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    ADGRL2 adhesion G protein-coupled receptor L2 [ Homo sapiens (human) ]

    Gene ID: 23266, updated on 5-Aug-2026
    Official Symbol
    ADGRL2provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor L2provided by HGNC
    Primary source
    HGNC:HGNC:18582
    See related
    Ensembl:ENSG00000117114 MIM:607018; AllianceGenome:HGNC:18582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CL2; LEC1; CIRL2; LPHH1; LPHN2
    Summary
    This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 16.1), lung (RPKM 14.8) and 23 other tissues See more
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See ADGRL2 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (81306132..81993932)
    RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (81143677..81831513)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (81771817..82459616)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985018 Neighboring gene NANOG hESC enhancer GRCh37_chr1:81771994-81772586 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:81777641-81778142 Neighboring gene RN7SK pseudogene 247 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:81778143-81778642 Neighboring gene Sharpr-MPRA regulatory region 14351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1240 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:81923876-81924376 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 14 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:81935555-81936062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:81936063-81936570 Neighboring gene Sharpr-MPRA regulatory region 8606 Neighboring gene uncharacterized LOC101927434 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:82009398-82010005 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:82013019-82013798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1007 Neighboring gene ARID3B pseudogene 1 Neighboring gene mediator complex subunit 28 pseudogene 8 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:82147966-82148534 Neighboring gene ribosomal protein S20 pseudogene 7 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:82269743-82270385 Neighboring gene ST13, Hsp70 interacting protein pseudogene 20 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:82314353-82315135 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:82533259-82533822 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_9174 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:82601932-82602446 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:82602447-82602960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:82716029-82716528 Neighboring gene uncharacterized LOC124904204 Neighboring gene uncharacterized LOC105378814

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Related articles in PubMed

    1. Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-Specific Biomarker for Human Gastrointestinal Cancer. Jeon MS, et al. Cancer Res Treat, 2016 Apr. PMID 26511811, Free PMC Article
    2. Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines. White GR, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760572
    3. Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. White GR, et al. Oncogene, 1998 Dec 31. PMID 10030676
    4. N-glycans of Phaeodactylum tricornutum diatom and functional characterization of its N-acetylglucosaminyltransferase I enzyme. Baïet B, et al. J Biol Chem, 2011 Feb 25. PMID 21169367, Free PMC Article
    5. CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630. Zhang Y, et al. Aging (Albany NY), 2017 Jun 27. PMID 28657541, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions.
      Title: Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions.
    2. Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK.
      Title: Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK.
    3. LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion.
      Title: LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion.
    4. The results of this study suggest that this ADGRL2 variation impedes the proper development of the cerebellum resulting in RES which is thought to occur when the cerebellar primordium develops and probably results from abnormal function of genes expressed during initial patterning of the mesencephalon-rhombencephalon
      Title: A de novo variant in ADGRL2 suggests a novel mechanism underlying the previously undescribed association of extreme microcephaly with severely reduced sulcation and rhombencephalosynapsis.
    Submit: New GeneRIF Correction

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
    EBI GWAS Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog
    UGT1A1 is a major locus influencing bilirubin levels in African Americans.
    EBI GWAS Catalog

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables latrotoxin receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in excitatory synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Preferred Names
    adhesion G protein-coupled receptor L2
    Names
    calcium-independent alpha-latrotoxin receptor 2
    latrophilin homolog 1
    latrophilin-2
    lectomedin-1

