MCHR2 melanin concentrating hormone receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MCHR2provided by HGNC
Official Full Name: melanin concentrating hormone receptor 2provided by HGNC
Primary source: HGNC:HGNC:20867
See related: Ensembl:ENSG00000152034 MIM:606111; AllianceGenome:HGNC:20867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SLT; MCH2; MCH2R; GPR145; GPRv17; MCH-2R; MCH-R2; MCHR-2
Summary: Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in brain (RPKM 3.0) and testis (RPKM 2.4) See more
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Location:: 6q16.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (99918519..99994223, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (101091896..101168099, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (100366395..100442099, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results are in line with some previously performed studies suggesting that MCHR2 is not a major contributor to human obesity and the Prader Willi Syndrome phenotype
Title: DNA sequencing and copy number variation analysis of MCHR2 in a cohort of Prader Willi like (PWL) patients.
evidence for the involvement of duplications in MCHR2 in alopecia areata pathogenesis in a Central European cohort
Title: Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2.
This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression.
Title: Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.
Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2
Title: Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.
construction of the CHO cell line and the research of MCHR2 molecular characteristics have established a good experimental basis for the further research about the function of MCHR2 gene
Title: Establishment of CHO cell line expressing human MCHR2 gene and research of its molecular characteristics.
MCHR2 positively mediates the regulation of melanin-concentrating hormone during preadipocyte differentiation and is involved in energy balance regulation without affecting preadipocyte proliferation.
Title: Melanin-concentrating hormone receptor 2 affects 3T3-L1 preadipocyte differentiation.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.
Observational study of gene-disease association. (HuGE Navigator)
Title: A systematic association mapping on chromosome 6q in bipolar affective disorder--evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder.
MCHR2 is not a major contributor to polygenic obesity
Title: Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.
results of molecular simulations of MCHR2 in the free and hormone-bound forms provide suggestions on the amino acids responsible for the transfer of the structural changes from the agonist binding site to the G-protein coupling domains
Title: Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

PMC34708P1 (e-PCR)
- UniSTS:273234

PMC34708P2 (e-PCR)
- UniSTS:273235

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables galanin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables melanin-concentrating hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: melanin-concentrating hormone receptor 2

Names: G protein-coupled receptor slt; G-protein coupled receptor 145; MCH receptor 2; melanin-concentrating hormone 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040179.2 → NP_001035269.1 melanin-concentrating hormone receptor 2

See identical proteins and their annotated locations for NP_001035269.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK123634, AL590725

Consensus CDS

CCDS5044.1

UniProtKB/Swiss-Prot

B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8

Related

ENSP00000281806.2, ENST00000281806.7

Conserved Domains (1) summary

cd15339
Location:35 → 317

7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_032503.3 → NP_115892.2 melanin-concentrating hormone receptor 2

See identical proteins and their annotated locations for NP_115892.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK123634, AL590725

Consensus CDS

CCDS5044.1

UniProtKB/Swiss-Prot

B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8

Related

ENSP00000358214.1, ENST00000369212.2

Conserved Domains (1) summary

cd15339
Location:35 → 317

7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

99918519..99994223 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024446571.2 → XP_024302339.1 melanin-concentrating hormone receptor 2 isoform X1

UniProtKB/Swiss-Prot

B3KVW4, E1P5D7, Q5VTV7, Q6Q377, Q969V1, Q9BXA8

Related

ENSP00000550296.1, ENST00000880237.1

Conserved Domains (1) summary

cd15339
Location:35 → 317

7tmA_MCHR2; melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors