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    EHF ETS homologous factor [ Homo sapiens (human) ]

    Gene ID: 26298, updated on 6-Jul-2026
    Official Symbol
    EHFprovided by HGNC
    Official Full Name
    ETS homologous factorprovided by HGNC
    Primary source
    HGNC:HGNC:3246
    See related
    Ensembl:ENSG00000135373 MIM:605439; AllianceGenome:HGNC:3246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESE3; ESEJ; ESE3B
    Summary
    This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
    Expression
    Biased expression in esophagus (RPKM 89.9), colon (RPKM 60.6) and 12 other tissues See more
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See EHF in Genome Data Viewer
    Location:
    11p13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (34621093..34663288)
    RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (34757923..34800105)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (34642640..34684835)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:34517695-34518194 Neighboring gene E74 like ETS transcription factor 5 Neighboring gene Sharpr-MPRA regulatory region 13672 Neighboring gene long independently transcribed non-coding RNA 2707 Neighboring gene Sharpr-MPRA regulatory region 2953 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:34620676-34621875 Neighboring gene Sharpr-MPRA regulatory region 12213 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4606 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:34701712-34702911 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:34706267-34707466 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:34713481-34714124 Neighboring gene uncharacterized LOC102723568 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 2558 Neighboring gene NANOG hESC enhancer GRCh37_chr11:34817013-34817561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3252 Neighboring gene uncharacterized LOC105376625

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Related articles in PubMed

    1. ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. Fujikawa M, et al. Cancer Sci, 2007 Sep. PMID 17627613, Free PMC Article
    2. Ets homologous factor (EHF) has critical roles in epithelial dysfunction in airway disease. Fossum SL, et al. J Biol Chem, 2017 Jun 30. PMID 28461336, Free PMC Article
    3. Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer. Shi J, et al. Cell Death Dis, 2016 Oct 27. PMID 27787520, Free PMC Article
    4. Knockdown of EHF inhibited the proliferation, invasion and tumorigenesis of ovarian cancer cells. Cheng Z, et al. Mol Carcinog, 2016 Jun. PMID 26258986
    5. Abnormal Localization and Tumor Suppressor Function of Epithelial Tissue-Specific Transcription Factor ESE3 in Esophageal Squamous Cell Carcinoma. Wang L, et al. PLoS One, 2015. PMID 25950810, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
      Title: Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
    2. ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B.
      Title: ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B.
    3. Pancreatic cancer cell-derived microRNA-155-5p-containing extracellular vesicles promote immune evasion by triggering EHF-dependent activation of Akt/NF-kappaB signaling pathway.
      Title: Pancreatic cancer cell-derived microRNA-155-5p-containing extracellular vesicles promote immune evasion by triggering EHF-dependent activation of Akt/NF-κB signaling pathway.
    4. EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in nonsmall cell lung cancer cells.
      Title: EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in non‑small cell lung cancer cells.
    5. Loss of EHF facilitates the development of treatment-induced neuroendocrine prostate cancer.
      Title: Loss of EHF facilitates the development of treatment-induced neuroendocrine prostate cancer.
    6. Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1.
      Title: Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1.
    7. Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer.
      Title: Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer.
    8. Expression and prognostic significance of epithelial tissue-specific transcription factor ESE3 in hepatocellular carcinoma.
      Title: Expression and prognostic significance of epithelial tissue-specific transcription factor ESE3 in hepatocellular carcinoma.
    9. Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region.
      Title: Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region.
    10. Tumoral EHF expression associates with the immune profile in human pancreatic ductal adenocarcinoma patients.EHF suppressed the transcription of TGFB1 and CSF2 by directly binding to their promoters.
      Title: Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
    EBI GWAS Catalog
    Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
    EBI GWAS Catalog
    Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
    EBI GWAS Catalog
    Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.
    EBI GWAS Catalog
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog
    GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endothelial tube formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    ETS homologous factor
    Names
    ESE3 transcription factor
    ETS domain-containing transcription factor
    epithelium-specific Ets transcription factor 3
    hEHF

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029177.2 RefSeqGene

      Range
      5002..47197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206615.2 → NP_001193544.1  ETS homologous factor isoform 3

