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    TAFA4 TAFA chemokine like family member 4 [ Homo sapiens (human) ]

    Gene ID: 151647, updated on 3-Mar-2026
    Official Symbol
    TAFA4provided by HGNC
    Official Full Name
    TAFA chemokine like family member 4provided by HGNC
    Primary source
    HGNC:HGNC:21591
    See related
    Ensembl:ENSG00000163377 MIM:617498; AllianceGenome:HGNC:21591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAFA-4; FAM19A4
    Summary
    This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Biased expression in adrenal (RPKM 8.7), gall bladder (RPKM 0.7) and 1 other tissue See more
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See TAFA4 in Genome Data Viewer
    Location:
    3p14.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (68731766..68932547, complement)
    RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (68769008..68969284, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (68780917..68981698, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:68693138-68693638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:68693639-68694139 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 8 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:68859761-68860260 Neighboring gene RNA, 5S ribosomal pseudogene 135 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:68968097-68968699 Neighboring gene Sharpr-MPRA regulatory region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14515 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene EOGT divergent transcript Neighboring gene TATA element modulatory factor 1 Neighboring gene microRNA 3136

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Related articles in PubMed

    1. Methylation analysis of the FAM19A4 gene in cervical scrapes is highly efficient in detecting cervical carcinomas and advanced CIN2/3 lesions. De Strooper LM, et al. Cancer Prev Res (Phila), 2014 Dec. PMID 25281488
    2. Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study). Luttmer R, et al. Int J Cancer, 2016 Feb 15. PMID 26317579
    3. FAM19A4 methylation analysis in self-samples compared with cervical scrapes for detecting cervical (pre)cancer in HPV-positive women. Luttmer R, et al. Br J Cancer, 2016 Aug 23. PMID 27415009, Free PMC Article
    4. The clinical significance of FAM19A4 methylation in high-risk HPV-positive cervical samples for the detection of cervical (pre)cancer in Chinese women. Bu Q, et al. BMC Cancer, 2018 Nov 29. PMID 30486875, Free PMC Article
    5. [Detection and analysis of FAM19A4 promoter methylation in cervical exfoliated cells]. Wang SF, et al. Zhonghua Yi Xue Za Zhi, 2019 Jul 2. PMID 31269601

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcepsilonRI in mast cells.
      Title: Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcεRI in mast cells.
    2. FAM19A4/miR124-2 Methylation Testing and Human Papillomavirus (HPV) 16/18 Genotyping in HPV-Positive Women Under the Age of 30 Years.
      Title: FAM19A4/miR124-2 Methylation Testing and Human Papillomavirus (HPV) 16/18 Genotyping in HPV-Positive Women Under the Age of 30 Years.
    3. Full genotyping and FAM19A4/miR124-2 methylation analysis in high-risk human papillomavirus-positive samples from women over 30 years participating in cervical cancer screening in Orebro, Sweden.
      Title: Full genotyping and FAM19A4/miR124-2 methylation analysis in high-risk human papillomavirus-positive samples from women over 30 years participating in cervical cancer screening in Örebro, Sweden.
    4. Clinical Regression of High-Grade Cervical Intraepithelial Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA Methylation (CONCERVE Study).
      Title: Clinical Regression of High-Grade Cervical Intraepithelial Neoplasia Is Associated With Absence of FAM19A4/miR124-2 DNA Methylation (CONCERVE Study).
    5. Risk-stratification of HPV-positive women with low-grade cytology by FAM19A4/miR124-2 methylation and HPV genotyping.
      Title: Risk-stratification of HPV-positive women with low-grade cytology by FAM19A4/miR124-2 methylation and HPV genotyping.
    6. Methylation markers FAM19A4 and miR124-2 as triage strategy for primary human papillomavirus screen positive women: A large European multicenter study.
      Title: Methylation markers FAM19A4 and miR124-2 as triage strategy for primary human papillomavirus screen positive women: A large European multicenter study.
    7. Expression of p16 and HPV E4 on biopsy samples and methylation of FAM19A4 and miR124-2 on cervical cytology samples in the classification of cervical squamous intraepithelial lesions.
      Title: Expression of p16 and HPV E4 on biopsy samples and methylation of FAM19A4 and miR124-2 on cervical cytology samples in the classification of cervical squamous intraepithelial lesions.
    8. FAM19A4/miR124-2 methylation in invasive cervical cancer: A retrospective cross-sectional worldwide study.
      Title: FAM19A4/miR124-2 methylation in invasive cervical cancer: A retrospective cross-sectional worldwide study.
    9. The use of molecular markers for cervical screening of women living with HIV in South Africa.
      Title: The use of molecular markers for cervical screening of women living with HIV in South Africa.
    10. Among HPV positive women aged >/=30 years, a negative FAM19A4/miR124-2 methylation test provides a similar safety in terms of long-term CIN3+ risk compared with a negative cytology test, while the CIN3+risk following a positive methylation test justifies immediate colposcopy referral.
      Title: Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ25161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor ligand activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macrophage chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in superoxide anion generation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    chemokine-like protein TAFA-4
    Names
    family with sequence similarity 19 (chemokine (C-C motif)-like), member A4
    family with sequence similarity 19 member A4, C-C motif chemokine like
    protein FAM19A4

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005527.3 → NP_001005527.1  chemokine-like protein TAFA-4 precursor

      See identical proteins and their annotated locations for NP_001005527.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC096922, BC031566, DA017279
      Consensus CDS
      CCDS2907.1
      UniProtKB/Swiss-Prot
      A8MVT2, Q96LR4
      Related
      ENSP00000587866.1, ENST00000917807.1
      Conserved Domains (1) summary
      pfam12020
      Location:50 → 138
      TAFA; TAFA family

    2. NM_182522.5 → NP_872328.1  chemokine-like protein TAFA-4 precursor

      See identical proteins and their annotated locations for NP_872328.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC096922, AY325117
      Consensus CDS
      CCDS2907.1
      UniProtKB/Swiss-Prot
      A8MVT2, Q96LR4
      Related
      ENSP00000295569.7, ENST00000295569.12
      Conserved Domains (1) summary
      pfam12020
      Location:50 → 138
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      68731766..68932547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533372.2 → XP_011531674.1  chemokine-like protein TAFA-4 isoform X1

      See identical proteins and their annotated locations for XP_011531674.1

      Conserved Domains (1) summary
      pfam12020
      Location:50 → 124
      TAFA; TAFA family

    2. XM_011533371.2 → XP_011531673.1  chemokine-like protein TAFA-4 isoform X1

      See identical proteins and their annotated locations for XP_011531673.1

      Conserved Domains (1) summary
      pfam12020
      Location:50 → 124
      TAFA; TAFA family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      68769008..68969284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345323.1 → XP_054201298.1  chemokine-like protein TAFA-4 isoform X1

    2. XM_054345322.1 → XP_054201297.1  chemokine-like protein TAFA-4 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LR4.1 GenPept UniProtKB/Swiss-Prot:Q96LR4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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