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    Shc1 src homology 2 domain-containing transforming protein C1 [ Mus musculus (house mouse) ]

    Gene ID: 20416, updated on 8-Apr-2018
    Official Symbol
    Shc1provided by MGI
    Official Full Name
    src homology 2 domain-containing transforming protein C1provided by MGI
    Primary source
    MGI:MGI:98296
    See related
    Ensembl:ENSMUSG00000042626 Vega:OTTMUSG00000022071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Shc; p66; ShcA; p66shc
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 33.0), ovary adult (RPKM 32.1) and 28 other tissues See more
    Orthologs
    Location:
    3 F1; 3 39.11 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (89418402..89430029)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (89222473..89233951)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene CDC28 protein kinase 1b Neighboring gene pygopus 2 Neighboring gene pre B cell leukemia transcription factor interacting protein 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    neurotrophin TRKA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of MAPK activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    activation of MAPK activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation in bone marrow ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to endothelin ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Shc-EGFR complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    SHC-transforming protein 1
    Names
    SH2 domain protein C1
    SHC-transforming protein A
    Src homology 2 domain-containing transforming protein 1 isoform p66

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113331.2NP_001106802.1  SHC-transforming protein 1 isoform a

      See identical proteins and their annotated locations for NP_001106802.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK049357, BB458154, BB656759, BQ031241
      Consensus CDS
      CCDS50962.1
      UniProtKB/Swiss-Prot
      P98083
      Related
      ENSMUSP00000091940.3, OTTMUSP00000024848, ENSMUST00000094378.9, OTTMUST00000052404
      Conserved Domains (2) summary
      cd09925
      Location:476578
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:146317
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    2. NM_011368.5NP_035498.2  SHC-transforming protein 1 isoform b

      See identical proteins and their annotated locations for NP_035498.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK049357, BB458154, BQ031241, BY341731
      Consensus CDS
      CCDS17508.1
      UniProtKB/Swiss-Prot
      P98083
      Related
      ENSMUSP00000140336.1, ENSMUST00000191485.6
      Conserved Domains (2) summary
      cd09925
      Location:366468
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:36207
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      89418402..89430029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501212.3XP_006501275.1  SHC-transforming protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006501275.1

      Conserved Domains (2) summary
      cd09925
      Location:310412
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:1151
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    2. XM_006501213.2XP_006501276.1  SHC-transforming protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006501276.1

      Conserved Domains (2) summary
      cd09925
      Location:310412
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:1151
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
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