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    CALD1 caldesmon 1 [ Homo sapiens (human) ]

    Gene ID: 800, updated on 19-May-2026
    Official Symbol
    CALD1provided by HGNC
    Official Full Name
    caldesmon 1provided by HGNC
    Primary source
    HGNC:HGNC:1441
    See related
    Ensembl:ENSG00000122786 MIM:114213; AllianceGenome:HGNC:1441
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDM; HCAD; LCAD; h-CD; H-CAD; L-CAD; NAG22
    Summary
    This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 170.6), prostate (RPKM 164.0) and 23 other tissues See more
    Orthologs
    Try the new Gene page
    Try the new Transcripts and proteins table
    See CALD1 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (134711499..134970729)
    RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136019140..136278520)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134464385..134655480)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26690 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134247191-134248390 Neighboring gene aldo-keto reductase family 1 member B15 Neighboring gene uncharacterized LOC124901750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26691 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26693 Neighboring gene Sharpr-MPRA regulatory region 13526 Neighboring gene Sharpr-MPRA regulatory region 7726 Neighboring gene Sharpr-MPRA regulatory region 6861 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134388514-134388724 Neighboring gene bisphosphoglycerate mutase Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:134426881-134427534 Neighboring gene tubulin beta 3 class III pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:134469373-134469873 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134529756-134530955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18675 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134622660-134622865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26695 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26700 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26701 Neighboring gene AGBL carboxypeptidase 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:134760279-134760886 Neighboring gene MPRA-validated peak6750 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26704 Neighboring gene cell cycle regulator of NHEJ Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26706 Neighboring gene RNF14 pseudogene 4 Neighboring gene transmembrane protein 140

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    EBI GWAS Catalog

    Description
    Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
    EBI GWAS Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Clone Names

    • MGC21352

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables myosin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tropomyosin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in myofibril IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    caldesmon
    Names
    testis secretory sperm-binding protein Li 227n

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029186.2 RefSeqGene

      Range
      39169..230264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001438765.1NP_001425694.1  caldesmon isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      Related
      ENSP00000536482.1, ENST00000866423.1
    2. NM_001438766.1NP_001425695.1  caldesmon isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC083870
    3. NM_001438767.1NP_001425696.1  caldesmon isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      B4DPW5
    4. NM_001438768.1NP_001425697.1  caldesmon isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC083870
      UniProtKB/TrEMBL
      B7Z6G4
    5. NM_001438769.1NP_001425698.1  caldesmon isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC083870, AC083874
      UniProtKB/TrEMBL
      B7Z6G4
    6. NM_001438770.1NP_001425699.1  caldesmon isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC083870, AC083874
      UniProtKB/TrEMBL
      B7Z6G4
    7. NM_001438771.1NP_001425700.1  caldesmon isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      B7Z6G4
      Related
      ENSP00000536480.1, ENST00000866421.1
    8. NM_001438772.1NP_001425701.1  caldesmon isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC083870
      UniProtKB/TrEMBL
      B7Z6G4, E7EX44
      Related
      ENSP00000419673.1, ENST00000495522.1
    9. NM_001438773.1NP_001425702.1  caldesmon isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      B7Z6G4
    10. NM_001438774.1NP_001425703.1  caldesmon isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      B7Z6G4
    11. NM_001438775.1NP_001425704.1  caldesmon isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC083870
      UniProtKB/TrEMBL
      B7Z6G4
    12. NM_001438776.1NP_001425705.1  caldesmon isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC083870
      UniProtKB/TrEMBL
      B7Z6G4
    13. NM_001438777.1NP_001425706.1  caldesmon isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      B7Z6G4
      Related
      ENSP00000536483.1, ENST00000866424.1
    14. NM_001438778.1NP_001425707.1  caldesmon isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC083870, AC083874
      UniProtKB/TrEMBL
      A0A140VKA0, B7Z6G4
      Related
      ENSP00000642482.1, ENST00000972423.1
    15. NM_001438779.1NP_001425708.1  caldesmon isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC083870, AC083874
      UniProtKB/TrEMBL
      A0A140VKA0, B7Z6G4
    16. NM_001438780.1NP_001425709.1  caldesmon isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      A0A140VKA0, B7Z6G4
    17. NM_001438781.1NP_001425710.1  caldesmon isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      A0A140VKA0, B7Z6G4
      Related
      ENSP00000597626.1, ENST00000927567.1
    18. NM_001438782.1NP_001425711.1  caldesmon isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      A0A140VKA0, B7Z6G4
    19. NM_001438783.1NP_001425712.1  caldesmon isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      A0A140VKA0, B7Z6G4
    20. NM_001438784.1NP_001425713.1  caldesmon isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      B7Z6G4
      Related
      ENSP00000536479.1, ENST00000866420.1
    21. NM_001438785.1NP_001425714.1  caldesmon isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      B7Z6G4
      Related
      ENSP00000536484.1, ENST00000866425.1
    22. NM_001438786.1NP_001425715.1  caldesmon isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC083870
      UniProtKB/TrEMBL
      B7Z6G4
    23. NM_001438787.1NP_001425716.1  caldesmon isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC083870
      UniProtKB/TrEMBL
      B7Z6G4
    24. NM_001438788.1NP_001425717.1  caldesmon isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
      UniProtKB/TrEMBL
      B7Z6G4
      Related
      ENSP00000536481.1, ENST00000866422.1
    25. NM_001438789.1NP_001425718.1  caldesmon isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC083870
      UniProtKB/TrEMBL
      B7Z6G4
    26. NM_004342.7NP_004333.1  caldesmon isoform 2

