ENSG00000041982 MIM:187380; AllianceGenome:HGNC:5318
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225
    Summary
    This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
    Expression
    Broad expression in appendix (RPKM 76.9), endometrium (RPKM 19.4) and 15 other tissues See more
    Orthologs
    Try the new Gene page
    Try the new Transcripts and proteins table
    See TNC in Genome Data Viewer
    Location:
    9q33.1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (115019575..115118157, complement)
    RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (127212162..127310465, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117781854..117880436, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor kinase PRP4K pseudogene Neighboring gene Sharpr-MPRA regulatory region 6981 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:117656118-117657317 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:117669626-117670248 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:117670249-117670870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:117691965-117692524 Neighboring gene TNF superfamily member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28881 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:117797665-117798864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28882 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:117825442-117826641 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:117827001-117827743 Neighboring gene uncharacterized LOC124902256 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:117838052-117838579 Neighboring gene uncharacterized LOC124902255 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:117876192-117877391 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:117880715-117881534 Neighboring gene uncharacterized LOC101928748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:117894654-117895154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:117895155-117895655 Neighboring gene uncharacterized LOC124902257 Neighboring gene deleted in esophageal cancer 1

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Associated conditions

    Description Tests
    Autosomal dominant nonsyndromic hearing loss 56
    MedGen: C3810170 OMIM: 615629 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Replication interactions

    Interaction Pubs
    HIV-1 is inhibited by TNC (tenascin C), MUC1, and LTF (lactoferrin) as shown through neutralization assays in TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Preincubation of HIV-1 gp160 and gp120 glycoproteins with soluble CD4 enhances the TNC binding, whereas antibodies against the V3 loop of the Env protein block the TNC binding PubMed
    env Tenascin-C (TNC), an extracellular matrix protein isolated from breast milk, has the HIV-1 neutralization activity by binding to HIV-1 gp160 and gp120 glycoproteins PubMed
    Envelope surface glycoprotein gp160, precursor env Preincubation of HIV-1 gp160 and gp120 glycoproteins with soluble CD4 enhances the TNC binding, whereas antibodies against the V3 loop of the Env protein block the TNC binding PubMed
    env Tenascin-C (TNC), an extracellular matrix protein isolated from breast milk, has the HIV-1 neutralization activity by binding to HIV-1 gp160 and gp120 glycoproteins PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tenascin C (TNC) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • MGC167029

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syndecan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in morphogenesis of an epithelium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast differentiation HDA PubMed 
    involved_in regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Preferred Names
    tenascin
    Names
    GP 150-225
    cytotactin
    deafness, autosomal dominant 56
    glioma-associated-extracellular matrix antigen
    hexabrachion (tenascin)
    myotendinous antigen
    neuronectin
    tenascin-C additional domain 1