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297704.3 → NP_001284633.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001284633.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4. Variants 1, 2, 8, 18, and 19 all encode the same isoform (1).
      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS689.1
      UniProtKB/TrEMBL
      A0ACI8TBW7
      Related
      ENSP00000353006.2, ENST00000359929.8
      Conserved Domains (7) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      cd16006
      Location:831 → 1088
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1403
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 747
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    2. NM_001297705.3 → NP_001284634.1  adhesion G protein-coupled receptor L2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001284634.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and contains two alternate exons in the 3' coding region, which results in a frameshift, compared to variant 5. The encoded isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 4.
      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS72811.1
      UniProtKB/TrEMBL
      A0A6I8PRQ0
      Related
      ENSP00000359750.1, ENST00000370715.6
      Conserved Domains (7) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam00002
      Location:832 → 1067
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1162
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:539 → 745
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    3. NM_001297706.3 → NP_001284635.1  adhesion G protein-coupled receptor L2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001284635.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons compared to variant 5. The encoded isoform (3) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 4.
      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS76174.1
      UniProtKB/TrEMBL
      A0A6I8PRQ0
      Related
      ENSP00000359748.1, ENST00000370713.6
      Conserved Domains (7) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam00002
      Location:832 → 1067
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1120
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:539 → 745
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    4. NM_001330645.3 → NP_001317574.1  adhesion G protein-coupled receptor L2 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 17, encodes isoform 4.
      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS81345.1
      UniProtKB/TrEMBL
      B1ALU3
      Related
      ENSP00000501462.1, ENST00000674419.2
      Conserved Domains (7) summary
      smart00303
      Location:784 → 836
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      cd16006
      Location:844 → 1101
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1100 → 1416
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    5. NM_001350698.2 → NP_001337627.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 9, 10, and 16, encodes isoform 5.
      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0ACI8U4F3, A0ACI8U7B8
      Related
      ENSP00000611401.1, ENST00000941342.2
      Conserved Domains (7) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      cd16006
      Location:848 → 1105
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1104 → 1463
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    6. NM_001350699.2 → NP_001337628.1  adhesion G protein-coupled receptor L2 isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 21, encodes isoform 6.
      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS90990.1
      UniProtKB/TrEMBL
      A0A6I8PIV6, A0A6I8PRQ0
      Related
      ENSP00000501484.1, ENST00000674442.2
      Conserved Domains (8) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1162
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 747
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:833 → 858
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain
      cl28897
      Location:831 → 1088
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. NM_001366002.2 → NP_001352931.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 2, 18, and 19, encodes isoform 1.
      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS689.1
      UniProtKB/TrEMBL
      A0ACI8TBW7
      Related
      ENSP00000501431.1, ENST00000674393.2
      Conserved Domains (7) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      cd16006
      Location:831 → 1088
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1403
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 747
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    8. NM_001366003.2 → NP_001352932.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 6, 10 and 16, encodes isoform 5.
      Source sequence(s)
      AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0ACI8U4F3, A0ACI8U7B8
      Conserved Domains (7) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      cd16006
      Location:848 → 1105
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1104 → 1463
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    9. NM_001366004.2 → NP_001352933.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 6, 9, and 16, encodes isoform 5.
      Source sequence(s)
      AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0ACI8U4F3, A0ACI8U7B8
      Conserved Domains (7) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      cd16006
      Location:848 → 1105
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1104 → 1463
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    10. NM_001366005.2 → NP_001352934.1  adhesion G protein-coupled receptor L2 isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 12, encodes isoform 7.
      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS90986.1
      UniProtKB/TrEMBL
      A0A8I5KUX3, A0ACI8U7B8
      Conserved Domains (7) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1104 → 1469
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd16006
      Location:848 → 1105
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    11. NM_001366006.2 → NP_001352935.1  adhesion G protein-coupled receptor L2 isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variant 11, encodes isoform 7.
      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS90986.1
      UniProtKB/TrEMBL
      A0A8I5KUX3, A0ACI8U7B8
      Related
      ENSP00000509478.1, ENST00000686636.1
      Conserved Domains (7) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1104 → 1469
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd16006
      Location:848 → 1105
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    12. NM_001366007.2 → NP_001352936.1  adhesion G protein-coupled receptor L2 isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0A6I8PRQ0
      Related
      ENSP00000501543.1, ENST00000674489.2
      Conserved Domains (8) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1119 → 1227
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd16006
      Location:851 → 875
      7tmB2_Latrophilin-2; TM helix 1 [structural motif]
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain
      cl28897
      Location:848 → 1120
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    13. NM_001366008.2 → NP_001352937.1  adhesion G protein-coupled receptor L2 isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0A6I8PRQ0
      Conserved Domains (7) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1104 → 1212
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd16006
      Location:848 → 1105
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    14. NM_001366009.2 → NP_001352938.1  adhesion G protein-coupled receptor L2 isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS90988.1
      UniProtKB/TrEMBL
      A0A6I8PLG0, A0A6I8PRQ0
      Related
      ENSP00000501532.1, ENST00000674208.2
      Conserved Domains (8) summary
      smart00303
      Location:784 → 836
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1100 → 1175
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:847 → 871
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain
      cl28897
      Location:844 → 1101
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    15. NM_001393349.1 → NP_001380278.1  adhesion G protein-coupled receptor L2 isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC093154, AC095035, AC113949, AL138799, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0ACI8U4F3, A0ACI8U7B8
      Related
      ENSP00000359760.1, ENST00000370725.6
      Conserved Domains (7) summary
      smart00303
      Location:788 → 840
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:469 → 533
      HormR; Domain present in hormone receptors
      cd16006
      Location:848 → 1105
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1104 → 1463
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:542 → 764
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:142 → 398
      OLF; Olfactomedin-like domain

