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    BNIP3L BCL2 interacting protein 3 like [ Homo sapiens (human) ]

    Gene ID: 665, updated on 17-Jun-2019

    Summary

    Official Symbol
    BNIP3Lprovided by HGNC
    Official Full Name
    BCL2 interacting protein 3 likeprovided by HGNC
    Primary source
    HGNC:HGNC:1085
    See related
    Ensembl:ENSG00000104765 MIM:605368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NIX; BNIP3a
    Summary
    This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
    Expression
    Ubiquitous expression in fat (RPKM 69.4), ovary (RPKM 49.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See BNIP3L in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (26383054..26413127)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26239894..26270644)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Balpha Neighboring gene SDA1 domain containing 1 pseudogene 1 Neighboring gene GATA motif-containing MPRA enhancer 260 Neighboring gene dnaJ homolog subfamily B member 6-like Neighboring gene uncharacterized LOC105379337

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Mitophagy - animal, organism-specific biosystem (from KEGG)
      Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Mitophagy - animal, conserved biosystem (from KEGG)
      Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Photodynamic therapy-induced HIF-1 survival signaling, organism-specific biosystem (from WikiPathways)
      Photodynamic therapy-induced HIF-1 survival signaling, organism-specific biosystemPhotodynamic therapy may induce a hypoxic survival response mediated by HIF-1.
    • TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystem (from REACTOME)
      TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystemThe tumor suppressor TP53 (p53) exerts its tumor suppressive role in part by regulating transcription of a number of genes involved in cell death, mainly apoptotic cell death. The majority of apoptot...
    • TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, organism-specific biosystem (from REACTOME)
      TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, organism-specific biosystemApoptotic transcriptional targets of TP53 include genes that regulate the permeability of the mitochondrial membrane and/or cytochrome C release, such as BAX, BID, PMAIP1 (NOXA), BBC3 (PUMA) and prob...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    lamin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to hypoxia IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane permeabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    regulation of autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
    Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
    BCL2/adenovirus E1B 19-kd protein-interacting protein 3a
    BCL2/adenovirus E1B 19kDa interacting protein 3 like
    NIP-3-like protein X
    NIP3-like protein X
    NIP3L
    adenovirus E1B19k-binding protein B5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330491.2NP_001317420.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011726, AK316315, BG942896
      Consensus CDS
      CCDS83267.1
      UniProtKB/Swiss-Prot
      O60238
      Related
      ENSP00000429851.1, ENST00000518611.5
      Conserved Domains (1) summary
      pfam06553
      Location:17178
      BNIP3; BNIP3
    2. NM_004331.3NP_004322.1  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1

      See identical proteins and their annotated locations for NP_004322.1

      Status: REVIEWED

      Source sequence(s)
      AA946755, AB004788, AF536326, AL132665, BF337139, BQ719112, CD244492, CD558918
      Consensus CDS
      CCDS6050.1
      UniProtKB/Swiss-Prot
      O60238
      UniProtKB/TrEMBL
      Q6IBV1
      Related
      ENSP00000370003.2, ENST00000380629.7
      Conserved Domains (1) summary
      pfam06553
      Location:28218
      BNIP3; BNIP3

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      26383054..26413127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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