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    C6 complement component 6 [ Mus musculus (house mouse) ]

    Gene ID: 12274, updated on 7-Jan-2018

    Summary

    Official Symbol
    C6provided by MGI
    Official Full Name
    complement component 6provided by MGI
    Primary source
    MGI:MGI:88233
    See related
    Ensembl:ENSMUSG00000022181 Vega:OTTMUSG00000032527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW111623
    Expression
    Biased expression in lung adult (RPKM 5.0), subcutaneous fat pad adult (RPKM 4.2) and 11 other tissues See more
    Orthologs

    Genomic context

    Location:
    15 A1; 15 1.97 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (4727067..4804045)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (4677210..4754045)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene cDNA Sequence BC037032 Neighboring gene 3-oxoacid CoA transferase 1 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene maestro heat-like repeat family member 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of activation of membrane attack complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of complement activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane attack complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016704.2NP_057913.2  complement component C6 precursor

      See identical proteins and their annotated locations for NP_057913.2

      Status: VALIDATED

      Source sequence(s)
      AA212862, AC117588, BB222000, BX515704, BY088427, BY105449, CB948485
      Consensus CDS
      CCDS37025.1
      UniProtKB/TrEMBL
      Q91X70
      Related
      ENSMUSP00000124417.1, OTTMUSP00000043171, ENSMUST00000162585.7, OTTMUST00000080935
      Conserved Domains (5) summary
      cd00033
      Location:644700
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00209
      Location:568614
      TSP1; Thrombospondin type 1 repeats
      smart00457
      Location:313514
      MACPF; membrane-attack complex / perforin
      cd00112
      Location:142173
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl15278
      Location:85128
      TSP_1; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      4727067..4804045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519959.3XP_006520022.1  complement component C6 isoform X2

      Conserved Domains (4) summary
      smart00209
      Location:2679
      TSP1; Thrombospondin type 1 repeats
      cd00112
      Location:142173
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl02616
      Location:313429
      MACPF; MAC/Perforin domain
      cl15278
      Location:85133
      TSP_1; Thrombospondin type 1 domain
    2. XM_006519958.1XP_006520021.1  complement component C6 isoform X1

      See identical proteins and their annotated locations for XP_006520021.1

      Conserved Domains (5) summary
      cd00033
      Location:644700
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00209
      Location:568614
      TSP1; Thrombospondin type 1 repeats
      smart00457
      Location:313514
      MACPF; membrane-attack complex / perforin
      cd00112
      Location:142173
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl15278
      Location:85133
      TSP_1; Thrombospondin type 1 domain
    3. XM_006519957.3XP_006520020.1  complement component C6 isoform X1

      See identical proteins and their annotated locations for XP_006520020.1

      Conserved Domains (5) summary
      cd00033
      Location:644700
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00209
      Location:568614
      TSP1; Thrombospondin type 1 repeats
      smart00457
      Location:313514
      MACPF; membrane-attack complex / perforin
      cd00112
      Location:142173
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl15278
      Location:85133
      TSP_1; Thrombospondin type 1 domain
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