    16. NM_001393350.1 → NP_001380279.1  adhesion G protein-coupled receptor L2 isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS81345.1
      UniProtKB/TrEMBL
      B1ALU3
      Related
      ENSP00000525627.1, ENST00000855568.2
      Conserved Domains (7) summary
      smart00303
      Location:784 → 836
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      cd16006
      Location:844 → 1101
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1100 → 1416
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    17. NM_001393351.1 → NP_001380280.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS689.1
      UniProtKB/TrEMBL
      A0ACI8TBW7
      Related
      ENSP00000596559.1, ENST00000926500.2
      Conserved Domains (7) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      cd16006
      Location:831 → 1088
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1403
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 747
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    18. NM_001393352.1 → NP_001380281.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS689.1
      UniProtKB/TrEMBL
      A0ACI8TBW7
      Related
      ENSP00000525629.1, ENST00000855570.2
      Conserved Domains (7) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      cd16006
      Location:831 → 1088
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1403
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 747
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    19. NM_001393353.1 → NP_001380282.1  adhesion G protein-coupled receptor L2 isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0A6I8PRQ0
      Related
      ENSP00000648987.1, ENST00000979170.1
      Conserved Domains (8) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1162
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 747
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:833 → 858
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain
      cl28897
      Location:831 → 1088
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    20. NM_001393354.1 → NP_001380283.1  adhesion G protein-coupled receptor L2 isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS90990.1
      UniProtKB/TrEMBL
      A0A6I8PIV6, A0A6I8PRQ0
      Related
      ENSP00000648988.1, ENST00000979171.1
      Conserved Domains (8) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1162
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 747
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd14964
      Location:833 → 858
      7tm_GPCRs; TM helix 1 [structural motif]
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain
      cl28897
      Location:831 → 1088
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    21. NM_001437665.1 → NP_001424594.1  adhesion G protein-coupled receptor L2 isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2
      Related
      ENSP00000596562.1, ENST00000926503.2

    22. NM_001437666.1 → NP_001424595.1  adhesion G protein-coupled receptor L2 isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2

    23. NM_001437667.1 → NP_001424596.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0ACI8TBW7
      Related
      ENSP00000525625.1, ENST00000855566.2

    24. NM_001437668.1 → NP_001424597.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0ACI8TBW7
      Related
      ENSP00000525634.1, ENST00000855575.2

    25. NM_001437669.1 → NP_001424598.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0ACI8TBW7
      Related
      ENSP00000525630.1, ENST00000855571.2

    26. NM_001437670.1 → NP_001424599.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      UniProtKB/TrEMBL
      A0ACI8TBW7
      Related
      ENSP00000525635.1, ENST00000855576.2

    27. NM_001437671.1 → NP_001424600.1  adhesion G protein-coupled receptor L2 isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Related
      ENSP00000784725.1, ENST00001114920.1

    28. NM_001437672.1 → NP_001424601.1  adhesion G protein-coupled receptor L2 isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      UniProtKB/Swiss-Prot
      A5XEI2, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6
      UniProtKB/TrEMBL
      A0ACI8U7B8
      Related
      ENSP00000397740.1, ENST00000449420.5

    29. NM_012302.5 → NP_036434.1  adhesion G protein-coupled receptor L2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_036434.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4. Variants 1, 2, 8, 18, and 19 all encode the same isoform (1).
      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705
      Consensus CDS
      CCDS689.1
      UniProtKB/TrEMBL
      A0ACI8TBW7
      Related
      ENSP00000322270.6, ENST00000319517.11
      Conserved Domains (7) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      cd16006
      Location:831 → 1088
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1403
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 747
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    RNA