      See identical proteins and their annotated locations for NP_001193544.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an internal segment compared to isoform 1. Variants 3 and 11 both encode the same isoform (3).
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS55753.1
      UniProtKB/TrEMBL
      A0ACI8SGU0
      Related
      ENSP00000399733.2, ENST00000450654.6
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:183 → 270
      ETS; erythroblast transformation specific domain

    2. NM_001206616.2 → NP_001193545.1  ETS homologous factor isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS55752.1
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000435835.1, ENST00000531794.5
      Conserved Domains (2) summary
      cd08539
      Location:61 → 138
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:228 → 315
      ETS; erythroblast transformation specific domain

    3. NM_001378041.1 → NP_001364970.1  ETS homologous factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 2 and 5-10, encodes isoform 2.
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS7894.1
      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000577244.1, ENST00000907185.1
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    4. NM_001378042.1 → NP_001364971.1  ETS homologous factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 2, 4, and 6-10, encodes isoform 2.
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS7894.1
      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000577247.1, ENST00000907188.1
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    5. NM_001378043.1 → NP_001364972.1  ETS homologous factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 2, 4, 5, and 7-10, encodes isoform 2.
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS7894.1
      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000577249.1, ENST00000907190.1
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    6. NM_001378044.1 → NP_001364973.1  ETS homologous factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 2, 4-6, and 8-10, encodes isoform 2.
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS7894.1
      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000433508.1, ENST00000530286.5
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    7. NM_001378045.1 → NP_001364974.1  ETS homologous factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 2, 4-8, and 10, encodes isoform 2.
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS7894.1
      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000577259.1, ENST00000907200.1
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    8. NM_001378046.1 → NP_001364975.1  ETS homologous factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 2 and 4-9, encodes isoform 2.
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS7894.1
      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    9. NM_001378047.1 → NP_001364976.1  ETS homologous factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 2, 4-7, 9, and 10, encodes isoform 2.
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS7894.1
      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    10. NM_001378048.1 → NP_001364977.1  ETS homologous factor isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 3, encodes isoform 3.
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS55753.1
      UniProtKB/TrEMBL
      A0ACI8SGU0
      Related
      ENSP00000577262.1, ENST00000907203.1
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:183 → 270
      ETS; erythroblast transformation specific domain

    11. NM_001378049.1 → NP_001364978.1  ETS homologous factor isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform 4.
      Source sequence(s)
      AC087783
      UniProtKB/TrEMBL
      A0ACI8R3R4, A0ACI8RIJ5
      Related
      ENSP00000577242.1, ENST00000907183.1
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:205 → 292
      ETS; erythroblast transformation specific domain

    12. NM_001378050.1 → NP_001364979.1  ETS homologous factor isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform 4.
      Source sequence(s)
      AC087783
      UniProtKB/TrEMBL
      A0ACI8R3R4, A0ACI8RIJ5
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:205 → 292
      ETS; erythroblast transformation specific domain

    13. NM_001378051.1 → NP_001364980.1  ETS homologous factor isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform 4.
      Source sequence(s)
      AC087783
      UniProtKB/TrEMBL
      A0ACI8R3R4, A0ACI8RIJ5
      Related
      ENSP00000577268.1, ENST00000907209.1
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:205 → 292
      ETS; erythroblast transformation specific domain

    14. NM_001378052.1 → NP_001364981.1  ETS homologous factor isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC087783
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Conserved Domains (2) summary
      cd08539
      Location:61 → 138
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:227 → 314
      ETS; erythroblast transformation specific domain

    15. NM_001378053.1 → NP_001364982.1  ETS homologous factor isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC087783
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Conserved Domains (2) summary
      cd08539
      Location:42 → 119
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:209 → 296
      ETS; erythroblast transformation specific domain

    16. NM_001378054.1 → NP_001364983.1  ETS homologous factor isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC087783
      UniProtKB/TrEMBL
      A0ACI8R3M9, A0ACI8SGU0
      Related
      ENSP00000577243.1, ENST00000907184.1
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:182 → 269
      ETS; erythroblast transformation specific domain

    17. NM_001378055.1 → NP_001364984.1  ETS homologous factor isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC087783
      UniProtKB/TrEMBL
      A0ACI8SGU0
      Conserved Domains (2) summary
      cd08539
      Location:42 → 119
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:186 → 273
      ETS; erythroblast transformation specific domain