      See identical proteins and their annotated locations for NP_004333.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1. It is mainly expressed in non-muscle tissues or cells. The resulting isoform (2, also known as WI-38 l-CaD II) lacks an internal region, compared to isoform 1.
      Source sequence(s)
      AU134367, BC040354, CA447404, CN314587, CV573441, DA546174, DB090561
      Consensus CDS
      CCDS5834.1
      UniProtKB/TrEMBL
      A0A140VKA0, B7Z6G4
      Related
      ENSP00000354513.2, ENST00000361901.6
      Conserved Domains (1) summary
      pfam02029
      Location:267525
      Caldesmon; Caldesmon
    27. NM_033138.4NP_149129.2  caldesmon isoform 1

      See identical proteins and their annotated locations for NP_149129.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1, also known as aorta h-CaD). It is predominantly expressed in smooth muscle tissues.
      Source sequence(s)
      AC083870, AU134367, CA447404, CN314587, CV573441, DA546174, DB090561, M83216
      Consensus CDS
      CCDS5835.1
      UniProtKB/Swiss-Prot
      A8K0X1, Q05682, Q13978, Q13979, Q14741, Q14742, Q9UD91
      Related
      ENSP00000354826.2, ENST00000361675.7
      Conserved Domains (1) summary
      pfam02029
      Location:517780
      Caldesmon; Caldesmon
    28. NM_033139.4NP_149130.1  caldesmon isoform 4

      See identical proteins and their annotated locations for NP_149130.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. It is mainly expressed in non-muscle tissues or cells. The resulting isoform (4, also known as HeLa l-CaD I) contains a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC083870, AU134367, CA447404, CK821334, CN314587, CV573441, D90452, DA323544, DA546174
      Consensus CDS
      CCDS47716.1
      UniProtKB/TrEMBL
      B7Z6G4
      Related
      ENSP00000376826.2, ENST00000393118.7
      Conserved Domains (1) summary
      pfam02029
      Location:282545
      Caldesmon; Caldesmon
    29. NM_033140.4NP_149131.1  caldesmon isoform 5

      See identical proteins and their annotated locations for NP_149131.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, and uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1. It is mainly expressed in non-muscle tissues or cells. The resulting isoform (5, also known as HeLa l-CaD II) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC083870, AU134367, CA447404, CK821334, CN314587, CV573441, D90453, DA323544, DA546174
      Consensus CDS
      CCDS47717.1
      UniProtKB/TrEMBL
      B7Z6G4
      Related
      ENSP00000393621.1, ENST00000424922.5
      Conserved Domains (1) summary
      pfam02029
      Location:256519
      Caldesmon; Caldesmon
    30. NM_033157.4NP_149347.2  caldesmon isoform 3