    1. NR_171658.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC113949, AL157903, AL358939, AL359705

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      81306132..81993932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416152.1 → XP_047272108.1  adhesion G protein-coupled receptor L2 isoform X6

      UniProtKB/TrEMBL
      A0A6I8PLG0, A0A6I8PRQ0

    2. XM_047416118.1 → XP_047272074.1  adhesion G protein-coupled receptor L2 isoform X3

      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2

    3. XM_047416159.1 → XP_047272115.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0

    4. XM_047416140.1 → XP_047272096.1  adhesion G protein-coupled receptor L2 isoform X5

      UniProtKB/TrEMBL
      A0ACI8TBW7
      Related
      ENSP00000611394.1, ENST00000941335.2

    5. XM_047416096.1 → XP_047272052.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    6. XM_024454355.2 → XP_024310123.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3
      Related
      ENSP00000525624.1, ENST00000855565.2
      Conserved Domains (7) summary
      smart00303
      Location:784 → 836
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      cd16006
      Location:844 → 1101
      7tmB2_Latrophilin-2; Latrophilin-2, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1100 → 1416
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:538 → 760
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    7. XM_047416129.1 → XP_047272085.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3
      Related
      ENSP00000525628.1, ENST00000855569.2

    8. XM_047416170.1 → XP_047272126.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0
      Related
      ENSP00000648989.1, ENST00000979172.1

    9. XM_017000784.2 → XP_016856273.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8
      Conserved Domains (8) summary
      smart00303
      Location:789 → 841
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:470 → 534
      HormR; Domain present in hormone receptors
      COG1266
      Location:918 → 1092
      YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
      pfam00002
      Location:850 → 1085
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1105 → 1464
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544 → 763
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    10. XM_047416105.1 → XP_047272061.1  adhesion G protein-coupled receptor L2 isoform X2

      UniProtKB/Swiss-Prot
      A5XEI2, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6
      UniProtKB/TrEMBL
      A0ACI8U7B8
      Related
      ENSP00000359752.3, ENST00000370717.7

    11. XM_005270668.3 → XP_005270725.1  adhesion G protein-coupled receptor L2 isoform X3

      See identical proteins and their annotated locations for XP_005270725.1

      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2
      Related
      ENSP00000501324.1, ENST00000674209.2
      Conserved Domains (8) summary
      smart00303
      Location:771 → 823
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      COG1266
      Location:900 → 1074
      YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
      pfam00002
      Location:832 → 1067
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1087 → 1446
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:539 → 745
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    12. XM_047416176.1 → XP_047272132.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0
      Related
      ENSP00000648986.1, ENST00000979169.1

    13. XM_047416098.1 → XP_047272054.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    14. XM_047416104.1 → XP_047272060.1  adhesion G protein-coupled receptor L2 isoform X2

      UniProtKB/Swiss-Prot
      A5XEI2, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6
      UniProtKB/TrEMBL
      A0ACI8U7B8

    15. XM_047416132.1 → XP_047272088.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3
      Related
      ENSP00000525626.1, ENST00000855567.2

    16. XM_047416126.1 → XP_047272082.1  adhesion G protein-coupled receptor L2 isoform X3

      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2

    17. XM_047416180.1 → XP_047272136.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0

    18. XM_006710489.4 → XP_006710552.1  adhesion G protein-coupled receptor L2 isoform X1

      See identical proteins and their annotated locations for XP_006710552.1

      UniProtKB/TrEMBL
      A0ACI8U7B8
      Conserved Domains (8) summary
      smart00303
      Location:789 → 841
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:470 → 534
      HormR; Domain present in hormone receptors
      COG1266
      Location:918 → 1092
      YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
      pfam00002
      Location:850 → 1085
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1105 → 1464
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544 → 763
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    19. XM_047416115.1 → XP_047272071.1  adhesion G protein-coupled receptor L2 isoform X2

      UniProtKB/Swiss-Prot
      A5XEI2, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6
      UniProtKB/TrEMBL
      A0ACI8U7B8

