KLRC2 killer cell lectin like receptor C2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KLRC2provided by HGNC
Official Full Name: killer cell lectin like receptor C2provided by HGNC
Primary source: HGNC:HGNC:6375
See related: Ensembl:ENSG00000205809 MIM:602891; AllianceGenome:HGNC:6375
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NKG2C; CD159c; NKG2-C
Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 6.7), spleen (RPKM 3.4) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 12p13.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (10430599..10436010, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (10583198..10588609, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NKG2C and NKG2A coexpression defines a highly functional antiviral NK population in spontaneous HIV control.
Title: NKG2C and NKG2A coexpression defines a highly functional antiviral NK population in spontaneous HIV control.
Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells.
Title: Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells.
Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions.
Title: Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3'-untranslated regions.
Assessment of NKG2C copy number variation in HIV-1 infection susceptibility, and considerations about the potential role of lacking receptors and virus infection.
Title: Assessment of NKG2C copy number variation in HIV-1 infection susceptibility, and considerations about the potential role of lacking receptors and virus infection.
NKG2C+ NK Cells for Immunotherapy of Glioblastoma Multiforme.
Title: NKG2C+ NK Cells for Immunotherapy of Glioblastoma Multiforme.
Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation.
Title: Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation.
Increased Susceptibility of the CD57(-) NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response.
Title: Increased Susceptibility of the CD57(-) NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response.
Reduced expansion of CD94/NKG2C(+) NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions.
Title: Reduced expansion of CD94/NKG2C(+) NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions.
Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point.
Title: Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point.
Screening for the Biomarkers Associated with Myocardial Infarction by Bioinformatics Analysis.
Title: Screening for the Biomarkers Associated with Myocardial Infarction by Bioinformatics Analysis.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Interaction	Pubs
Knockdown of killer cell lectin-like receptor subfamily C, member 2 (KLRC2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC35438 (e-PCR)
- UniSTS:4199

KLRC1_2531 (e-PCR)
- UniSTS:280812

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MHC class I protein complex binding	IEA Inferred from Electronic Annotation more info
enables MHC class I protein complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables MHC class Ib receptor activity	IEA Inferred from Electronic Annotation more info
enables activating MHC class Ib receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables activating MHC class Ib receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein antigen binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular defense response	IEA Inferred from Electronic Annotation more info
involved_in cellular defense response	TAS Traceable Author Statement more info	PubMed
involved_in immune response-regulating cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell mediated immunity	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell mediated immunity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell degranulation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of natural killer cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in stimulatory C-type lectin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in stimulatory C-type lectin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of signaling receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of signaling receptor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NKG2-C type II integral membrane protein

Names: CD159 antigen-like family member C; NK cell receptor C; NKG2-C-activating NK receptor; killer cell lectin-like receptor subfamily C, member 2; natural killer cell receptor G2-C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002260.4 → NP_002251.2 NKG2-C type II integral membrane protein

See identical proteins and their annotated locations for NP_002251.2

Status: REVIEWED

Source sequence(s)

AC068775, AF260134, BC093644, X54869

Consensus CDS

CCDS31745.1

UniProtKB/Swiss-Prot

O43802, P26717, Q52M74, Q9NR42

UniProtKB/TrEMBL

A0A897PVC2

Related

ENSP00000371327.2, ENST00000381902.7

Conserved Domains (1) summary

cd03593
Location:117 → 229

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)