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    Ctsc cathepsin C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25423, updated on 3-Apr-2018
    Official Symbol
    Ctscprovided by RGD
    Official Full Name
    cathepsin Cprovided by RGD
    Primary source
    RGD:2445
    See related
    Ensembl:ENSRNOG00000016496
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CATC; DPPI; DPP-I
    Summary
    acts as a cysteine dipeptidyl aminopeptidase; may play a role in immune and inflammatory response [RGD, Feb 2006]
    Expression
    Biased expression in Liver (RPKM 604.8), Kidney (RPKM 269.7) and 7 other tissues See more
    Orthologs
    Location:
    1q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (151918514..151949979)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (158231534..158263124)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 5 Neighboring gene eukaryotic translation initiation factor 5-like Neighboring gene uncharacterized LOC102554680 Neighboring gene RAB38, member RAS oncogene family Neighboring gene similar to Phosphoglycerate kinase 1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chloride ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidase activator activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein self-association IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteolysis involved in cellular protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis TAS
    Traceable Author Statement
    more info
    PubMed 
    proteolysis involved in cellular protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to organic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    dipeptidyl peptidase 1
    Names
    cathepsin J
    dipeptidyl peptidase I
    dipeptidyl transferase
    NP_058793.1
    XP_008757858.1
    XP_008757859.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017097.1NP_058793.1  dipeptidyl peptidase 1 precursor

      See identical proteins and their annotated locations for NP_058793.1

      Status: PROVISIONAL

      Source sequence(s)
      D90404
      UniProtKB/Swiss-Prot
      P80067
      Related
      ENSRNOP00000022342.3, ENSRNOT00000022342.5
      Conserved Domains (3) summary
      cd02621
      Location:230459
      Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...
      pfam04595
      Location:168204
      Pox_I6; Poxvirus I6-like family
      pfam08773
      Location:26138
      CathepsinC_exc; Cathepsin C exclusion domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      151918514..151949979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759636.2XP_008757858.1  dipeptidyl peptidase 1 isoform X1

      Conserved Domains (1) summary
      pfam08773
      Location:26106
      CathepsinC_exc; Cathepsin C exclusion domain
    2. XM_008759637.2XP_008757859.1  dipeptidyl peptidase 1 isoform X2

      See identical proteins and their annotated locations for XP_008757859.1

      Conserved Domains (1) summary
      pfam08773
      Location:26106
      CathepsinC_exc; Cathepsin C exclusion domain

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      140327884..140359275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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