    20. XM_047416156.1 → XP_047272112.1  adhesion G protein-coupled receptor L2 isoform X6

      UniProtKB/TrEMBL
      A0A6I8PLG0, A0A6I8PRQ0

    21. XM_006710488.3 → XP_006710551.1  adhesion G protein-coupled receptor L2 isoform X1

      See identical proteins and their annotated locations for XP_006710551.1

      UniProtKB/TrEMBL
      A0ACI8U7B8
      Conserved Domains (8) summary
      smart00303
      Location:789 → 841
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:470 → 534
      HormR; Domain present in hormone receptors
      COG1266
      Location:918 → 1092
      YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
      pfam00002
      Location:850 → 1085
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1105 → 1464
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544 → 763
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    22. XM_006710485.4 → XP_006710548.1  adhesion G protein-coupled receptor L2 isoform X1

      See identical proteins and their annotated locations for XP_006710548.1

      UniProtKB/TrEMBL
      A0ACI8U7B8
      Related
      ENSP00000611408.1, ENST00000941349.2
      Conserved Domains (8) summary
      smart00303
      Location:789 → 841
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:470 → 534
      HormR; Domain present in hormone receptors
      COG1266
      Location:918 → 1092
      YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
      pfam00002
      Location:850 → 1085
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1105 → 1464
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544 → 763
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143 → 399
      OLF; Olfactomedin-like domain

    23. XM_005270666.5 → XP_005270723.1  adhesion G protein-coupled receptor L2 isoform X2

      See identical proteins and their annotated locations for XP_005270723.1

      UniProtKB/Swiss-Prot
      A5XEI2, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6
      UniProtKB/TrEMBL
      A0ACI8U7B8
      Related
      ENSP00000596564.1, ENST00000926505.2
      Conserved Domains (8) summary
      smart00303
      Location:784 → 836
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:465 → 529
      HormR; Domain present in hormone receptors
      COG1266
      Location:913 → 1087
      YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
      pfam00002
      Location:845 → 1080
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:49 → 129
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:1100 → 1459
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:539 → 758
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:138 → 394
      OLF; Olfactomedin-like domain

    24. XM_047416128.1 → XP_047272084.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3
      Related
      ENSP00000525631.1, ENST00000855572.2

    25. XM_047416119.1 → XP_047272075.1  adhesion G protein-coupled receptor L2 isoform X3

      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2
      Related
      ENSP00000525633.1, ENST00000855574.2

    26. XM_047416164.1 → XP_047272120.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0
      Related
      ENSP00000648990.1, ENST00000979173.1

    27. XM_047416092.1 → XP_047272048.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    28. XM_047416109.1 → XP_047272065.1  adhesion G protein-coupled receptor L2 isoform X2

      UniProtKB/Swiss-Prot
      A5XEI2, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6
      UniProtKB/TrEMBL
      A0ACI8U7B8

    29. XM_047416130.1 → XP_047272086.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3
      Related
      ENSP00000525632.1, ENST00000855573.2

    30. XM_047416120.1 → XP_047272076.1  adhesion G protein-coupled receptor L2 isoform X3

      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2

    31. XM_047416178.1 → XP_047272134.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0

    32. XM_047416099.1 → XP_047272055.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    33. XM_047416110.1 → XP_047272066.1  adhesion G protein-coupled receptor L2 isoform X2

      UniProtKB/Swiss-Prot
      A5XEI2, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6
      UniProtKB/TrEMBL
      A0ACI8U7B8
      Related
      ENSP00000359763.1, ENST00000370728.6

    34. XM_047416136.1 → XP_047272092.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3
      Related
      ENSP00000525636.1, ENST00000855577.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      81143677..81831513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335445.1 → XP_054191420.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    2. XM_054335478.1 → XP_054191453.1  adhesion G protein-coupled receptor L2 isoform X11