      See identical proteins and their annotated locations for NP_149347.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1. It is mainly expressed in non-muscle tissues or cells. The resulting isoform (3, also known as WI-38 l-CaD I) is shorter than isoform 1.
      Source sequence(s)
      AK289686, AU134367, CA447404, CN314587, CV573441, DA546174
      Consensus CDS
      CCDS5836.2
      UniProtKB/TrEMBL
      B7Z6G4
      Related
      ENSP00000395710.1, ENST00000422748.5
      Conserved Domains (1) summary
      pfam02029
      Location:288550
      Caldesmon; Caldesmon

    RNA

    1. NR_199386.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC019014, AC083870
    2. NR_199387.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC083870
      Related
      ENST00000443197.5
    3. NR_199388.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC083870
    4. NR_199389.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC083870

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      134711499..134970729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420865.1XP_047276821.1  caldesmon isoform X7

      UniProtKB/TrEMBL
      B7Z6G4
      Related
      ENSP00000642465.1, ENST00000972406.1
    2. XM_047420867.1XP_047276823.1  caldesmon isoform X8

      UniProtKB/TrEMBL
      B7Z6G4
      Related
      ENSP00000536478.1, ENST00000866419.1
    3. XM_047420859.1XP_047276815.1  caldesmon isoform X1

    4. XM_047420871.1XP_047276827.1  caldesmon isoform X11

      UniProtKB/TrEMBL
      E9PGZ1
      Related
      ENSP00000411476.2, ENST00000436461.6
    5. XM_047420858.1XP_047276814.1  caldesmon isoform X1

    6. XM_047420861.1XP_047276817.1  caldesmon isoform X2

    7. XM_047420864.1XP_047276820.1  caldesmon isoform X6

      UniProtKB/TrEMBL
      E9PGZ1
    8. XM_047420873.1XP_047276829.1  caldesmon isoform X12

      UniProtKB/TrEMBL
      E9PGZ1
    9. XM_047420866.1XP_047276822.1  caldesmon isoform X7

      UniProtKB/TrEMBL
      B7Z6G4
    10. XM_017012652.2XP_016868141.1  caldesmon isoform X13

      UniProtKB/TrEMBL
      A0A140VKA0, B7Z6G4
      Related
      ENSP00000536487.1, ENST00000866428.1
      Conserved Domains (1) summary
      pfam02029
      Location:267525
      Caldesmon; Caldesmon
    11. XM_047420876.1XP_047276832.1  caldesmon isoform X14

      UniProtKB/TrEMBL
      B7Z6G4
    12. XM_047420860.1XP_047276816.1  caldesmon isoform X1

    13. XM_047420872.1XP_047276828.1  caldesmon isoform X11

      UniProtKB/TrEMBL
      E9PGZ1
    14. XM_047420862.1XP_047276818.1  caldesmon isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      136019140..136278520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359065.1XP_054215040.1  caldesmon isoform X7

      UniProtKB/TrEMBL
      B7Z6G4
    2. XM_054359067.1XP_054215042.1  caldesmon isoform X8

      UniProtKB/TrEMBL
      B7Z6G4
    3. XM_054359057.1XP_054215032.1  caldesmon isoform X1

    4. XM_054359071.1XP_054215046.1  caldesmon isoform X11

      UniProtKB/TrEMBL
      E9PGZ1
    5. XM_054359056.1XP_054215031.1  caldesmon isoform X1

    6. XM_054359059.1XP_054215034.1  caldesmon isoform X2

    7. XM_054359063.1XP_054215038.1  caldesmon isoform X6

      UniProtKB/TrEMBL
      E9PGZ1
    8. XM_054359073.1XP_054215048.1  caldesmon isoform X12

      UniProtKB/TrEMBL
      E9PGZ1
    9. XM_054359075.1XP_054215050.1  caldesmon isoform X13

      UniProtKB/TrEMBL
      A0A140VKA0, B7Z6G4
    10. XM_054359066.1XP_054215041.1  caldesmon isoform X7

      UniProtKB/TrEMBL
      B7Z6G4
    11. XM_054359078.1XP_054215053.1  caldesmon isoform X14

      UniProtKB/TrEMBL
      B7Z6G4
    12. XM_054359058.1XP_054215033.1  caldesmon isoform X1

    13. XM_054359072.1XP_054215047.1  caldesmon isoform X11

      UniProtKB/TrEMBL
      E9PGZ1
    14. XM_054359061.1XP_054215036.1  caldesmon isoform X4