SCGB3A1 secretoglobin family 3A member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SCGB3A1provided by HGNC
Official Full Name: secretoglobin family 3A member 1provided by HGNC
Primary source: HGNC:HGNC:18384
See related: Ensembl:ENSG00000161055 MIM:606500; AllianceGenome:HGNC:18384
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HIN1; HIN-1; LU105; UGRP2; PnSP-2
Summary: Predicted to enable cytokine activity. Predicted to be involved in positive regulation of myoblast fusion. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in lung (RPKM 109.6), salivary gland (RPKM 64.7) and 1 other tissue See more
Orthologs: all
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Genomic context

Location:: 5q35.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (180590105..180591499, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (181145993..181147387, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (180017105..180018499, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HOXA9, RASSF1A and SCGB3A1 promoter methylation significantly associated with testicular germ cell tumor stage.
Title: DNA methylation profiling as a tool for testicular germ cell tumors subtyping.
Some single nucleotide polymorphisms and their combinations in the Ugrp2 gene are associated with an increased risk of developing adenoid hypertrophy.
Title: Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population.
The role of high in normal-1 (HIN-1) as a potential biomarker in combating glioblastoma is being described for the first time in this study.
Title: HIN-1: a New Epigenetic Biomarker Crucial for Therapy Selection in Glioblastoma Multiforme.
Tumor-adjacent tissues showed higher methylation status of RASSF1A, HIN-1 and MGMT promoters.
Title: Applicability of HIN-1, MGMT and RASSF1A promoter methylation as biomarkers for detecting field cancerization in breast cancer.
SCGB3A1-183 T and SCGB3A1 IVS1-189 A alleles might have a protective effect against nasal polyposis.
Title: Investigation of SCGB3A1 (UGRP2) gene arrays in patients with nasal polyposis.
aberrant HIN-1 promoter methylation could be an independent and important biomarker used in predicting the prognosis and progression of breast cancer
Title: Aberrant promoter methylation of HIN-1 gene may contribute to the pathogenesis of breast cancer: a meta-analysis.
Methylation of HIN-1 promoter is a novel epigenetic biomarker associated with poor outcomes in OCCA patients.
Title: Promoter methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma.
Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancers was associated with clinical characteristics, but only RASSF1A methylation was associated with time to first recurrence and overall survival.
Title: Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome.
HIN1, was the most "dietary sensitive" genes, as methylation of their promoters was associated with intakes of at least two out of the eight dietary methyl factors examined.
Title: The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study.
analysis of AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer
Title: AKT signaling pathway activated by HIN-1 methylation in non-small cell lung cancer.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secretoglobin family 3A member 1

Names: cytokine HIN-1; cytokine high in normal-1; high in normal 1; pneumo secretory protein 2; uteroglobin-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.