      UniProtKB/TrEMBL
      A0A6I8PRQ0

    3. XM_054335464.1 → XP_054191439.1  adhesion G protein-coupled receptor L2 isoform X9

      UniProtKB/TrEMBL
      A0ACI8U7I2, B1ALU3

    4. XM_054335457.1 → XP_054191432.1  adhesion G protein-coupled receptor L2 isoform X8

      UniProtKB/TrEMBL
      A0ACI8U7B8

    5. XM_054335481.1 → XP_054191456.1  adhesion G protein-coupled receptor L2 isoform X12

      UniProtKB/TrEMBL
      A0A6I8PRQ0

    6. XM_054335471.1 → XP_054191446.1  adhesion G protein-coupled receptor L2 isoform X10

      UniProtKB/TrEMBL
      A0ACI8TBW7, A0ACI8U7H9

    7. XM_054335479.1 → XP_054191454.1  adhesion G protein-coupled receptor L2 isoform X6

      UniProtKB/TrEMBL
      A0A6I8PLG0, A0A6I8PRQ0

    8. XM_054335470.1 → XP_054191445.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3

    9. XM_054335458.1 → XP_054191433.1  adhesion G protein-coupled receptor L2 isoform X3

      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2

    10. XM_054335482.1 → XP_054191457.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0

    11. XM_054335472.1 → XP_054191447.1  adhesion G protein-coupled receptor L2 isoform X5

      UniProtKB/TrEMBL
      A0ACI8TBW7

    12. XM_054335450.1 → XP_054191425.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    13. XM_054335466.1 → XP_054191441.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3

    14. XM_054335476.1 → XP_054191451.1  adhesion G protein-coupled receptor L2 isoform X5

      UniProtKB/TrEMBL
      A0ACI8TBW7

    15. XM_054335477.1 → XP_054191452.1  adhesion G protein-coupled receptor L2 isoform X5

      UniProtKB/TrEMBL
      A0ACI8TBW7

    16. XM_054335451.1 → XP_054191426.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    17. XM_054335468.1 → XP_054191443.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3

    18. XM_054335452.1 → XP_054191427.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    19. XM_054335454.1 → XP_054191429.1  adhesion G protein-coupled receptor L2 isoform X2

      UniProtKB/Swiss-Prot
      A5XEI2, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6
      UniProtKB/TrEMBL
      A0ACI8U7B8

    20. XM_054335459.1 → XP_054191434.1  adhesion G protein-coupled receptor L2 isoform X3

      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2

    21. XM_054335485.1 → XP_054191460.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0

    22. XM_054335467.1 → XP_054191442.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3

    23. XM_054335484.1 → XP_054191459.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0

    24. XM_054335456.1 → XP_054191431.1  adhesion G protein-coupled receptor L2 isoform X2

      UniProtKB/Swiss-Prot
      A5XEI2, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6
      UniProtKB/TrEMBL
      A0ACI8U7B8

    25. XM_054335480.1 → XP_054191455.1  adhesion G protein-coupled receptor L2 isoform X6

      UniProtKB/TrEMBL
      A0A6I8PLG0, A0A6I8PRQ0

    26. XM_054335449.1 → XP_054191424.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    27. XM_054335447.1 → XP_054191422.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    28. XM_054335446.1 → XP_054191421.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    29. XM_054335448.1 → XP_054191423.1  adhesion G protein-coupled receptor L2 isoform X1

      UniProtKB/TrEMBL
      A0ACI8U7B8

    30. XM_054335455.1 → XP_054191430.1  adhesion G protein-coupled receptor L2 isoform X2

      UniProtKB/Swiss-Prot
      A5XEI2, B1ALT8, B1ALT9, B1ALU0, B1ALU2, B1ALU4, B1ALU5, B1ALU6, O94882, O95490, Q5VX76, Q9UKY5, Q9UKY6
      UniProtKB/TrEMBL
      A0ACI8U7B8

    31. XM_054335461.1 → XP_054191436.1  adhesion G protein-coupled receptor L2 isoform X3

      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2

    32. XM_054335463.1 → XP_054191438.1  adhesion G protein-coupled receptor L2 isoform X3

      UniProtKB/TrEMBL
      A0A6I8PRJ0, A0A6I8PTT2

    33. XM_054335465.1 → XP_054191440.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3

    34. XM_054335469.1 → XP_054191444.1  adhesion G protein-coupled receptor L2 isoform X4

      UniProtKB/TrEMBL
      B1ALU3

    35. XM_054335483.1 → XP_054191458.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0

    36. XM_054335486.1 → XP_054191461.1  adhesion G protein-coupled receptor L2 isoform X7

      UniProtKB/TrEMBL
      A0A6I8PRQ0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95490.2 GenPept UniProtKB/Swiss-Prot:O95490

    Gene LinkOut

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