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029637.1 RefSeqGene

      Range
      5101..103683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001410991.1NP_001397920.1  tenascin isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      Consensus CDS
      CCDS94467.1
      UniProtKB/TrEMBL
      E9PC84, J3QSU6
    2. NM_001439065.1NP_001425994.1  tenascin isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    3. NM_001439066.1NP_001425995.1  tenascin isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    4. NM_001439067.1NP_001425996.1  tenascin isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    5. NM_001439068.1NP_001425997.1  tenascin isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    6. NM_001439069.1NP_001425998.1  tenascin isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    7. NM_001439070.1NP_001425999.1  tenascin isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    8. NM_001439071.1NP_001426000.1  tenascin isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    9. NM_001439072.1NP_001426001.1  tenascin isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    10. NM_001439073.1NP_001426002.1  tenascin isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    11. NM_001439074.1NP_001426003.1  tenascin isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    12. NM_001439075.1NP_001426004.1  tenascin isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/Swiss-Prot
      C9IYT7, C9J575, C9J6D9, C9J848, P24821, Q14583, Q15567, Q5T7S3
      UniProtKB/TrEMBL
      Q4LE33
    13. NM_001439076.1NP_001426005.1  tenascin isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/Swiss-Prot
      C9IYT7, C9J575, C9J6D9, C9J848, P24821, Q14583, Q15567, Q5T7S3
      UniProtKB/TrEMBL
      Q4LE33
    14. NM_001439077.1NP_001426006.1  tenascin isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
      Related
      ENSP00000516085.1, ENST00000705192.1
    15. NM_001439078.1NP_001426007.1  tenascin isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    16. NM_001439079.1NP_001426008.1  tenascin isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    17. NM_001439080.1NP_001426009.1  tenascin isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    18. NM_001439081.1NP_001426010.1  tenascin isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    19. NM_001439082.1NP_001426011.1  tenascin isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      Q4LE33
    20. NM_001439083.1NP_001426012.1  tenascin isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84, J3QSU6
      Related
      ENSP00000339553.4, ENST00000341037.8
    21. NM_001439084.1NP_001426013.1  tenascin isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84
      Related
      ENSP00000571504.1, ENST00000901445.1
    22. NM_001439085.1NP_001426014.1  tenascin isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84
    23. NM_001439086.1NP_001426015.1  tenascin isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84
    24. NM_001439087.1NP_001426016.1  tenascin isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84
      Related
      ENSP00000571511.1, ENST00000901452.1
    25. NM_001439088.1NP_001426017.1  tenascin isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84
    26. NM_001439089.1NP_001426018.1  tenascin isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84
    27. NM_001439090.1NP_001426019.1  tenascin isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      F5H7V9
      Related
      ENSP00000602108.1, ENST00000932049.1
    28. NM_001439091.1NP_001426020.1  tenascin isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84
    29. NM_001439092.1NP_001426021.1  tenascin isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84
    30. NM_001439093.1NP_001426022.1  tenascin isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84
      Related
      ENSP00000571503.1, ENST00000901444.1
    31. NM_001439094.1NP_001426023.1  tenascin isoform 16 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      F5H7V9
    32. NM_001439095.1NP_001426024.1  tenascin isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      E9PC84
    33. NM_001439096.1NP_001426025.1  tenascin isoform 17 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      F5H7V9
    34. NM_001439097.1NP_001426026.1  tenascin isoform 18 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      F5H7V9
      Related
      ENSP00000571502.1, ENST00000901443.1
    35. NM_001439098.1NP_001426027.1  tenascin isoform 19 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      F5H7V9
      Related
      ENSP00000571510.1, ENST00000901451.1
    36. NM_001439099.1NP_001426028.1  tenascin isoform 20 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      F5H7V9
      Related
      ENSP00000443478.1, ENST00000537320.6
    37. NM_001439100.1NP_001426029.1  tenascin isoform 20 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      F5H7V9
    38. NM_001439101.1NP_001426030.1  tenascin isoform 20 precursor

      Status: REVIEWED

      Source sequence(s)
      AL162425
      UniProtKB/TrEMBL
      F5H7V9
      Related
      ENSP00000638492.1, ENST00000968433.1
    39. NM_002160.4NP_002151.2  tenascin isoform 1 precursor

      See identical proteins and their annotated locations for NP_002151.2

      Status: REVIEWED

      Source sequence(s)
      AB210038, AI266750, AI964017, AK304015, BP279008, BU860660, BX100095, X78565
      Consensus CDS
      CCDS6811.1
      UniProtKB/Swiss-Prot
      C9IYT7, C9J575, C9J6D9, C9J848, P24821, Q14583, Q15567, Q5T7S3
      UniProtKB/TrEMBL
      Q4LE33
      Related
      ENSP00000265131.4, ENST00000350763.9
      Conserved Domains (3) summary
      pfam00147
      Location:19802189
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
      pfam00041
      Location:18881960
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      115019575..115118157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518626.4XP_011516928.1  tenascin isoform X13

      UniProtKB/TrEMBL
      F5H7V9
      Related
      ENSP00000442242.1, ENST00000542877.6
      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:16161688
      fn3; Fibronectin type III domain
      pfam00147
      Location:17081917
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:468496
      EGF_2; EGF-like domain
    2. XM_017014681.3XP_016870170.1  tenascin isoform X10

      UniProtKB/TrEMBL
      F5H7V9
    3. XM_047423310.1XP_047279266.1  tenascin isoform X1

      UniProtKB/TrEMBL
      Q4LE33

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      127212162..127310465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362882.1XP_054218857.1  tenascin isoform X13

      UniProtKB/TrEMBL
      F5H7V9
    2. XM_054362864.1XP_054218839.1  tenascin isoform X2

      UniProtKB/TrEMBL
      Q4LE33
    3. XM_054362865.1XP_054218840.1  tenascin isoform X2

      UniProtKB/TrEMBL
      Q4LE33
    4. XM_054362881.1XP_054218856.1  tenascin isoform X12

      UniProtKB/TrEMBL
      E9PC84
    5. XM_054362866.1XP_054218841.1  tenascin isoform X2

      UniProtKB/TrEMBL
      Q4LE33