    18. NM_001378056.1 → NP_001364985.1  ETS homologous factor isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC087783
      Conserved Domains (2) summary
      smart00413
      Location:119 → 206
      ETS; erythroblast transformation specific domain
      cl15755
      Location:1 → 29
      SAM_superfamily; SAM (Sterile alpha motif )

    19. NM_012153.6 → NP_036285.2  ETS homologous factor isoform 2

      See identical proteins and their annotated locations for NP_036285.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 4-10 all encode the same isoform (2).
      Source sequence(s)
      AC087783
      Consensus CDS
      CCDS7894.1
      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000257831.3, ENST00000257831.8
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    RNA

    1. NR_165390.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087783

    2. NR_165391.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC087783

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      34621093..34663288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426759.1 → XP_047282715.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4

    2. XM_047426758.1 → XP_047282714.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000435837.1, ENST00000533754.5

    3. XM_047426755.1 → XP_047282711.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000577264.1, ENST00000907205.1

    4. XM_047426756.1 → XP_047282712.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000577260.1, ENST00000907201.1

    5. XM_047426761.1 → XP_047282717.1  ETS homologous factor isoform X2

      UniProtKB/TrEMBL
      A0ACI8R3R4, A0ACI8RIJ5
      Related
      ENSP00000577269.1, ENST00000907210.1

    6. XM_047426762.1 → XP_047282718.1  ETS homologous factor isoform X4

      UniProtKB/TrEMBL
      A0ACI8SGU0
      Related
      ENSP00000577270.1, ENST00000907211.1

    7. XM_047426754.1 → XP_047282710.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000577257.1, ENST00000907198.1

    8. XM_047426760.1 → XP_047282716.1  ETS homologous factor isoform X2

      UniProtKB/TrEMBL
      A0ACI8R3R4, A0ACI8RIJ5
      Related
      ENSP00000621118.1, ENST00000951059.1

    9. XM_047426753.1 → XP_047282709.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Related
      ENSP00000577271.1, ENST00000907212.1

    10. XM_047426757.1 → XP_047282713.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4

    11. XM_005252861.2 → XP_005252918.1  ETS homologous factor isoform X3

      UniProtKB/TrEMBL
      A0ACI8SGU0
      Conserved Domains (2) summary
      cd08539
      Location:61 → 138
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:205 → 292
      ETS; erythroblast transformation specific domain

    12. XM_024448434.2 → XP_024304202.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
      Conserved Domains (2) summary
      cd08539
      Location:39 → 116
      SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
      smart00413
      Location:206 → 293
      ETS; erythroblast transformation specific domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      34757923..34800105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368403.1 → XP_054224378.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4

    2. XM_054368402.1 → XP_054224377.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4

    3. XM_054368399.1 → XP_054224374.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4

    4. XM_054368400.1 → XP_054224375.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4

    5. XM_054368406.1 → XP_054224381.1  ETS homologous factor isoform X2

      UniProtKB/TrEMBL
      A0ACI8R3R4, A0ACI8RIJ5

    6. XM_054368408.1 → XP_054224383.1  ETS homologous factor isoform X4

      UniProtKB/TrEMBL
      A0ACI8SGU0

    7. XM_054368398.1 → XP_054224373.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4

    8. XM_054368405.1 → XP_054224380.1  ETS homologous factor isoform X2

      UniProtKB/TrEMBL
      A0ACI8R3R4, A0ACI8RIJ5

    9. XM_054368397.1 → XP_054224372.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4

    10. XM_054368401.1 → XP_054224376.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4

    11. XM_054368407.1 → XP_054224382.1  ETS homologous factor isoform X3

      UniProtKB/TrEMBL
      A0ACI8SGU0

    12. XM_054368404.1 → XP_054224379.1  ETS homologous factor isoform X1

      UniProtKB/Swiss-Prot
      D3DR08, D3DR10, E9PSB2, Q9H509, Q9NZC4, Q9UKF9, Q9Y5V4, Q9Y5V5
      UniProtKB/TrEMBL
      A0ACI8R3R4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NZC4.1 GenPept UniProtKB/Swiss-Prot:Q9NZC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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